Reduction in Histone H3 Acetylation and Chromatin Remodeling in Corneas of Alloxan-Induced Diabetic Rats

Herencia-Bueno, Karina E; Aldrovani, Marcela; Crivelaro, Roberta Martins; Thiesen, Roberto; Barros-Sobrinho, Alexandre A F; Claros-Chacaltana, Flor D Y; Padua, Iván Ricardo Martínez; Santos, Daniela Moura dos; Laus, José Luiz

doi:10.1097/ico.0000000000001533

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Interactions between INSR and the voltage-dependent anion channel-1 (VDAC1) prevent fragmentation and altered polarization of mitochondria, as well as facilitate PINK-1-mediated mitophagy [ 22 ]. In diabetic rats, the process of histone H3 acetylation is reduced in corneal epithelial cells, resulting in compacted chromatin organization in nuclei characterized by increased size and elevated DNA ploidy [ 48 ].…”

Section: The Role Of Insulin and Effect Of Diabetesmentioning

confidence: 99%

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

Woronkowicz,

Roberts,

Skopiński

2024

Biology

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The corneal epithelium, comprising three layers of cells, represents the outermost portion of the eye and functions as a vital protective barrier while concurrently serving as a critical refractive structure. Maintaining its homeostasis involves a complex regenerative process facilitated by the functions of the lacrimal gland, tear film, and corneal nerves. Crucially, limbal epithelial stem cells located in the limbus (transitional zone between the cornea and the conjunctiva) are instrumental for the corneal epithelium integrity by replenishing and renewing cells. Re-epithelialization failure results in persistent defects, often associated with various ocular conditions including diabetic keratopathy. The insulin-like growth factor (IGF) system is a sophisticated network of insulin and other proteins essential for numerous physiological processes. This review examines its role in maintaining the corneal epithelium homeostasis, with a special focus on the interplay with corneal limbal stem cells and the potential therapeutic applications of the system components.

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Section: The Role Of Insulin and Effect Of Diabetesmentioning

confidence: 99%

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

Woronkowicz,

Roberts,

Skopiński

2024

Biology

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“…In addition, in a rat model of type I diabetes (utilizing alloxan induction), Herencia-Bueno et al (2018) found diabetes reduced histone H3 acetylation in the cornea, leading to aberrant chromatin organization 58 . Further research is needed to elucidate the implication of this change in corneas of patients with diabetes.…”

Section: Histone Modification and Granular Corneal Dystrophy And Othementioning

confidence: 99%

Epigenetic regulation of anterior segment diseases and potential therapeutics

et al. 2020

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In recent years, technological advances in sequencing have accelerated our understanding of epigenetics in ocular development and ophthalmic diseases. We now know that epigenetic modifications are necessary for normal ocular development and biological processes such as corneal wound healing and ocular surface repair, while aberrant epigenetic regulation underlies the pathogenesis of a wide range of ocular diseases, including cataracts and various diseases of the ocular surface. As the epigenetics of the eye is a constantly changing field of medicine, this comprehensive review focuses on innovations and scientific discoveries related to epigenetic control of anterior segment diseases that were published in the English literature in the past five years. These recent studies attempt to elucidate therapeutic targets for the anterior segment pathological processes. Already, recent studies have shown therapeutic potential in targeting epigenetic mechanisms of ocular disease, and new epigenetic therapies are on the verge of being introduced to clinical practice. New drug targets can potentially emerge as we make further discoveries within this field.

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