Reduction in voluntary ethanol intake following repeated oral administration of Jodina rhombifolia lyophilized aqueous extract in male Wistar rats

Jodina rhombifolia leaves lyophilized aqueous extract decreases ethanol intake and preference in adolescent male Wistar rats

“…These findings are in keeping with those previously obtained by our group in adult male Wistar rats (50-60 days old; weight range 190-210 g) (Teves et al, 2015).…”

“…The doses utilized in this experimental procedure were based in previous studies realized by our work group (Teves et al, 2015), which demonstrated that antialcoholic effect of dose 500 mg/kg in adult male Wistar rats not differ of effect of dose 250 mg/kg; whereby, we established the dose 62.5, 125 and 250 mg/kg for experimentation in adolescent rats. Also, this data allows reduction the number of animal used.…”

Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder

“…Repeating administration of Jodina rhombifolia lyophilized extract markedly reduced alcohol voluntary intake in rats in self-administration model of 10 consecutive days, and the treatment was without apparent side-effects [134,135].…”

“…Rats Reduced alcohol intake and blood alcohol levels through curbing alcohol absorption [110] Rats Reduced alcohol intake and delayed acquisition of alcohol-drinking behavior [111] Idn 5082 Rats Delayed acquisition of alcohol drinking behavior, and relapse prevention by suppressing the extra alcohol consumption after deprivation [112,113] salvianolic acid B Rats Attenuation of acute alcohol-induced hepatocyte apoptosis through SIRT1-mediated deacetylation of the p53 pathway [115] Scutellariae Radix Baicalein, baicalin and wogonin Root Rats Attenuated liver fibrosis through liver sinusoidal endothelial cell activation and HSC migration [121] Rhizoma coptidis Berberine Rhizome Rats Reduced alcohol intake and withdrawal induced hyperexcitability through its neuromodulatory action [127,128] Rats Attenuated acute alcohol-induced gastrointestinal mucosa damage through regulation of cytokines [129] Stephania ambigua and Corydalis teranda Levo-tetrahydro-palmatine Rats Reduced alcohol intake through dopamine D2 receptor-mediated PKA signaling in caudate-putamen [130] Strychnos nux-vomica L. Brucine Fruit Rats Decreased alcohol consumption through glycine receptor antagonist [131] Tabernanthe iboga Ibogaine Root Rats Reduced alcohol intake through mediation of glial cell line-derived neurotrophic factor [132] Jodina rhombifolia Unclear Leave Rats Reduced alcohol intake without tolerance and apparent side-effects [134,135] …”

Alcohol intake may impair bone density and new cementum formation after enamel matrix derivative treatment: histometric study in rats

“…However, it is accepted as an adequate method to explore differences in periodontal wound healing within the period used in the present study. The experimental model of alcohol intake was based on studies that showed negative effects of ethanol intake on bone metabolism after 8 wk or shorter periods at 2 , 4 and 6 weeks. In the present study, the average alcohol intake was 6.03 g/kg per d. Li et al .…”