PURPOSE Socioeconomic status (SES) predicts coronary heart disease independently of the Framingham risk-scoring factors included in cholesterol treatment guidelines, possibly resulting in undertreatment of lower SES persons. We examined whether hybrid SES measures (based on area measures of income and individual education) address this bias and derived an approach to incorporating SES information into treatment guidelines.
METHODSThe Atherosclerosis Risk in Communities study data (initiated in 1987 with a 10-year follow-up of 15,495 adults aged 45 to 64 years in 4 southern and midwestern communities) were used to assess the calibration bias of 4 Cox models predicting 10-year coronary heart disease risk: Framingham risk score alone, and Framingham risk score plus SES using an individual-based measure (income less than 150% federal poverty level or less then 12 years of schooling), and 2 hybrid SES measures substituting area-based income measures (block group or zip code median incomes of less than 25th national percentiles) for the individual income component. Revised cholesterol treatment thresholds based on SES risk were also derived.
RESULTSUse of either the block group hybrid or individual-based SES measures eliminated the signifi cant SES bias observed using Framingham risk score alone. Cholesterol treatment guideline thresholds of 10% and 20% coronary heart disease risk (based on the Framingham risk score) were reduced to 6% and 13% for those with low SES.CONCLUSIONS Using patient income based on block group and individual education minimizes the SES bias in Framingham risk scoring and suggests more aggressive cholesterol treatment thresholds for low-SES persons. Ann Fam Med 2010;8:447-453. doi:10.1370/afm.1167.
INTRODUCTIONF ramingham risk scoring underestimates coronary heart disease risk for persons of lower socioeconomic status (SES), because SES is an independent risk factor not included in Framingham risk scoring. 1,2 Consequent inappropriately high treatment thresholds for low-SES persons may contribute to worsening SES disparities in coronary heart disease. 3 We have previously found that incorporating an individual-based SES measure (using individual patient education and household income) into coronary heart disease risk assessment mitigates underestimation of coronary heart disease risk among low SES persons determined by the Framingham risk score alone.2 That approach, however, required knowledge of patients' household income and family size, and their conversion into a percentage of the federal poverty level. Clinicians may be reluctant to ask patients about income; patients may be reluctant to disclose the information. In addition, no approach to incorporating SES risk into risk-based cholesterol treatment decision making was provided. Here we explore alternative approaches to assessing SES risk (using the patient's place of residence) and derive an approach to incorporating SES risk into treatment guidelines.
SES A ND CORONA RY HE A R T DISE A SE R ISKArea-based SES measures (using t...