Reduction in regional cerebral blood flow during normal aging in man.

Melamed, Eldad; Lavy, S; Bentin, Shlomo; Cooper, Gerald R.; Rinot, Yosef

doi:10.1161/01.str.11.1.31

Cited by 259 publications

(122 citation statements)

References 21 publications

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“…This indication of frontal dys function is interesting to relate to the findings of Te rry et al (1987), who found a significant shrinkage of large neurons together with a decre-ment in the neuron-glia ratio in midfrontal and su perior temporal areas in normal aged brains. These results thus support the suggestion by Melamed et al (1980) that the age-related reduction in frontal blood flow is related to neuronal loss.…”

Section: Regional Distribution Valuessupporting

confidence: 91%

Sex Differences in Regional Cerebral Blood Flow

Rodriguez¹,

Warkentin

Risberg

et al. 1988

J Cereb Blood Flow Metab

248

126

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Summary: Regional cerebral blood flow was measured by the 133-xenon inhalation method during resting in 38 healthy men and 38 healthy women matched pairwise for age in the range 18-72 years. The results showed 11 % higher global flow level in the women in all ages. A sim ilar and significant regression of flow by age was seen for both sexes. The regional flow distribution also showed some sex-related differences. Frontal regions showed an asymmetry in the men with higher values on the right

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Section: Regional Distribution Valuessupporting

confidence: 91%

Sex Differences in Regional Cerebral Blood Flow

Rodriguez¹,

Warkentin

Risberg

et al. 1988

J Cereb Blood Flow Metab

248

126

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“…The infl uence of age on cerebral blood fl ow parameters is a well-known phenomenon (Naritomi et al 1979;Melamed et al 1980). The decline in cerebral blood fl ow with advancing age may be associated with certain changes in cerebrovascular hemodynamics such as decreased metabolic demands, higher hematocrit and lower partial pressure of carbon dioxide levels (Melamed et al 1980), vessel-size changes (Kusunoki et al 1999), and lower cardiac output (Safar 1990).…”

Section: Discussionmentioning

confidence: 99%

Normal Blood Flow Velocities of Basal Cerebral Arteries Decrease with Advancing Age: A Transcranial Doppler Sonography Study

Demirkaya

Uluç

Bek

et al. 2008

Tohoku J. Exp. Med.

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Transcranial Doppler sonography (TCD) is a non-invasive diagnostic tool enabling evaluation of blood fl ow characteristics of basal intracerebral vessels via thin calvarian regions. Several factors may affect the normal values of cerebral hemodynamic parameters, and standard reference values for each laboratory are needed for precise interpretation of the results. The aims of this study were to determine normal values of fl ow velocities of basal cerebral arteries of our TCD laboratory, and to study the infl uence of age and gender on normal values. We studied 63 healthy volunteers (30 male and 33 females; age range, 5 -69 years old) with TCD with a 2-MHz transcranial probe. The subjects were divided into 7 age groups: 5-10 years, 11-20 years, 21-30 years, 31-40 years, 41-50 years, 51-60 years and > 60 years. Mean velocity (V mean), peak systolic velocity (PSV), and end-diastolic velocities (EDV) were determined in middle, anterior and posterior cerebral arteries. No signifi cant gender difference was found. However, there was a decrease in blood fl ow velocities in all vessels with advancing age, which was signifi cant when subjects older than 40 years and 40 years old were compared. V mean, PSV and EDV values were highest in the age group of 5 -10 years old and lowest in volunteers older than the age of 60 ( p < 0.05). As a conclusion, fl ow velocities in basal cerebral arteries range widely and are signifi cantly age-related. Age matching of TCD data is a requirement for clinically relevant conclusions.transcranial Doppler sonography; basal; cerebral arteries; normal values; healthy subjects. Tohoku

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“…While some studies reported no gender differences in CBF (Melamed et al, 1980;Hannay et al, 1983), others found that women had higher rates of CBF than men and that was related to age, since by the sixth decade (Gur et al, 1987) men and women had similar flow rates. PET (Rodriguez et al, 1988;Gur and Gur, 1990;Jaeger et al, 1998;Ragland et al, 2000) and fMRI (Kastrup et al, 1999) studies found differences in activation during resting state (Rodriguez et al, 1988), cognitive tasks (Gur and Gur, 1990;Jaeger et al, 1998;Ragland et al, 2000), or visual stimulation (Kastrup et al, 1999).…”

Section: Gender Differences In Activationmentioning

confidence: 94%

Distinct pathways involved in sound recognition and localization: A human fMRI study

Maeder¹,

Meuli²,

Adriani³

et al. 2000

NeuroImage

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Evidence from psychophysical studies in normal and brain-damaged subjects suggests that auditory information relevant to recognition and localization are processed by distinct neuronal populations. We report here on anatomical segregation of these populations. Brain activation associated with performance in sound identification and localization was investigated in 18 normal subjects using fMRI. Three conditions were used: (i) comparison of spatial stimuli simulated with interaural time differences; (ii) identification of environmental sounds; and (iii) rest. Conditions (i) and (ii) required acknowledgment of predefined targets by pressing a button. After coregistering, images were normalized and smoothed. Activation patterns were analyzed using SPM99 for individual subjects and for the whole group. Sound recognition and localization activated, as compared to rest, inferior colliculus, medial geniculate body, Heschl gyrus, and parts of the temporal, parietal, and frontal convexity bilaterally. The activation pattern on the fronto-temporo-parietal convexity differed in the two conditions. Middle temporal gyrus and precuneus bilaterally and the posterior part of left inferior frontal gyrus were more activated by recognition than by localization. Lower part of inferior parietal lobule and posterior parts of middle and inferior frontal gyri were more activated, bilaterally, by localization than by recognition. Regions selectively activated by sound recognition, but not those selectively activated by localization, were significantly larger in women. Passive listening paradigm revealed segregated pathways on superior temporal gyrus and inferior parietal lobule. Thus, anatomically distinct networks are involved in sound recognition and sound localization.

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Reduction in regional cerebral blood flow during normal aging in man.

Cited by 259 publications

References 21 publications

Sex Differences in Regional Cerebral Blood Flow

Sex Differences in Regional Cerebral Blood Flow

Normal Blood Flow Velocities of Basal Cerebral Arteries Decrease with Advancing Age: A Transcranial Doppler Sonography Study

Distinct pathways involved in sound recognition and localization: A human fMRI study

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