Reducing multiple pregnancy from assisted reproduction treatment: educating patients and medical staff

Wang, Jim; Lane, Michelle; Norman, Robert J.

doi:10.5694/j.1326-5377.2006.tb00181.x

Cited by 15 publications

(8 citation statements)

References 17 publications

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“…There has been a decrease in the number of embryos transferred over the past decade, to reduce the complications associated with multiple births . This is reflected in our data, as the multiple birth rate decreased from 24.7% to 7.5%.…”

Section: Discussionmentioning

confidence: 59%

“…It allows for incomplete follow‐up and predicts what the outcome would be when a couple undertake a certain number of treatment cycles. Over the past decade, there has been a movement towards single embryo transfers to reduce the risk of multiple births and its associated complications . There is a misbelief among couples that the chance of pregnancy is reduced with single embryo transfers, which has been perpetuated by some studies that included outcomes from fresh embryo transfer cycles only .…”

Section: Introductionmentioning

confidence: 99%

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The success rate of IVF has significantly improved over the last decade

Wade

MacLachlan

Kovàcs

2015

Aust NZ J Obst Gynaeco

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

The success rate of IVF has significantly improved over the last decade

Wade

MacLachlan

Kovàcs

2015

Aust NZ J Obst Gynaeco

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“…Our analysis showed that the multiple birth rate for babies conceived by DET was nearly 10‐fold higher than for babies conceived by SET. Multiple births are strongly associated with poorer perinatal outcomes 4 , 12 . LBW and preterm birth have been shown to be directly related to fetal and neonatal death, and short‐ and long‐term morbidity and mortality 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

“…Studies suggest that the high incidence of multiple births following ART is responsible for most adverse perinatal outcomes (preterm birth, low birthweight [LBW] and perinatal death) 2 . ‐ 4 …”

mentioning

confidence: 99%

Perinatal outcomes after assisted reproductive technology treatment in Australia and New Zealand: single versus double embryo transfer

Wang

Sullivan

Healy

et al. 2009

Medical Journal of Australia

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Objective: To compare the perinatal outcomes of babies conceived by single embryo transfer (SET) with those conceived by double embryo transfer (DET). Design, setting and participants: A retrospective population‐based study of embryo transfer cycles in Australia and New Zealand between 2002 and 2006, using data from the Australia and New Zealand Assisted Reproduction Database. Main outcome measures: Proportion of SET procedures; comparison of SET and DET procedures with respect to multiple births, low birthweight (LBW), preterm birth and fetal death. Results: The proportion of SET procedures has increased from 28.4% in 2002 to 32.0% in 2003, 40.5% in 2004, 48.2% in 2005 and 56.9% in 2006. The multiple birth rate for all babies conceived by SET (4.0%) was 10 times lower than for those conceived by DET (39.1%) (P < 0.01). The average birthweight for all liveborn babies conceived by SET (3290 g) was higher than for those conceived by DET (2934 g) (P < 0.01). The preterm birth rate of all DET‐conceived babies (30.3%) was higher than for SET‐conceived babies (12.3%) (adjusted odds ratio [AOR], 3.19 [95% CI, 3.01–3.38]). All babies conceived by DET were more likely to be stillborn than those conceived by SET (AOR, 1.49 [95% CI, 1.21–1.82]). Singletons conceived by DET were more likely to be born preterm than singletons conceived by SET (AOR, 1.13 [95% CI, 1.05–1.22]). Liveborn singletons conceived by DET were 15% more likely to have LBW than liveborn singletons conceived by SET (AOR, 1.15 [95% CI, 1.05–1.26]). There was no significant difference in fetal death rate between DET‐ and SET‐conceived singletons. Conclusion: The increase in proportion of SET procedures has resulted in a lower rate of multiple births and in better perinatal outcomes in Australian and New Zealand assisted reproduction programs.

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“…By increasing the multiple pregnancy rate, the increasing use of artificial reproductive technology has a significant impact on the obstetric and neonatal services, especially on the economy of a small island. These demands are greater with higher‐order births and it is recommended that no more than two fertilized ova should be inserted each cycle [2].…”

Section: Maternal Morbidity Parametersmentioning

confidence: 99%