Reducing the risk of chronic heart failure development in patients with arterial hypertension from the position of evidence medicine (focus on candesartan)

Abstract

Arterial hypertension is the main risk factor for the development of cardiovascular complications and makes a significant contribution to cardiovascular morbidity, including chronic heart failure, and mortality, amounting to more than 45%. The leading risk factors for the development of cardiovascular diseases also include a violation of lipid and carbohydrate metabolism. Current treatments for cardiovascular disease include the administration of angiotensin II receptor blockers. This article provides an overview of the literature data on the efficacy, safety profile of candesartan, high adherence to this drug in patients with arterial hypertension, chronic heart failure, impaired carbohydrate and lipid metabolism. The advantages of candesartan in comparison with other representatives of this group of drugs in the prevention of chronic heart failure are emphasized according to large-scale international randomized trials. Keywords: arterial hypertension, atherosclerosis, diabetes mellitus, insulin resistance, chronic heart failure, candesartan, Hyposart For citation: Evdokimova AG, Stryuk RI, Evdokimov VV, Golikova AA. Reducing the risk of chronic heart failure development in patients with arterial hypertension from the position of evidence medicine (focus on candesartan). Consilium Medicum. 2021; 23 (1): 84–92. DOI: 10.26442/20751753.2021.1.200730