Reduction/Dissolution of a β‐MnOOH Nanophase in the Ferritin Cavity To Yield a Highly Sensitive, Biologically Compatible Magnetic Resonance Imaging Agent

Kálmán, Ferenc K.; Crich, Simonetta Geninatti; Aime, Silvio

doi:10.1002/anie.200904731

Cited by 37 publications

(16 citation statements)

References 29 publications

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“…Kalman et al produced a manganese-based MRI contrast agent by partial reduction/dissolution of solid β–MnOOH inside apoferritin cavities. The resulting conjugates contain up to 300–400 Mn(II) aqua ions in each apoferritin cavity, and a very high r1 relaxivity of 4,000–7,000 s −1 per apoferritin unit was observed with these nanoparticles [48]. …”

Section: Ferritins For Mr Imagingmentioning

confidence: 99%

Ferritins as nanoplatforms for imaging and drug delivery

Zhen

Tang

Todd

et al. 2014

Expert Opinion on Drug Delivery

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Introduction Due to unique architecture and surface properties, ferritin has emerged as an important class of biomaterial. Many studies suggest that ferritin and its derivatives hold great potential in a wide range of bio-applications. Areas covered In this review, we summarize recent progress on employing ferritins as a platform to construct functional nanoparticles for applications in magnetic resonance imaging (MRI), optical imaging, cell tracking, and drug delivery. Expert opinion As a natural polymer, ferritins afford advantages such as high biocompatibility, good biodegradability, and a relatively long plasma half-life. These attributes put ferritins ahead of conventional materials in clinical translation for imaging and drug delivery purposes.

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Section: Ferritins For Mr Imagingmentioning

confidence: 99%

Ferritins as nanoplatforms for imaging and drug delivery

Zhen

Tang

Todd

et al. 2014

Expert Opinion on Drug Delivery

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“…In vitro , the protein shell called apoferritin (ApoF) and the iron-filled protein called holoferritin (HoloF) have different affinities for divalent metal atoms also depending of the pH31. Moreover, ApoF was successfully used as a monodisperse and spherical-shaped biotemplate for the mineralization of various inorganic NPs including iron, cobalt, manganese, platinum, zinc, rare earths-doped yttrium-vanadate or gadolinium193135363738394041. The in vitro versatility of ferritin proteins to encapsulate different metals suggests that they could also play a role in vivo in the metabolism of various metallic NPs.…”

mentioning

confidence: 99%

Physiological Remediation of Cobalt Ferrite Nanoparticles by Ferritin

Volatron

Kolosnjaj‐Tabi

Javed

et al. 2017

Sci Rep

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Metallic nanoparticles have been increasingly suggested as prospective therapeutic nanoplatforms, yet their long-term fate and cellular processing in the body is poorly understood. Here we examined the role of an endogenous iron storage protein – namely the ferritin – in the remediation of biodegradable cobalt ferrite magnetic nanoparticles. Structural and elemental analysis of ferritins close to exogenous nanoparticles within spleens and livers of mice injected in vivo with cobalt ferrite nanoparticles, suggests the intracellular transfer of degradation-derived cobalt and iron, entrapped within endogenous protein cages. In addition, the capacity of ferritin cages to accommodate and store the degradation products of cobalt ferrite nanoparticles was investigated in vitro in the acidic environment mimicking the physiological conditions that are present within the lysosomes. The magnetic, colloidal and structural follow-up of nanoparticles and proteins in the lysosome-like medium confirmed the efficient remediation of nanoparticle-released cobalt and iron ions by ferritins in solution. Metal transfer into ferritins could represent a quintessential process in which biomolecules and homeostasis regulate the local degradation of nanoparticles and recycle their by-products.

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“…Unfortunately, when manganese is administrated intraveneously as MnCl 2 , it shows a low Lethal Dose 50 (LD 50 ) of 0.32 mmol/kg in mice [37]. An Mn-loaded HoS-apoferritin system (Mn-Apo) was proposed by Kalman et al [38] to combine low toxicity with high efficacy. Following a previously reported procedure [39], MnOOH-loaded apoferritin was prepared by incubating the protein at pH 9 in MnCl 2 solution under air.…”

Section: Mn-loaded Apoferritinmentioning

confidence: 99%

Ferritin: A Platform for MRI Contrast Agents Delivery

et al. 2019

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The search for high relaxivities and increased specificity continues to be central to the development of paramagnetic contrast agents for magnetic resonance imaging (MRI). Ferritin, due to its unique surface properties, architecture, and biocompatibility, has emerged as a natural nanocage that can potentially help to reach both these goals. This review aims to highlight recent advances in the use of ferritin as a nanoplatform for the delivery of metal-based MRI contrast agents (containing Gd3+, Mn2+, or Fe2O3) alone or in combination with active molecules used for therapeutic purposes. The collected results unequivocally show that the use of ferritin for contrast agent delivery leads to more accurate imaging of cancer cells and a significantly improved targeted therapy.

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Reduction/Dissolution of a β‐MnOOH Nanophase in the Ferritin Cavity To Yield a Highly Sensitive, Biologically Compatible Magnetic Resonance Imaging Agent

Cited by 37 publications

References 29 publications

Ferritins as nanoplatforms for imaging and drug delivery

Ferritins as nanoplatforms for imaging and drug delivery

Physiological Remediation of Cobalt Ferrite Nanoparticles by Ferritin

Ferritin: A Platform for MRI Contrast Agents Delivery

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