Reduction by propranolol of urinary hydroxyproline excretion in human hyperthyroidism: A beta-receptor blockade effect or a membrane stabilizing mechanism?

Beylot, M.; Borson, F.; David, L; Sautot, G; Riou, Jean‐Paul; Mornex, R

doi:10.1016/0026-0495(84)90123-9

Cited by 8 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Considering the negative effects of thyrotoxicosis and SNS activation on bone mass, we raised the hypothesis that TH may also interact with the SNS to regulate bone metabolism. A piece of evidence supporting this possible interaction is the fact that the treatment of hyperthyroid patients with propranolol corrects their hypercalcemia (53) and decreases their urinary excretion of hydroxyproline, a biochemical marker of bone resorption (6).…”

mentioning

confidence: 99%

Thyroid hormone interacts with the sympathetic nervous system to modulate bone mass and structure in young adult mice

Fonseca

Teixeira

Rodrigues-Miranda

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

To investigate whether thyroid hormone (TH) interacts with the sympathetic nervous system (SNS) to modulate bone mass and structure, we studied the effects of daily T3 treatment in a supraphysiological dose for 12 wk on the bone of young adult mice with chronic sympathetic hyperactivity owing to double-gene disruption of adrenoceptors that negatively regulate norepinephrine release, α(2A)-AR, and α(2C)-AR (α(2A/2C)-AR(-/-) mice). As expected, T3 treatment caused a generalized decrease in the areal bone mineral density (aBMD) of WT mice (determined by DEXA), followed by deleterious effects on the trabecular and cortical bone microstructural parameters (determined by μCT) of the femur and vertebra and on the biomechanical properties (maximum load, ultimate load, and stiffness) of the femur. Surprisingly, α(2A/2C)-AR(-/-) mice were resistant to most of these T3-induced negative effects. Interestingly, the mRNA expression of osteoprotegerin, a protein that limits osteoclast activity, was upregulated and downregulated by T3 in the bone of α(2A/2C)-AR(-/-) and WT mice, respectively. β1-AR mRNA expression and IGF-I serum levels, which exert bone anabolic effects, were increased by T3 treatment only in α(2A/2C)-AR(-/-) mice. As expected, T3 inhibited the cell growth of calvaria-derived osteoblasts isolated from WT mice, but this effect was abolished or reverted in cells isolated from KO mice. Collectively, these findings support the hypothesis of a TH-SNS interaction to control bone mass and structure of young adult mice and suggests that this interaction may involve α2-AR signaling. Finally, the present findings offer new insights into the mechanisms through which TH regulates bone mass, structure, and physiology.

show abstract

mentioning

confidence: 99%

Thyroid hormone interacts with the sympathetic nervous system to modulate bone mass and structure in young adult mice

Fonseca

Teixeira

Rodrigues-Miranda

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…Increased levels of blood glycerol and ketone bodies and increased urinary hydroxyproline excretion in hyperthyroid patients are reduced by pro¬ pranolol but not by timolol (which has no effect on plasma T3). (43,44) Propranolol decreased oxygen consumption in rela¬ tion to the decrease of plasma T3 in one study'45' but not in another.146' The fall in oxygen consumption, if any, appears to be unrelated to a diminished plasma T3, since atenolol also decreased oxygen consumption in the absence of T3 changes/25' Neither propranolol nor metoprolol modified the increased protein synthesis and degradation in hyperthyroidism. '47·48' Taken together, these studies indicate no metabolic improve¬ ment or only modest benefit due to ß-blockade in thyrotoxicosis.…”

Section: Clinical Response In Hyperthyroidismmentioning

confidence: 99%

Propranolol and Thyroid Hormone Metabolism

Wiersinga

1991

Thyroid

View full text Add to dashboard Cite

Propranolol decreases plasma T3 and increases plasma rT3 in a dose-dependent manner due to a decreased production rate of T3 and a decreased metabolic clearance rate of rT3, respectively, caused by inhibition of the conversion of T4 into T3 and of rT3 into 3,3'-T2. This inhibition of 5'-deiodination is not secondary to inhibition of thyroid hormone transport across the plasma membrane. Propranolol and its major metabolite, 4-hydroxypropranolol, are not directly responsible for these effects, but an unidentified metabolite of propranolol might be involved. beta-blockers ameliorate clinical symptoms and signs of thyrotoxicosis independent of the decrease of plasma 13, that is confined to beta-blockers with membrane-stabilizing activity, such as propranolol and alprenolol. The decrease of plasma T3, however, appears responsible for some of the metabolic responses to beta-blockers.

show abstract

“…One evidence of this possible interaction is the fact that treatment of hyperthyroid patients with propanolol (a β-adrenergic antagonist) corrects the thyrotoxicosis-induced hypercalcemia (76). Furthermore, patients with hypothyroidism treated with propanolol showed a decrease in the urinary excretion of hydroxyproline, a biochemical marker for bone resorption (77).…”

Section: Evidence That Thyroid Hormone Interacts With the Sns Via α mentioning

confidence: 99%

Estudo da interação do Hormônio Tireoideano com o sistema α2 adrenérgico no crescimento ósseo endocondral: uma avaliação em cultura de órgão. [Tese (Doutorado em Ciências Morfofuncionais) ]. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo; 2017.

Rodrigues¹

View full text Add to dashboard Cite

show abstract

Reduction by propranolol of urinary hydroxyproline excretion in human hyperthyroidism: A beta-receptor blockade effect or a membrane stabilizing mechanism?

Cited by 8 publications

References 15 publications

Thyroid hormone interacts with the sympathetic nervous system to modulate bone mass and structure in young adult mice

Thyroid hormone interacts with the sympathetic nervous system to modulate bone mass and structure in young adult mice

Propranolol and Thyroid Hormone Metabolism

Estudo da interação do Hormônio Tireoideano com o sistema α2 adrenérgico no crescimento ósseo endocondral: uma avaliação em cultura de órgão. [Tese (Doutorado em Ciências Morfofuncionais) ]. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo; 2017.

Contact Info

Product

Resources

About

Reduction by propranolol of urinary hydroxyproline excretion in human hyperthyroidism: A beta-receptor blockade effect or a membrane stabilizing mechanism?

Cited by 8 publications

References 15 publications

Thyroid hormone interacts with the sympathetic nervous system to modulate bone mass and structure in young adult mice

Thyroid hormone interacts with the sympathetic nervous system to modulate bone mass and structure in young adult mice

Propranolol and Thyroid Hormone Metabolism

Estudo da interação do Hormônio Tireoideano com o sistema &#945;2 adrenérgico no crescimento ósseo endocondral: uma avaliação em cultura de órgão. [Tese (Doutorado em Ciências Morfofuncionais) ]. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo; 2017.

Contact Info

Product

Resources

About

Estudo da interação do Hormônio Tireoideano com o sistema α2 adrenérgico no crescimento ósseo endocondral: uma avaliação em cultura de órgão. [Tese (Doutorado em Ciências Morfofuncionais) ]. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo; 2017.