2021
DOI: 10.1002/hep.31583
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Reducing the Global Burden of Alcohol‐Associated Liver Disease: A Blueprint for Action

Abstract: Alcohol-associated liver disease (ALD) is a major driver of global liver related morbidity and mortality. There are 2.4 billion drinkers (950 million heavy drinkers) and the lifetime prevalence of any alcohol use disorder (AUD) is 5.1%-8.6%. In 2017, global prevalence of alcohol-associated compensated and decompensated cirrhosis was 23.6 million and 2.5 million, respectively. Combined, alcohol-associated cirrhosis and liver cancer account for 1% of all deaths worldwide with this burden expected to increase. So… Show more

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Cited by 106 publications
(92 citation statements)
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“…Beyond awareness and education about comorbid CLD-SUD, gastroenterologists and hepatologists serving this complex population need healthcare delivery systems in place to support truly integrated care. These systems can provide early identification of comorbid CLD-SUD through screening and then extend the treatment of CLD to include comorbid SUD when present through integrated care delivery models ( 5 , 38 , 50 , 51 ).…”
Section: Discussionmentioning
confidence: 99%
“…Beyond awareness and education about comorbid CLD-SUD, gastroenterologists and hepatologists serving this complex population need healthcare delivery systems in place to support truly integrated care. These systems can provide early identification of comorbid CLD-SUD through screening and then extend the treatment of CLD to include comorbid SUD when present through integrated care delivery models ( 5 , 38 , 50 , 51 ).…”
Section: Discussionmentioning
confidence: 99%
“…However, there are not always satisfactory for HCC targeted therapies in partial patients due to the differences of their clinicopathological features and genes (20). For example, it is well known that alcohol consumption is a risk factor for HCC and other cancers (21)(22)(23)(24)(25), but there are still many unknown molecular mechanisms and prognostic biomarkers in alcoholrelated HCC. Therefore, prognostic biomarkers with higher prediction accuracy in predicting prognosis are urgently needed before detectable clinicopathological abnormalities in treatments of alcohol-related HCC patients.…”
Section: Discussionmentioning
confidence: 99%
“…[18] Several factors including gender, alcohol use patterns (binge use, drinking outside meals, type of alcohol, and severity of AUD), socioeconomic status, having insurance, receipt of treatment for risk factor of AUD, and specialty care for liver disease determine receipt of treatment of any liver disease including ALD. [19,20] Further, genetic polymorphisms of alcohol metabolizing enzymes may predispose an individual to AUD, and polymorphisms of PNPLA3, TMSF62, and MBOAT7 genes have been shown to predispose an individual with AUD to development of and severity of ALD. [21] Although, we were able to account for socioeconomic and insurance status, lack of availability of data on other clinical variables in the NIS database and blood samples for genetic analyses limited assessment on association of other variables with predisposition of AUD and ALD in AI/AN individuals.…”
Section: Discussionmentioning
confidence: 99%
“…Large multicenter studies are needed to examine other factors such as alcohol use patterns, receipt and type of provider care for AUD and for liver disease, genetic polymorphisms to further study mechanisms of our ndings. Further, these studies would also provide useful data to derive public health policies like prevention or treatment of AUD, early detection of silent advanced brosis, and increased access to healthcare, and reduce ALD related healthcare burden, [20] especially in AI/AN.…”
Section: Discussionmentioning
confidence: 99%