2016
DOI: 10.1021/acsami.5b10867
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Reduction-Degradable Polymeric Micelles Decorated with PArg for Improving Anticancer Drug Delivery Efficacy

Abstract: In this study, five kinds of reduction-degradable polyamide amine-g-polyethylene glycol/polyarginine (PAA-g-PEG/PArg) micelles with different proportions of hydrophilic and hydrophobic segments were synthesized as novel drug delivery vehicles. Polyarginine not only acted as a hydrophilic segment but also possessed a cell-penetrating function to carry out a rapid transduction into target cells. Polyamide amine-g-polyethylene glycol (PAA-g-PEG) was prepared for comparison. The characterization and antitumor effe… Show more

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Cited by 35 publications
(31 citation statements)
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“…. Polyarginine molecules, which consist of 5–11 sequentially arranged arginines, have been shown to effectively penetrate the cell membrane, and R8 peptide can be internalized into cells most efficiently 25 . However, studies 26.…”
Section: Introductionmentioning
confidence: 99%
“…. Polyarginine molecules, which consist of 5–11 sequentially arranged arginines, have been shown to effectively penetrate the cell membrane, and R8 peptide can be internalized into cells most efficiently 25 . However, studies 26.…”
Section: Introductionmentioning
confidence: 99%
“…Cancer is considered as one of the world's most life-threatening diseases with millions of new cases reported every year [1,2]. Even though the extensive research has resulted in advanced understanding of cancer, development of more sensitive detection methods and invention of chemotherapy drugs with superior efficacy compared to previous discoveries, the ability to deliver the drug molecules to the tumor tissue and specifically to the intracellular compartment of the cancer cells remains a challenge [3].…”
Section: Introductionmentioning
confidence: 99%
“…Further, the availability of react-able functional groups on dendrimer surface allows them to be anchored by a variety of peptides/ligands/antibodies to target cancer cells [18,19]. In general, the nanocarrier systems passively enter the tumor tissue via leaky vasculature by a phenomenon known as enhanced permeation and retention (EPR) effect [1,20,21]. However, following accumulation in the tumor microenvironment by EPR effect, the drug-loaded nanocarriers need to translocate through the cell membrane to reach the intracellular compartment to exert the therapeutic potential.…”
Section: Introductionmentioning
confidence: 99%
“…The micelle particles were found to be safe and compatible for drug delivery application. Micelles composition and its surface properties play an essential role in its overall activity in vitro and in vivo …”
Section: Nanoparticles Used In Cancer Therapymentioning
confidence: 99%
“…Micelles composition and its surface properties play an essential role in its overall activity in vitro and in vivo. 57 Hybrid nanoparticles are futuristic nanocarriers that may either be lipid-polymer nanoparticles or solid liposomal nanoparticles. They have a core made up of metallic/ polymeric molecules, and Corona made up of lipid layers resembling a micellar structure.…”
Section: Other Nanocarrier Systemsmentioning
confidence: 99%