This study examines the complex interplay between food security, climate change, population, water, and renewable energy desalination in five Arab countries: Morocco, Egypt, Jordan, Saudi Arabia, and the United Arab Emirates. Using a comprehensive econometric approach: an Auto-Regressive Distributed Lag approach (ARDL) and Vector Error Correction Model (VECM) technique spanning 1990–2022, to explore the short- and long-run dynamics of these relationships and identify causal linkages. The ARDL results reveal a mixed outcome. While renewable energy desalination capacity holds potential for enhancing food security in all countries, its impact depends on cost and government support. The cost of desalination negatively affects food security in most cases, highlighting the need for cost-effective solutions. Climate change poses a significant threat, particularly in Morocco, Egypt, and Jordan, but it may also offer unexpected opportunities for KSA and UAE. Population growth, unsurprisingly, strains food security across the region. Water scarcity emerges as a major challenge, especially for Jordan. The Granger causality tests uncover bidirectional relationships between renewable energy desalination, climate change, and water in Morocco and Jordan, suggesting their interconnected influence. In Egypt, population, water, and food imports drive the system, while KSA and UAE exhibit complex dynamics with renewable energy desalination and food imports acting as key drivers. Policymakers facing the complex challenge of food security in Arab countries should take note of this research’s multifaceted findings. While renewable energy desalination holds promise, its success hinges on reducing costs through technological advancements and government support, particularly in Morocco, Egypt, and Jordan. Climate change adaptation strategies must be prioritized, while recognizing potentially unexpected opportunities in regions like KSA and UAE. Additionally, addressing water scarcity through innovative resource management is crucial, especially for Jordan. Managing population growth through family planning initiatives and promoting sustainable agricultural practices are vital for long-term food security. Finally, the identified causal relationships underscore the need for integrated policy approaches that acknowledge the interconnectedness of these factors. By tailoring responses to the specific dynamics of each nation, policymakers can ensure effective interventions and secure a sustainable food future for the region.