Reducing urinary oxalate by simultaneous using Sankol herbal drop with oxalate-degrading bacteria

Abstract

Background and Objectives: Oxalate degrading bacteria and herbal extracts are new strategy for reducing hyperoxaluria. In Iranian traditional medicine, Sankol oral drop is widely used as an antispasmodic drug to reduce stones from urinary tract. This study aimed to evaluate the synergistic effect of oxalate-degrading bacteria and Sankol oral drop in reducing urinary oxalate in rat model.
 Materials and Methods: Several bacterial strains, including Lactobacillus (4), Bifidobacterium (2) and L. paracasei (2) (very strong in degrading oxalate in vitro) were used in this study. Male Wistar rats were divided into 6 groups (n = 6). The rats of Group I received normal diet and drinking water + 60% ethanol (positive group). Groups II (negative group), III, IV, V, and VI rats received diet containing ethylene glycol (3%) for 30 days. Groups III rats received Sankol with minimum concentration (7.5 ml/kg/b.w), Group IV rats received Sankol with maximum concentration (9 ml/kg/b.w), Group V rats received Sankol with minimum concentration + probiotic, and Group VI rats received Sankol with maximum concentration
 + probiotic for 30 days.
 Results: Treatment with Sankol (maximum concentration) and oxalate-degrading probiotic bacteria significantly reduced urinary oxalate (P = .0001). At the end of treatment period, rats in groups II (negative control) showed a high score of CaOx crystal, while rats in VI groups did not show any CaOx crystal.
 Conclusion: This is the first study on the simultaneous use of Sankol herbal drop and oxalate-degrading probiotic bacteria that showed a significant reduction in urinary oxalate.

Therapeutic effects of probiotics and herbal medications on oxalate nephrolithiasis: a mini systematic review

“…Consumption of plant extracts (without probiotic) for 30 days decreased renal inflammation and urinary parameters. The simultaneous administration of herbal compounds with probiotics able to reduce the inflammation and renal calcium oxalate deposition in shorter periods (20 days) is associated with immunosuppressive and inflammatory potential of L. plantarum and L. paracasei as strains with high power in oxalate degradation ( 50 ). In line with this study, Afkari et al (2019) used the same probiotic strains plus Sankol oral drops (7.5–9 ml/kg/body weight) in rat model.…”

Probiotics: truths and illusions

“…In another study, the adjuvant therapy potential of compounds derived from probiotics called postbiotics in colorectal cancer has been investigated ( 17 ). Also, some probiotic strains have been suggested as preventive factors and adjuvant therapy for kidney stones and nephrolithiasis ( 18 ).…”