Reducing bacterial resistance to antibiotics with ultrasound

Rediske, Andrea M.; Rapoport, Natalya; Pitt, William G.

doi:10.1046/j.1365-2672.1999.00461.x

Cited by 44 publications

(33 citation statements)

References 13 publications

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“…This would seemingly follow previous theories surrounding a charged EPS matrix [23,35] by suggesting that structural changes to the biofilm enhancing its susceptibility to antimicrobials are related to both mechanical and electrical characteristics. The way in which an electromagnetic field acts upon the polar parts of the EPS matrix via vibration energy was suggested to be comparable to other research efforts using ultrasonic frequencies to kill biofilms [78][79][80]. Caubet admits that at the time of reporting, attempts to model both the mechanical structure of and electric fields within biofilms were insufficiently well developed to yield any quantitative results from experimental data [29].…”

Section: The Bioelectric Effectmentioning

confidence: 79%

Electrical methods of controlling bacterial adhesion and biofilm on device surfaces

Freebairn

Linton

Harkin‐Jones

et al. 2013

Expert Review of Medical Devices

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SummaryThis review will summarize the significant body of research within the field of electrical methods of controlling the growth of microorganisms. We examine the progress from early work using current to kill bacteria in static fluids to more realistic treatment scenarios such as flow-through systems designed to imitate the human urinary tract. Additionally, the electrical enhancement of biocide and antibiotic efficacy will be examined alongside recent innovations including the biological applications of acoustic energy systems to prevent bacterial surface adherence. Particular attention will be paid to the electrical engineering aspects of previous work, such as electrode composition, quantitative electrical parameters, and the conductive medium used. Scrutiny of published systems from an electrical engineering perspective will help to facilitate improved understanding of the methods, devices and mechanisms that have been effective in controlling bacteria, as well as providing insights and strategies to improve the performance of such systems and develop the next generation of antimicrobial bioelectric materials.

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Section: The Bioelectric Effectmentioning

confidence: 79%

Electrical methods of controlling bacterial adhesion and biofilm on device surfaces

Freebairn

Linton

Harkin‐Jones

et al. 2013

Expert Review of Medical Devices

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“…Chemotherapy-Rediske et al showed that ultrasound increased the killing of bacteria both in planktonic suspension [196,197] and biofilm forms [198][199][200] in the presence of antibiotics. This synergistic killing effect was most pronounced at lower frequencies and decreased as the frequency of insonation increased [201,202].…”

Section: Antibacterialmentioning

confidence: 99%

Ultrasonic drug delivery – a general review

Pitt

Husseini

Staples

2004

Expert Opinion on Drug Delivery

557

428

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Ultrasound (US) has an ever-increasing role in the delivery of therapeutic agents including genetic material, proteins, and chemotherapeutic agents. Cavitating gas bodies such as microbubbles are the mediators through which the energy of relatively non-interactive pressure waves is concentrated to produce forces that permeabilize cell membranes and disrupt the vesicles that carry drugs. Thus the presence of microbubbles enormously enhances delivery of genetic material, proteins and smaller chemical agents. Delivery of genetic material is greatly enhanced by ultrasound in the presence of microbubbles. Attaching the DNA directly to the microbubbles or to gas-containing liposomes enhances gene uptake even further. US-enhanced gene delivery has been studied in various tissues including cardiac, vascular, skeletal muscle, tumor and even fetal tissue. US-enhanced delivery of proteins has found most application in transdermal delivery of insulin. Cavitation events reversibly disrupt the structure of the stratus corneum to allow transport of these large molecules. Other hormones and small proteins could also be delivered transdermally. Small chemotherapeutic molecules are delivered in research settings from micelles and liposomes exposed to ultrasound. Cavitation appears to play two roles: it disrupts the structure of the carrier vesicle and releases the drug; it also makes the cell membranes and capillaries more permeable to drugs. There remains a need to better understand the physics of cavitation of microbubbles and the impact that such cavitation has upon cells and drug-carrying vesicles.

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“…Our previous research showed that ultrasound enhanced the activity of aminoglycosides against Gram-negative bacteria in both planktonic and biofilm phenotypes (6,(13)(14)(15)(16)(17)(18). Ultrasound also increased killing of Gram-positive S. epidermidis and Streptococcus mitis by ampicillin (16).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonically Enhanced Vancomycin Activity Against Staphylococcus Epidermidis Biofilms in Vivo

et al. 2004

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SUMMARYInfection of implanted medical devices by Gram-positive organisms such as Staphylococcus ssp. is a serious concern in the biomaterial community. In this research the application of low frequency ultrasound to enhance the activity of vancomycin against implanted Staphylococcus epidermidis biofilms was examined. Polyethylene disks covered with a biofilm of S. epidermidis were implanted subcutaneously in rabbits on both sides of their spine. The rabbits received systemic vancomycin for the duration of the experiment. Following 24 h of recovery, one disk was insonated for 24 or 48 h while the other was a control. Disks were removed and viable bacteria counted. At 24 h of insonation, there was no difference in viable counts between control and insonated biofilms, while at 48 h of insonation there were statistically fewer viable bacteria in the insonated biofilm. The S. epidermidis biofilms responded favorably to combinations of ultrasound and vancomycin, but longer treatment times are required for this Gram-positive organism than was observed previously for a Gram-negative species.

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Reducing bacterial resistance to antibiotics with ultrasound

Cited by 44 publications

References 13 publications

Electrical methods of controlling bacterial adhesion and biofilm on device surfaces

Electrical methods of controlling bacterial adhesion and biofilm on device surfaces

Ultrasonic drug delivery – a general review

Ultrasonically Enhanced Vancomycin Activity Against Staphylococcus Epidermidis Biofilms in Vivo

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