Reduction and sensitization of CRH neuron in rat hypothalamic and extrahypothalamic regions after chronic variable stress

CGRP antagonist infused into the bed nucleus of the stria terminalis impairs the acquisition and expression of context but not discretely cued fear

“…Many of these systems are responsive to stress (c.f., Hokfelt 1991;Hokfelt et al 2000) and, as such, are potential therapeutic targets for stress-related pathologies. A large body of evidence has pointed to corticotropinreleasing factor (CRF) as one such peptide (Chappell et al 1986;Lee and Davis 1997;Nagashima et al 2003;Cooper and Huhman 2005;Hishinuma et al 2005;Choi et al 2006;Sahuque et al 2006;Santibanez et al 2006;Lee et al 2008;Shepard et al 2009;Sterrenburg et al 2011;Lebow et al 2012), and more recent data have suggested an important role for pituitary adenylate cyclase-activating peptide (PACAP) as well (Hammack et al 2009(Hammack et al , 2010; for possible clinical relevance also see Ressler et al 2011;Almli et al 2013;Jovanovic et al 2013).…”