Reduction in mucosal barrier markers with soy protein diet but not probiotic in DSS‐treated mice

MacDonald, Ruth S.; Jiang, Huanyi; Przybyszewski, Joseph; Mitra, Debjani

doi:10.1096/fasebj.25.1_supplement.435.6

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“…Administration of Lactobacillus rhamnosus GG, significantly relieved DSS‐induced colitis, its effect was related to altering the expression of the MUC and TFF genes. The soluble‐protein HM0539 derived from LGG, showed significant protective effects against murine colitis, the protective function involved in the modulation of inflammatory responses (Li et al, 2020 ; Macdonald et al, 2011 ). Therefore, exploring safe therapeutic targets with higher efficacy and lower incidence of adverse reactions is still a focus of attention in the treatment of IBD.…”

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confidence: 99%

Chimonanthus salicifolius extract alleviates DSS‐induced colitis and regulates gut microbiota in mice

Chen

2023

Food Science & Nutrition

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Ulcerative colitis is a chronic and recurrent gastrointestinal intestinal disease accompanied by inflammatory disorders, immunologic inadequacy, and intestinal flora dysbiosis, and current therapeutic pharmaceuticals have limited side effects. In this study, we revealed the extraction method of Chimonanthus salicifolius, analyzed the main component, compared the effect of its extract, Lactobacillus, and conventional drugs with different properties on DSS (dextran sodium sulfate)‐induced colitis, and indicated extract regulatory properties of inestinal flora. A colitis model was established on experimental design, and BALB/c mice (male, 7 weeks old) were randomly assigned to five groups (n = 10): control, DSS model, Chimonanthus salicifolius extract (CSE), Lactobacillus rhamnosus GG (LGG), and 5‐aminosalicylic acid (5‐ASA) groups. The three treatments could alleviate the symptoms and remit inflammation induced by DSS, in which CSE and LGG groups could both decrease the proinflammatory cytokine IL‐6, IL‐8, and TNF‐α levels and increase anti‐inflammatory cytokines IL‐10 and TGF‐β. The CSE intervention significantly promoted the higher production of butyric acid than LGG and 5‐ASA groups (p < .05) after DSS challenge. Analysis of intestinal flora showed that CSE administration remarkably decreased the relative abundance of pathogenic bacteria Heliobacteriaceae and Peptococcaceae and exhibited higher abundance of Lactobacillaceae and Bifidobacterium than LGG in intestinal tract of mice (p < .05). These findings indicated that Chimonanthus salicifolius extract may have been beneficial for preventing and treating colitis.

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Section: Introductionmentioning

confidence: 99%

Chimonanthus salicifolius extract alleviates DSS‐induced colitis and regulates gut microbiota in mice

Chen

2023

Food Science & Nutrition

View full text Add to dashboard Cite

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Reduction in mucosal barrier markers with soy protein diet but not probiotic in DSS‐treated mice

Cited by 1 publication

References 0 publications

Chimonanthus salicifolius extract alleviates DSS‐induced colitis and regulates gut microbiota in mice

Chimonanthus salicifolius extract alleviates DSS‐induced colitis and regulates gut microbiota in mice

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