2009
DOI: 10.1016/j.pscychresns.2008.11.006
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Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging

Abstract: The purpose of this preliminary study was to examine cerebral blood flow (CBF) as measured by arterial spin labeling (ASL) in tissue classified as white matter hyperintensities (WMH), normal appearing white matter, and grey matter. Seventeen healthy older adults received structural and ASL MRI. Cerebral blood flow was derived for three tissue types: WMH, normal appearing white matter, and grey matter. Cerebral blood flow was lower in WMH areas relative to normal appearing white matter, which in turn, was lower… Show more

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Cited by 134 publications
(139 citation statements)
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“…39,40 Although our study was conducted in an elderly population with hypertension in the Netherlands, approximately 70% in this age range have hypertension, 41 suggesting that our findings may apply to a large part of the general population. Findings of similar studies were in small or selected populations, 7,10,11,15 and may be less readily translatable to the general elderly community. Our finding that CBF values within WMHs are lower in participants with higher WMH volume is in line with previous findings.…”
Section: Discussionmentioning
confidence: 97%
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“…39,40 Although our study was conducted in an elderly population with hypertension in the Netherlands, approximately 70% in this age range have hypertension, 41 suggesting that our findings may apply to a large part of the general population. Findings of similar studies were in small or selected populations, 7,10,11,15 and may be less readily translatable to the general elderly community. Our finding that CBF values within WMHs are lower in participants with higher WMH volume is in line with previous findings.…”
Section: Discussionmentioning
confidence: 97%
“…1,5,6 In agreement, CBF within WMHs is lower compared with normal-appearing WM (NAWM). [7][8][9][10][11][12][13][14] Whether WMHs are associated with a lower cerebral perfusion in general, also involving the surrounding NAWM and gray matter, is unclear. Some findings suggest that WMHs may relate to lower whole-brain or GM perfusion, 7,11,15,16 and WMHs have been associated with reduced blood flow velocity in the large intracranial arteries, outside the WM.…”
mentioning
confidence: 99%
“…20 As a result, cerebrovascular resistance in areas with WMHs will be impaired, which might result in CBF decline. 8,21,22 Both deep and periventricular WMHs were associated with decline in CBF. Several studies have attributed different causes and behavioral consequences to the 2 classes of WMHs.…”
Section: Discussionmentioning
confidence: 99%
“…This ischemic mechanism has been demonstrated in animals 2,3 ; however, human studies studying the effect of lower CBF on development of WMHs and lacunes are scarce and cross-sectional. [4][5][6][7][8] A possible explanation for the lack of an association between baseline pCBF and progression of WMHs and lacunes could be that they represent different pathological processes. The development of WMHs and lacunes could be the result of mechanisms unrelated to hemodynamic processes, such as neurodegeneration and genetic predisposition.…”
Section: Discussionmentioning
confidence: 99%
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