Reduced white matter connectivity associated with auditory verbal hallucinations in first-episode and chronic schizophrenia: A diffusion tensor imaging study

Gao, Jie; Zhu, Feng; Wang, Wei; Fan, Yijun; Ma, Qingyan; Ma, Xiancang; Yang, Jian

doi:10.1016/j.pscychresns.2018.01.002

Cited by 27 publications

(19 citation statements)

References 53 publications

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“…These results are in line with a number of studies reporting reduced FA in the corpus callosum of individuals with schizophrenia (Henze et al, 2012;Lener et al, 2015;Reis Marques et al, 2014;Whitford et al, 2010;Zhuo et al, 2016). Though most studies have focused on differences in the genu and splenium of the corpus callosum in those with schizophrenia compared with healthy controls (Zhuo et al, 2016), abnormalities in the callosal body have also been reported (Henze et al, 2012;Reis Marques et al, 2014;Zhang et al, 2018). Of greatest significance to the current study are findings by These authors also identified regions of lower FA in tracts such as the uncinate fasciculus and fornix (Reis Marques et al, 2014) that were not seen in the current study.…”

Section: Discussionsupporting

confidence: 88%

Differences in white matter connectivity between treatment-resistant and treatment-responsive subtypes of schizophrenia

McNabb

Kydd

Sundram

et al. 2018

Psychiatry Research: Neuroimaging

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Schizophrenia is a heterogeneous disorder exhibiting variable responsiveness to treatment between individuals. Previous work demonstrated that white matter abnormalities may relate to antipsychotic response but no study to date has examined differences between first-line treatment responders (FLR) and clozapine-eligible individuals receiving first-line antipsychotics. The current study aimed to establish whether differences in white matter structure exist between these two cohorts. Diffusionweighted images were acquired for 15 clozapine-eligible and 10 FLR participants. Measures of fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD) were obtained and between-group ttests interrogating differences in FA were conducted. To investigate the neural basis of a decrease in FA, the significant cluster from FA analysis was masked and used to obtain mean RD and AD measures for that region. Those who were clozapine-eligible had significantly lower FA in the body of the corpus callosum (p<0.05), associated with a significant increase in mean RD compared with FLR (p<0.001). No difference in mean AD was observed for this region. These data reveal differences in diffusion measures between FLR and those eligible for clozapine and suggest that lower FA and greater RD in the corpus callosum could exist as a biomarker of treatment resistance in people with schizophrenia.

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Section: Discussionsupporting

confidence: 88%

Differences in white matter connectivity between treatment-resistant and treatment-responsive subtypes of schizophrenia

McNabb

Kydd

Sundram

et al. 2018

Psychiatry Research: Neuroimaging

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“…Our findings indicate a crucial role for white matter deficits in AVH. Consistent with several previous studies (Hubl et al ., 2004; Xi et al ., 2016; Zhang et al ., 2018), white matter deficits affected the corpus collosum and internal capsule, confirming involvement of widely distributed commissural, frontal, reciprocal thalamo-cortical and auditory-linked circuitry in the generation of AVH. However, different white matter tracts have been implicated across prior reports, including the superior longitudinal fasciculus (Seok et al ., 2007; Ćurčić-Blake et al ., 2015), inferior longitudinal fasciculus (Seok et al ., 2007), inferior fronto-occipital fasciculus (Ćurčić-Blake et al ., 2015; Oestreich et al ., 2016), anterior thalamic radiation (Ćurčić-Blake et al ., 2015) and AF (the AF was not examined in the current study; Hubl et al ., 2004; Psomiades et al ., 2016).…”

Section: Discussionmentioning

confidence: 77%

“…Evidence for white matter pathology derives from diffusion MRI studies, reporting changes in diffusion tensor imaging (DTI) indices such as the fractional anisotropy (FA). However, little consensus exists regarding the location of abnormalities, with some studies reporting changes in circuits connecting speech areas (Seok et al ., 2007; Catani et al ., 2011; Kubicki et al ., 2011; Ćurčić-Blake et al ., 2015; Oestreich et al ., 2016; Psomiades et al ., 2016), and others in commissural fibers and subcortical–cortical connections (Hubl et al ., 2004; Mulert et al ., 2012; Xi et al ., 2016; Zhang et al ., 2018), which are outside language-linked circuitry. In addition, some studies report increased (Hubl et al ., 2004; Mulert et al ., 2012), and others, decreased FA (Seok et al ., 2007; Ćurčić-Blake et al ., 2015; Oestreich et al ., 2016) in schizophrenia patients with AVH.…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging auditory verbal hallucinations in schizophrenia patient and healthy populations

et al. 2019

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BackgroundAuditory verbal hallucinations (AVH) are a cardinal feature of schizophrenia, but they can also appear in otherwise healthy individuals. Imaging studies implicate language networks in the generation of AVH; however, it remains unclear if alterations reflect biologic substrates of AVH, irrespective of diagnostic status, age, or illness-related factors. We applied multimodal imaging to identify AVH-specific pathology, evidenced by overlapping gray or white matter deficits between schizophrenia patients and healthy voice-hearers.MethodsDiffusion-weighted and T1-weighted magnetic resonance images were acquired in 35 schizophrenia patients with AVH (SCZ-AVH), 32 healthy voice-hearers (H-AVH), and 40 age- and sex-matched controls without AVH. White matter fractional anisotropy (FA) and gray matter thickness (GMT) were computed for each region comprising ICBM-DTI and Desikan–Killiany atlases, respectively. Regions were tested for significant alterations affecting both SCZ-AVH and H-AVH groups, relative to controls.ResultsCompared with controls, the SCZ-AVH showed widespread FA and GMT reductions; but no significant differences emerged between H-AVH and control groups. While no overlapping pathology appeared in the overall study groups, younger (<40 years) H-AVH and SCZ-AVH subjects displayed overlapping FA deficits across four regions (p < 0.05): the genu and splenium of the corpus callosum, as well as the anterior limbs of the internal capsule. Analyzing these regions with free-water imaging ascribed overlapping FA abnormalities to tissue-specific anisotropy changes.ConclusionsWe identified white matter pathology associated with the presence of AVH, independent of diagnostic status. However, commonalities were constrained to younger and more homogenous groups, after reducing pathologic variance associated with advancing age and chronicity effects.

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“…These findings would indicate that dysregulated BDNF levels in schizophrenia patients might point to impaired repair mechanisms with elevated serum concentrations as a response to altered structural connectivity, rather than an early step in the causal chain that leads to these alterations in connectivity. In addition, the SLF has been repeatedly indicated as altered in schizophrenia patients by various studies (63,82); Studies found that FA values were decreased in the SLF (83)(84)(85) in patient populations. This was interpreted by the authors as a potential mesostructural correlation of altered neural plasticity.…”

Section: A Potential Role For Bdnf In Fiber Tract Changes Of Schizophmentioning

confidence: 99%

BDNF Serum Levels are Associated With White Matter Microstructure in Schizophrenia - A Pilot Study

et al. 2020

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Reduced white matter connectivity associated with auditory verbal hallucinations in first-episode and chronic schizophrenia: A diffusion tensor imaging study

Cited by 27 publications

References 53 publications

Differences in white matter connectivity between treatment-resistant and treatment-responsive subtypes of schizophrenia

Differences in white matter connectivity between treatment-resistant and treatment-responsive subtypes of schizophrenia

Neuroimaging auditory verbal hallucinations in schizophrenia patient and healthy populations

BDNF Serum Levels are Associated With White Matter Microstructure in Schizophrenia - A Pilot Study

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