Reduction in GABAB on glia induce Alzheimer’s disease related changes

Osse, Amanda M. Leisgang; Pandey, Ravi S.; Wirt, Ryan A.; Ortiz, Andrew A.; Salazar, Arnold; Kimmich, Michael; Strom, Erin N.; Oblak, Adrian L.; Lamb, Bruce T.; Hyman, James M.; Carter, Gregory W.; Kinney, Jefferson W.

doi:10.1016/j.bbi.2023.03.002

Cited by 6 publications

(3 citation statements)

References 145 publications

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“…GABA B agonists promoted proliferation and neuronal differentiation in neural progenitor cells that expressed both R1 and R2 subunits, but not in R1-null cells [ 18 ]. Decreased GABA B Rs on macrophages leads to several changes observed in AD model mouse [ 19 ]. Those suggest that GABA B receptors in the hippocampus play an important role in suppressing in neurodegeneration and probably regeneration in the AD brain.…”

Section: Discussionmentioning

confidence: 99%

Long-lasting increases in GABAB receptor subunit levels in hippocampal dentate gyrus of mice with a single systemic injection of trimethyltin

Onishi,

Yamamura,

Hosogi

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Long-lasting increases in GABAB receptor subunit levels in hippocampal dentate gyrus of mice with a single systemic injection of trimethyltin

Onishi,

Yamamura,

Hosogi

et al. 2024

Heliyon

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“…38 The previous study demonstrated that GABA is the main inhibitory neurotransmitter in the human cortex and its decrease is positively associated with neurodegenerative diseases. 96 Therefore, the regulation of GABA levels or interaction with its receptor also contributed to the neuroprotective effects of thymol. In summary, thymol modulates neurotransmitter levels and activity, contributing to its neuroprotective effects and potential therapeutic use in neurodegenerative diseases.…”

Section: Modulation Of Neurotransmittersmentioning

confidence: 99%

“…Thymol supplementation has been associated with increased GABA levels and decreased AchE activity, reducing neuronal cell apoptosis and neurotoxicity . The previous study demonstrated that GABA is the main inhibitory neurotransmitter in the human cortex and its decrease is positively associated with neurodegenerative diseases . Therefore, the regulation of GABA levels or interaction with its receptor also contributed to the neuroprotective effects of thymol.…”

Section: Critical Actional Mechanisms Of Thymol’s Neuroprotectionmentioning

confidence: 99%

Thymol as a Potential Neuroprotective Agent: Mechanisms, Efficacy, and Future Prospects

Peng,

Zhang,

Sharma

et al. 2024

J. Agric. Food Chem.

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Neurodegenerative diseases pose a growing global health challenge, with limited effective therapeutic options. Mitochondrial dysfunction, oxidative stress, neuroinflammation, apoptosis, and autophagy are common underlying mechanisms in these diseases. Thymol is a phenolic monoterpene compound that has gained attention for its diverse biological properties, including antioxidant, anti-inflammatory, and immunomodulatory activities. Thymol supplementation could provide potential neuroprotection and improve cognitive deficits, depressant-like effects, learning, and memory impairments in rodents. Mechanistic investigations reveal that the neuroprotective effects of thymol involve the improvement of oxidative stress, mitochondrial dysfunction, and inflammatory response. Several signaling pathways, including mitochondrial apoptotic, NF-κB, AKT, Nrf2, and CREB/BDNF pathways are also involved. In this review, the neuroprotective effects of thymol, the potential molecular mechanisms, safety, applications, and current challenges toward development as a neuroprotective agent were summarized and discussed. We hope that this review provides valuable insights for the further development of this promising natural product as a promising neuroprotective agent.

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Somatostatin and the pathophysiology of Alzheimer’s disease

Almeida

2024

Ageing Research Reviews

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Reduction in GABAB on glia induce Alzheimer’s disease related changes

Cited by 6 publications

References 145 publications

Long-lasting increases in GABAB receptor subunit levels in hippocampal dentate gyrus of mice with a single systemic injection of trimethyltin

Long-lasting increases in GABAB receptor subunit levels in hippocampal dentate gyrus of mice with a single systemic injection of trimethyltin

Thymol as a Potential Neuroprotective Agent: Mechanisms, Efficacy, and Future Prospects

Somatostatin and the pathophysiology of Alzheimer’s disease

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