Reduction in interhemispheric functional connectivity in the dorsal visual pathway in unilateral acute open globe injury patients: a resting-state fMRI study

Abstract

This study investigated the changes in interhemispheric functional connectivity (FC) of the whole brain in open globe injury (OGI) patients, using voxel-mirrored homotopic connectivity (VMHC), and their relationships with clinical features. Totally, 16 male and 2 female acute OGI patients and 18 sex, age, and education-matched healthy volunteers were enrolled in the study. All subjects were scanned through functional magnetic resonance imaging (fMRI). Receiver operating characteristic (ROC) curves analyses had been used to identify the VMHC in these brain areas could be used as biomarkers to distinguish OGI and from healthy control (HC). The mean VMHC values in multiple brain areas and clinical OGI manifestations were evaluated with a Pearson correlation analysis. OGI patients had significantly decreased VMHC in the bilateral calcarine/lingual/cuneus (BA18, 19, 30) and middle occipital gyrus (BA18, 19). The OGI patients had abnormal interhemispheric FC in the dorsal visual pathway, which may represent the pathophysiological mechanism that underlies acute vision loss after OGI.

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study</p>

“…Previous studies investigating ophthalmological diseases (Table 4) revealed abnormal spontaneous FC between the V1 and other regions in patients with anisometropic amblyopia, 12 blindness, [13][14][15] glaucoma, 8,16,7,16 exotropia, 10,9 acute open globe injury, 17 and retinitis pigmentosa. 18 The FC in the left V1 and right FG, bilateral cuneus, and left precuneus was significantly decreased in the NVG group compared with that reported in the HC group ( Figure 5).…”

“…37 The same changes in brain function have been observed in eye diseases. Investigators illustrated that the FC of the cuneus decreased in glaucoma, 8,16,7,16 acute open globe injury, 17 and monocular blindness. 15 Consistent with these previous studies, in the present study, we detected a significant reduction in FC between the bilateral V1 and bilateral cuneus, indicating the severity of NVG and visual quality.…”

Intrinsic functional connectivity alterations of the primary visual cortex in patients with proliferative diabetic retinopathy: a seed-based resting-state fMRI study

“… 23 Similarly, acute open globe injury patients exhibited a reduction of brain neural homogeneity in the cuneus. 41 Xia et al revealed that the ALFF value decreased in both the precuneus and the cortex related to vision in T2DM patients, which confirmed that there are abnormal spontaneous activities in distinct cerebrum regions in these patients. 42 A clinical study of patients with retinal degeneration found that the calcarine showed significant atrophic changes.…”

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study</p>

“…37 Huang et al 23 detected a significant decline in brain neural homogeneity in the cuneus of individuals with retinal detachment; of note, a similar decreasing trend in the cuneus was reported in acute open globe injury. 38 Furthermore, patients with monocular blindness exhibited lower values of voxel-mirrored homotopic connectivity in the cuneus. Recent studies have shown that a decrease in FC between the bilateral V1 and right cuneus can indicate functional deficits in patients with CU, providing new evidence that CU may cause cuneus dysfunction.…”