The paper develops an important method related to using algebraic inequalities for uncertainty and risk reduction and enhancing systems performance. The method consists of creating relevant meaning for the variables and different parts of the inequalities and linking them with real physical systems or processes. The paper shows that inequalities based on multivariable sub-additive functions can be interpreted meaningfully and the generated new knowledge used for optimising systems and processes in diverse areas of science and technology. In this respect, an interpretation of the Bergström inequality, which is based on a sub-additive function, has been used to increase the accumulated strain energy in components loaded in tension and bending. The paper also presents an interpretation of the Chebyshev’s sum inequality that can be used to avoid the risk of overestimation of returns from investments and an interpretation of a new algebraic inequality that can be used to construct the most reliable series-parallel system. The meaningful interpretation of other algebraic inequalities yielded a highly counter-intuitive result related to assigning devices of different types to missions composed of identical tasks. In the case where the probabilities of a successful accomplishment of a task, characterising the devices, are unknown, the best strategy for a successful accomplishment of the mission consists of selecting randomly an arrangement including devices of the same type. This strategy is always correct, irrespective of existing uknown interdependencies among the probabilities of successful accomplishment of the tasks characterising the devices.