Reducing the rehospitalization risk after a manic episode: A population based cohort study of lithium, valproate, olanzapine, quetiapine and aripiprazole in monotherapy and combinations

Abstract

One-year rehospitalization rates after a manic episode are considerable also for patients who initiate prophylactic treatment. Combination therapies including olanzapine and a classic mood-stabilizer may be beneficial for reducing rehospitalization risks after a manic episode.

Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: a systematic review of evidence from observational studies

“…As can be seen from Table , the nine studies consisted of four nationwide register‐based studies from Sweden, the UK and Denmark (two studies), among which three included nationwide data and one used the US National MarketScan research database, three prospective follow‐up studies from Austria, Germany, and Italy, and one retrospective chart review study from Canada . The studies included data from a total of 14 271 patients with bipolar disorder.…”

Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: A randomized controlled trial

“…We focused our study on individuals recently discharged following hospitalization for acute mania, since we and others had previously identified these individuals at a high risk for relapse as evidenced by rehospitalization. Even when compliance and the use of evidence‐based treatments are assured, the risk of symptom exacerbations leading to rehospitalization remains relatively high . Recurrent mood episodes contribute to patients' social disability and reduce their quality of life .…”

“…Even when compliance and the use of evidence-based treatments are assured, the risk of symptom exacerbations leading to rehospitalization remains relatively high. 2,3 Recurrent mood episodes contribute to patients' social disability and reduce their quality of life. 40 Hospital readmissions in particular are disruptive to patients' lives and contribute to increased health care costs for patients and health care insurers.…”

“…Individuals who are hospitalized for mania are at high risk for the recurrence of mood episodes and for psychiatric rehospitalization in the months after hospital discharge . Data from recent observational studies indicate that rehospitalization is common in this population even when evidence‐based treatments are used …”

“…1,2 Data from recent observational studies indicate that rehospitalization is common in this population even when evidence-based treatments are used. 2,3 Immunological abnormalities have been identified in individuals with mania and may contribute to the pathophysiology of this acute mood state as well as to bipolar disorder more broadly. [4][5][6][7] In a previous study performed by our group, individuals hospitalized for mania with increased levels of inflammation were more likely to be rehospitalized in the 6 months following discharge.…”