2016
DOI: 10.18632/oncotarget.14035
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Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue

Abstract: Sirtuin 1 (Sirt1) promotes adaptive thermogenesis by controlling the acetylation status of enzymes and transcriptional factors in interscapular brown adipose tissue (iBAT). However, the effects of Sirt1 on endoplasmic reticulum (ER) stress and apoptosis of iBAT remain elusive. In this study, the mRNA levels of Sirt1 and thermogenesis genes were reduced but the genes related with ER stress were elevated in iBAT of high-fat diet (HFD)-induced obese mice. Moreover, ER stress further inhibited mRNA level of Sirt1 … Show more

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Cited by 51 publications
(57 citation statements)
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“…The expression of genes was analysed by the method of 2 −ΔΔCt . Quantitative PCR was performed as previously described …”
Section: Methodsmentioning
confidence: 99%
“…The expression of genes was analysed by the method of 2 −ΔΔCt . Quantitative PCR was performed as previously described …”
Section: Methodsmentioning
confidence: 99%
“…The adipocyte culture was performed as previously described [18, 19]. Cells were differentiated after induction for 4 days.…”
Section: Methodsmentioning
confidence: 99%
“…Its possible mechanism was regulating the transcription of nuclear factor, and suppressing the transcription of TGF-b downstream Smad2 and Smad3. These genes regulated many cell signals related to proliferation and differentiation; for example, Smad3 promoted apoptosis by promoting the process of P21 and P15 inhibiting cell proliferation [18][19][20]. Therefore, c-Ski may participate in cell proliferation through the abovementioned pathways, affecting cell viability.…”
Section: Discussionmentioning
confidence: 99%