“…Deep Mitosis (DM) technique, which consists of segmentation task, detection task, and classification task [21], always fails to differentiate between mitosis and nonmitosis cell shape. Recently, the object detection and instance segmentation framework Feature Pyramid Network (FPN) have been used to tackle different kinds of medical problems, such as detecting the porosity and cracks in concrete CT images [26], automatic segmentation of cervical nuclei [27], thyroid nodule detection from medical ultrasound images [28], detection of teeth and their components in X-ray images [29], lung nodule detection in chest X-rays images [30], and having attained outstanding results. e focal loss (FL) has been used to solve the data imbalance problem in the various kinds of biomedical datasets and performed well for minority class, such as classification of red blood cells morphology [31], colon gland instance segmentation [32], and localization of cell organelles [33].…”