Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach

Tovar, Juscelino; Mello, Vanessa D. de; Nilsson, Anne; Johansson, Maria; Paananen, Jussi; Lehtonen, Marko; Hanhineva, Kati; Björck, Inger

doi:10.1002/mnfr.201600552

Cited by 30 publications

(34 citation statements)

References 32 publications

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“…We also found a putative marker of fish intake, CMPFP, to be associated with lower odds of CD. There is a large epidemiological literature linking fish consumption to lower CD and although CMPFP did not significantly correlate with fish intake in our sample, CMPFP was found increased after consuming fish‐rich Mediterranean and Nordic diets in two untargeted metabolomics studies, and was recently confirmed as a potential biomarker of fish . Moreover, we found an unidentified ion highly correlated with (red) wine intake, to be associated with lower odds of CD.…”

Section: Discussioncontrasting

confidence: 58%

Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort

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Lefèvre‐Arbogast

González‐Domínguez

et al. 2019

Molecular Nutrition Food Res

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Scope Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. Methods and results A case‐control study nested in the prospective Three‐City study includes participants aged ≥65 years and initially free of dementia. A total of 209 cases of cognitive decline and 209 controls (matched for age, gender, education) with slower cognitive decline over up to 12 years are contrasted. Using untargeted metabolomics and bootstrap‐enhanced penalized regression, a baseline serum signature of 22 metabolites associated with subsequent cognitive decline is identified. The signature includes three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium‐chain acylcarnitines, glycodeoxycholic acid, lysoPC(18:3), trimethyllysine, glucose, cortisol, creatinine, and arginine. Adding the 22 metabolites to a reference predictive model for cognitive decline (conditioned on age, gender, education and including ApoE‐ε4, diabetes, BMI, and number of medications) substantially increases the predictive performance: cross‐validated Area Under the Receiver Operating Curve = 75% [95% CI 70–80%] compared to 62% [95% CI 56–67%]. Conclusions The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging.

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Section: Discussioncontrasting

confidence: 58%

Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort

Low

Lefèvre‐Arbogast

González‐Domínguez

et al. 2019

Molecular Nutrition Food Res

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“…This observation is in line with the reported beneficial effects of Lovaza on regulation of lipid profiles in humans, suggesting that CMPF may be an active component of FO, contributing to the beneficial metabolic effects seen in humans. Interestingly, human studies have also revealed a strong correlation between elevated circulating CMPF and reduced plasma TG levels, associating CMPF with a role in regulating glycolipid metabolism …”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, human studies have also revealed a strong correlation between elevated circulating CMPF and reduced plasma TG levels, associating CMPF with a role in regulating glycolipid metabolism. [14][15][16] Mechanistically, CMPF was found to be an inhibitor of acetyl-coA carboxylase (ACC), the master regulator of fatty acid metabolism, as well as having the ability to induce the production of fibroblast growth factor 21 (FGF21). 9 CMPF's long-term preventive effect on HFDinduced hepatic lipid accumulation is absent in FGF21KO mice, suggesting that the long-term beneficial effect of CMPF on metabolism is FGF21 dependent.…”

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confidence: 99%

3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF) prevents high fat diet‐induced insulin resistance via maintenance of hepatic lipid homeostasis

Mohan

Brandt

Kim

et al. 2018

Diabetes Obesity Metabolism

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“…In previous studies, we have observed improved cardiometabolic markers in healthy at-risk individuals after 4–8 week intake of MFD targeting low-grade inflammation [7, 8]. The diet exerted also extensive impact on the plasma metabolome, particularly the lipidome [9]. However, whether these improvements can be associated with changes in the gut microbiota composition has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects

et al. 2017

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PurposeA multifunctional diet (MFD) targeting subclinical inflammation was developed as a tool to decrease risk factors for cardiometabolic disease in healthy “at-risk” individuals (BMI 25–33 kg/m2). MFD contains several components that are degraded in the colon by the microbiota, such as dietary fibers from rye, barley, oats and berries. It also contains soy beans, oily fish and plant stanols. In previous studies, we have observed improved cardiometabolic markers in healthy at-risk individuals after 4–8 week intake of MFD. However, whether these improvements can be associated with changes in the gut microbiota composition has not been investigated. In the present study, we analyzed the gut microbiota before and after an 8-week dietary intervention with MFD.MethodsCardiometabolic at-risk individuals (n = 47), between 51 and 72 years old and with a BMI of 25–33 kg/m2, were given either the MFD or a control diet lacking the functional (“active”) components for 8 weeks in a parallel, randomized design. Next-generation sequencing of bacterial 16S rRNA genes was used to analyze the gut microbiota composition.ResultsThe 8-week intervention with MFD did not significantly alter the gut microbiota composition at phylum or genus taxonomic levels, while LEfSE analysis identified increased abundance of Prevotella copri in the MFD group as compared to the control group. Treponema correlated positively with blood pressure. In contrast, Faecalibacterium showed a negative association with blood pressure, while Bilophila appeared to associate with a negative blood lipid profile.ConclusionsTaken together, results from the present study may be used in the further development of effective dietary concepts capable of reducing cardiometabolic risk markers in humans through a targeted modulation of the gut microbial community.Trial registration numberClinical Trials.gov NCT02148653.Electronic supplementary materialThe online version of this article (doi:10.1007/s00394-017-1563-3) contains supplementary material, which is available to authorized users.

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Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach

Abstract: The metabolomics approach revealed that consumption of MFD affected different areas of metabolism, highlighting the impact of a healthy diet on plasma metabolome. This seems linked to reduced cardiometabolic risk and provides mechanistic insight into the effects of MFD.

Cited by 30 publications

References 32 publications

Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort

Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort

3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF) prevents high fat diet‐induced insulin resistance via maintenance of hepatic lipid homeostasis

Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects

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