Reduction in BOLD fMRI response to primary visual stimulation following alcohol ingestion

Levin, Jonathan M.; Ross, Marjorie H.; Mendelson, Jack H.; Kaufman, Marc J.; Lange, Nicholas; Maas, Luis C.; Mello, Nancy K.; Cohen, Bruce M.; Renshaw, Perry F.

doi:10.1016/s0925-4927(98)00022-5

Cited by 105 publications

(75 citation statements)

References 45 publications

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“…Global changes (more specifically decreases) in fMRI signal changes are likely confounded by such vasoactive changes. A previous fMRI study reported that alcohol resulted in a significant activation decrease in visual areas, slightly more on the right side (Levin et al, 1998). We did not find significant global alcohol-related changes for the driving paradigm (see, for example, the yellow time courses in Figure 5).…”

Section: Discussioncontrasting

confidence: 56%

Alcohol Intoxication Effects on Simulated Driving: Exploring Alcohol-Dose Effects on Brain Activation Using Functional MRI

Calhoun

Pekar

Pearlson

2004

Neuropsychopharmacol

173

143

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Driving while intoxicated is a major public health problem. We investigated impaired driving using a simulated driving skill game that presents an 'in-car' view of a road and a readout of speed. We explored brain activation and behavioral alterations from baseline at two blood alcohol concentrations (BACs). Participants received single-blind individualized doses of beverage alcohol designed to produce blood alcohol content (BAC) of 0.04 and 0.08 or placebo. Scanning occurred on a 1.5 Tesla Philips MRI scanner after training to asymptote performance. Analysis was performed using independent component analysis (ICA) to isolate systematically nonoverlapping 'networks' and their time courses. Imaging results revealed seven separate driving-related brain networks with different time courses. Several significant findings were observed for the imaging data. First, dose-dependent functional magnetic resonance imaging (fMRI) changes were revealed in orbitofrontal (OF) and motor (but not cerebellar) regions; visual and medial frontal regions were unaffected. Second, cerebellar regions were significantly associated with driving behavior in a dose-dependent manner. Finally, a global disruptive effect of alcohol on the ICA time courses was observed with highly significant differences in OF and motor regions. Alcohol thus demonstrated some behavioral effects and unique, disruptive, dose-dependent effects on fMRI signal within several brain circuits. The fMRI data also suggest that the deficits observed in alcohol intoxication may be modulated primarily through OF/anterior cingulate, motor and cerebellar regions as opposed to attentional areas in frontoparietal cortex.

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Section: Discussioncontrasting

confidence: 56%

Alcohol Intoxication Effects on Simulated Driving: Exploring Alcohol-Dose Effects on Brain Activation Using Functional MRI

Calhoun

Pekar

Pearlson

2004

Neuropsychopharmacol

173

143

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“…These relative fMRI responses are highly sensitive to baseline physiological parameters such as CBF, CBV, tissue oxygenation, and oxidative metabolism (Corfield et al, 2001;Ramsay et al, 1993). Factors that affect these physiological parameters are numerous and include anesthetics, respiration rate, blood pressure, endogenous hormones, emotional states, diseases, drugs of abuse, and many commonly ingested substances such as caffeine (Dager et al, 1999), nicotine (Jacobsen et al, 2002), and alcohol (Levin et al, 1998). These observations suggest caution when comparing fMRI results across subjects whose baseline physiological parameters may differ.…”

Section: Introductionmentioning

confidence: 99%

Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals

2005

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Functional magnetic resonance imaging (fMRI) was used to investigate the effects of inspired hypoxic, hyperoxic, and hypercapnic gases on baseline and stimulus-evoked changes in blood oxygenation level-dependent (BOLD) signals, cerebral blood flow (CBF), and the cerebral metabolic rate of oxygen (CMRO 2 ) in spontaneously breathing rats under isoflurane anesthesia. Each animal was subjected to a baseline period of six inspired gas conditions (9% O 2 , 12% O 2 , 21% O 2 , 100% O 2 , 5% CO 2 , and 10% CO 2 ) followed by a superimposed period of forepaw stimulation. Significant stimulus-evoked fMRI responses were found in the primary somatosensory cortices. Relative fMRI responses to forepaw stimulation varied across gas conditions and were dependent on baseline physiology, whereas absolute fMRI responses were similar across moderate gas conditions (12% O 2 , 21% O 2 100% O 2 , and 5% CO 2 ) and were relatively independent of baseline physiology. Consistent with data obtained using well-established techniques, baseline and stimulus-evoked CMRO 2 were invariant across moderate physiological perturbations thereby supporting a CMRO 2 -fMRI technique for non-invasive CMRO 2 measurement. However, under 9% O 2 and 10% CO 2 , stimulus-evoked CBF and BOLD were substantially reduced and the CMRO 2 formalism appeared invalid, likely due to attenuated neurovascular coupling and/or a failure of the model under extreme physiological perturbations. These findings demonstrate that absolute fMRI measurements help distinguish neural from non-neural contributions to the fMRI signals and may lend a more accurate measure of brain activity during states of altered basal physiology. Moreover, since numerous pharmacologic agents, pathophysiological states, and psychiatric conditions alter baseline physiology independent of neural activity, these results have implications for neuroimaging studies using relative fMRI changes to map brain activity.

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“…Several studies have also revealed that medications and food intake can affect the BOLD signal. For Handwerker, Daniel A 4 example, alcohol consumption increases CBF and the resting BOLD signal and may decrease the BOLD difference between rest and active conditions (Levin, et al 1998). …”

Section: Introductionmentioning

confidence: 99%

Reducing vascular variability of fMRI data across aging populations using a breathholding task

Handwerker¹,

Gazzaley²,

Inglis³

et al. 2006

Human Brain Mapping

129

174

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The magnitude and shape of Blood Oxygen Level Dependent (BOLD) responses in functional Magnetic Resonance Imaging (fMRI) studies vary across brain regions, subjects, and populations. This variability may be secondary to neural activity or vasculature differences, thus complicating interpretations of BOLD signal changes in fMRI experiments. We compare the BOLD responses to neural activity and a vascular challenge and test a method to dissociate these influences in 26 younger subjects (ages 18-36) and 24 older subjects (ages 51-78). Each subject performed a visuomotor saccade task (a vascular response to neural activity) and a breath holding task (vascular dilation induced by hypercapnia) during separate runs in the same scanning session. For the saccade task, signal magnitude showed a significant decrease with aging in FEF, SEF, and V1, and a delayed time-to-peak with aging in V1. The signal magnitudes from the saccade and hypercapnia tasks showed significant linear regressions within subjects and across individuals and populations. These two tasks had weaker, but sometimes significant, linear regressions for time-to-peak and coherence phase measures. The significant magnitude decrease with aging in V1 remained after dividing the saccade task magnitude by the hypercapnia task magnitude implying that the signal decrease is neural in origin. These findings may lead to a method to identify vascular reactivity induced differences in the BOLD response across populations and the development of methods to account for the influence of these vasculature differences in a simple, noninvasive manner.Handwerker, Daniel A 3

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Reduction in BOLD fMRI response to primary visual stimulation following alcohol ingestion

Cited by 105 publications

References 45 publications

Alcohol Intoxication Effects on Simulated Driving: Exploring Alcohol-Dose Effects on Brain Activation Using Functional MRI

Alcohol Intoxication Effects on Simulated Driving: Exploring Alcohol-Dose Effects on Brain Activation Using Functional MRI

Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals

Reducing vascular variability of fMRI data across aging populations using a breathholding task

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