Reduction in Size and Number of Plantar Verrucae in Human Immunodeficiency Virus–Infected Individuals After the Implementation of Highly Active Antiretroviral Therapy

Abstract

Study results indicate that the implementation of HAART has impacted the clinical manifestations of plantar verrucae in HIV-positive individuals. Further analyses with a larger number of patients are required to confirm and substantiate these findings.

HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management

“…infection is more common in the HIV-infected population than in the HIV-uninfected population as a result of both concomitant sexual transmission, and because HIV has been suggested to aid in HPV viral replication and tumor formation through upregulation of p27 expression and induction of cell proliferation (227,228). Immune system reconstitution has had an effect on nonmalignant and precursor lesions, including decreased size and number of plantar warts and decreased incidence rate of genital warts (229,230). However, with prolonged ART-associated survival and increased time allowed for oncogenic transformation, incidence rates of HPV-associated malignancy such as anal cancer, penile cancer, and periungual squamous cell carcinoma have increased (71,(231)(232)(233).…”