Reduced Vascular Response to Angiotensin Ii in Secondary Hyperaldosteronism*

Johnston, Colin I.; Jose, Anthony D.

doi:10.1172/jci104826

Cited by 54 publications

(16 citation statements)

References 27 publications

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“…The mean overall blood flow response to A,, was 49 ml/min before and 40 ml/min after the cyclo-oxygenase inhibitor had been infused (difference NS, Table IIIB (2,(7)(8)(9). Decreases in the pressor response to All have also been documented in a variety of diseases in which the renin-angiotensin system is activated (7,9,(13)(14)(15)(16)(17).…”

Section: Resultsmentioning

confidence: 94%

“…The influenice of sodium balance on the vascular action of A11 has been studied primiarily by monitoring the blood pressuire rise produced by an intravenous infusion of the hormiione (6)(7)(8)(9)(13)(14)(15)(16)(17). This approach, however, is complicated by the fact that All, in addition to its direct actioni to produce vasoconstrictio(n of arteriolar smooth muscle, also influences blood pressure indirectly through actions on the central and sympathetic nervous systems (32,33), on the adrenal medulla (33), the heart (34), and possibly also on the systemic veins (4).…”

Section: Resultsmentioning

confidence: 99%

“…All to normal women receiving estrogein-containing oral contraceptives (52). Similarly, it may explain the blunted pressor sensitivity to All in a variety of diseases (7,9,(14)(15)(16)(17). For example, the blunted pressor response to A11 observed in patients with the syndrome ofjuxtaglomerular cell hyperplasia (Bartter's syndrome) is significantly enhanced when peripheral plasma renin activity is suppressed by saline infusion (53) or administration of propranolol or indomethacin (16).…”

Section: Resultsmentioning

confidence: 99%

“…Differences in the pressor responsiveness to Al have also been reported in a variety of diseases including cirrhosis with ascites (9,13,14), nephrosis (14), malignant and reniovascular hypertension (7), Bartter's syndrome (15,16), and Addison's disease (17). The mechanisms underlying these variations have not been clarified.…”

Section: Introductionmentioning

confidence: 99%

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The effect of altered sodium balance upon renal vascular reactivity to angiotensin II and norepinephrine in the dog. Mechanism of variation in angiotensin responses.

Oliver¹,

Cannon²

1978

J. Clin. Invest.

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A B S T R A C T The mechanism whereby the vasoconstrictor response to angiotensin II (A,,) is influenced by sodium balance or disease is unclear. To explore this question, the renal vascular responses (RVR) to intrarenal injections of subpressor doses of A,, and norepinephrine were studied in dogs with an electromagnetic flowmeter. Acute and chronic sodium depletion increased plasma renin activity (PRA) and blunted the RVR to A,,, while acute sodium repletion and chronic sodium excess plus desoxycorticosterone acetate decreased PRA and enhanced the RVR to All.The magnitude of the RVR to Al1 was inversely related to PRA. The RVR to norepinephrine was unaffected by sodium balance and was not related to PRA. Inhibition of the conversion of angiotensin I to Al, by SQ 20,881 during sodium depletion lowered mean arterial blood pressure (MABP), increased renal blood flow (RBF), and enhanced the RVR to Al, but not to norepinephrine. Administration of bradykinin to chronically sodium-depleted dogs also lowered the MABP and increased RBF but had no effect on the RVR to A11. SQ 20,881 had no effect on MABP, RBF, or the RVR to Al1 in the dogs with chronic sodiuni excess and desoxycorticosterone acetate. Administration of indomethacin to chronically sodium-depleted dogs lowered RBF but did not influence the RVR to A,,.The results indicate that the RVR to A,, is selectively influenced by sodium balance and that the magnitude of the response is inversely related to the availability of endogenous AII The data did not suggest that the variations in the RVR to A,, were because of direct effects of sodium on vascular contraction, changes in

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of altered sodium balance upon renal vascular reactivity to angiotensin II and norepinephrine in the dog. Mechanism of variation in angiotensin responses.

Oliver¹,

Cannon²

1978

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…However, tachyphylaxis expressed by a change in the pressor response (17) or the glomerular filtration rate and renal plasma flow (18) to angiotensin II in high doses has been reported. In secondary hyperaldosteronism, a tachyphylaxis to angiotensin II, even in small amounts, has been suggested to explain the reduced vascular sensitivity to injected angiotensin II (19). During renal ischemia the elaboration of angiotensin II in the ischemic kidney may induce a local vascular tachyphylaxis.…”

Section: Discussionmentioning

confidence: 99%