Reduction in Cardiovascular Death After Kidney Transplantation

Pilmore, Helen; Dent, Hannah; Chang, Sean; McDonald, S.; Chadban, Steven J.

doi:10.1097/tp.0b013e3181caeead

Cited by 190 publications

(153 citation statements)

References 25 publications

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…Compared with the general population, KTRs are at a 3-to 5-fold higher risk (2), with some improvement in recent years (3). Calcification of the arterial wall is a strong cardiovascular risk factor in the general population (4-7), in patients on dialysis (8) and in KTRs (9,10).…”

Section: Introductionmentioning

confidence: 99%

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

Dahle

Åsberg

Hartmann

et al. 2016

American Journal of Transplantation

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

Dahle

Åsberg

Hartmann

et al. 2016

American Journal of Transplantation

View full text Add to dashboard Cite

“…Although short-and intermediate-term graft survival has improved with the introduction of calcineurin inhibitors (CNIs) in the 1980s, the rate of graft failure beyond 10 years posttransplant has remained unchanged (2). Chronic allograft nephropathy (CAN; also defined as nonspecific interstitial fibrosis and tubular atrophy [IFTA]) and death with functioning graft (DFG) are the two most common causes of late graft loss, with cardiovascular disease (CVD) and cancer demonstrated to be the two most frequent causes of DFG (3,4). In Australia, 40% and 43% of graft loss are attributed to CAN and DFG, respectively (2).…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Conversion From Calcineurin Inhibitor to Mammalian Target of Rapamycin Inhibitors for Maintenance Immunosuppression in Kidney Transplant Recipients

Lim

Eris

Kanellis

et al. 2014

American Journal of Transplantation

126

View full text Add to dashboard Cite

“…We demonstrated that advanced age, increased SBP, serum osteoprotegerin levels to some extent, but CV disease still remains the leading cause of death in renal transplant recipients (22). Beside the factors mentioned above, why the Rtx patients are more prone to worse CV outcomes and why these anticipated events remain after Rtx are still unclear.…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Nementioning

confidence: 99%

The Relationship Between Osteoprotegerin/RANKL Axis and Arterial Stiffness in Osteopenic/Osteoporotic Renal Transplantation Recipients

Koçyiğit¹,

Türkmen²,

Doğan³

et al. 2015

Turk Neph Dial Transpl

View full text Add to dashboard Cite

OBJECTIVE: Cardiovascular diseases are the main reason of death in patients with renal transplantation (Rtx). Osteoprotegerin (OPG) is produced by osteoblasts and is linked to increased cardiovascular risk in Rtx. OPG acts as a decoy receptor binding receptor activator of nuclear factor kappa-B ligand (RANKL) and this interaction plays a role in bone resorption and vascular function. This study aimed to investigate the relation between OPG, RANKL, osteoporosis and arterial stiffness in Rtx patients. MATERIAL and METHODS:This cross-sectional study included 80 adult Rtx recipients. Femoral neck mineral density was obtained by dual-energy X-ray absorptiometry. Serum OPG and RANKL were measured by the ELISA method. Pulse-wave analysis was measured in the carotid and femoral arteries using a pulse wave velocity (PWV) machine. RESULTS:Patients were divided into two groups as normal (n:24) and osteopenia/osteoporosis group (n:56). Body mass index was significantly lower in the osteopenic/osteoporotic group compared to the normal group. Pulse wave velocity was positively correlated with age (r:0.204,p:0.072), osteoprotegerin (r:0.219,p:0.052), calcium x phosphate product (r:0.605,p:<0.001), and systolic blood pressure (r:0.198,p:0.058) and negatively correlated with RANKL (r:-0.261,p:0.020) and creatinine clearance (r:-0.220,p:0.051). PWV was independently predicted by calcium x phosphate product but not creatinine clearance, RANKL, osteoprotegerin and systolic blood pressure. CONCLUSION:In our study, serum calcium x phosphate product but not OPG and RANKL levels were found to be the main predictor of arterial stiffness in Rtx patients. KEY WORDS:Renal transplantation, Osteoporosis, Osteoprotegerin, RANKL, Pulse wave velocity ÖZ AMAÇ: Kardiyovasküler hastalıklar böbrek transplantasyonu (Btx) olan hastalarda mortalitenin ana nedenleri arasındadır. Osteoprotegerin (OPG), osteoblastlar tarafından üretilir ve BTx'li hastalarda artmış kardiyovasküler risk ile bağlantılıdır. Normal popülasyonda OPG, serumda NF-ĸB ligandının (RANKL) bir reseptörü olarak davranır ve bu etkileşimin kemik erimesi ve vasküler fonksiyonlar üzerinde önemli bir rol oynadığı tespit edilmiştir. Literatürde Btx'li hastalarda bu etkileşimle ilgili yeterli bilgi bulunmamaktadır. Bu nedenle, çalışmamızda Btx'li hastalarda OPG, RANKL, osteoporoz ve arteriyel sertlik arasındaki ilişki araştırılmıştır. GEREÇ ve YÖNTEMLER:Bu kesitsel çalışmaya 80 erişkin Btx'li hasta dahil edilmiştir. Femur boynu mineral yoğunluğu dual-enerji X-ışını soğurma (DEXA) yöntemiyle elde edildi. Serum OPG ve RANKL ELISA yöntemi ile ölçüldü. Nabız dalga analizi karotid ve nabız dalga hızı (NDH) makinesi kullanılarak femoral arterlerden ölçüldü. BULGULAR:Hastalar osteopeni/osteoporoz grubu (n:56) ve normal (n: 24) olarak iki gruba ayrıldı. Vücut kitle indeksi normal gruba göre osteopenik/osteoporotik grupta anlamlı olarak daha düşüktü. Nabız dalga hızı ile yaş (r: 0,204, p: 0,072), OPG (r: 0,219, p: 0,052), kalsiyumxfosfat çarpımı (r: 605, p <0,001) ve sistolik kan basıncı (r:...

show abstract

Reduction in Cardiovascular Death After Kidney Transplantation

Abstract: These trends suggest improvements in CVS risk management and outcomes in the kidney transplant population in Australia and New Zealand.

Cited by 190 publications

References 25 publications

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

A Systematic Review of Conversion From Calcineurin Inhibitor to Mammalian Target of Rapamycin Inhibitors for Maintenance Immunosuppression in Kidney Transplant Recipients

The Relationship Between Osteoprotegerin/RANKL Axis and Arterial Stiffness in Osteopenic/Osteoporotic Renal Transplantation Recipients

Contact Info

Product

Resources

About

Reduction in Cardiovascular Death After Kidney Transplantation

Abstract: These trends suggest improvements in CVS risk management and outcomes in the kidney transplant population in Australia and New Zealand.

Cited by 190 publications

References 25 publications

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

A Systematic Review of Conversion From Calcineurin Inhibitor to Mammalian Target of Rapamycin Inhibitors for Maintenance Immunosuppression in Kidney Transplant Recipients

The Relationship Between Osteoprotegerin/RANKL Axis and Arterial ￼Stiffness in Osteopenic/Osteoporotic Renal Transplantation Recipients

Contact Info

Product

Resources

About

The Relationship Between Osteoprotegerin/RANKL Axis and Arterial Stiffness in Osteopenic/Osteoporotic Renal Transplantation Recipients