Reduction of adenovirus 36‐induced obesity and inflammation by mulberry extract

Na, Ha-Na; Park, Sooho; Jeon, Hae Myung; Kim, Hyun-Bok; Nam, Jae-Hwan

doi:10.1111/1348-0421.12146

Cited by 16 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ad36‐induced increase in MCP‐1 can be attenuated by exercise intervention, independent of weight loss . Nam et al reported that Mulberry extract reduces inflammatory cytokines MCP‐1, and TNF‐α and M1 macrophage induced by Ad36 …”

Section: Resultsmentioning

confidence: 99%

Twenty‐five years of research about adipogenic adenoviruses: A systematic review

2018

View full text Add to dashboard Cite

Infectious etiology is implicated in chronic diseases such as gastric ulcer or atherosclerosis. However, "infection" is a recent term in the field of obesity. Since the first report in 1982 of obesity due to infection, several microbes have been linked to obesity. Among the adipogenic microbes, avian adenovirus SMAM-1 and human adenovirus Ad36 have been studied most extensively for the past 25 years. Here, we present a systematic review of literature about SMAM-1 and Ad36. Reports from North America, Europe, and Asia reveal strong evidence that Ad36 causes obesity in animals and paradoxically improves glycemic control, and in vitro data provides mechanistic explanation. Considering that experimental Ad36 infection of humans is unlikely, its causative role in human obesity or glycemic control has not been demonstrated unequivocally. Nonetheless, most, but not all, observational studies in children and adults link Ad36 infection to obesity and improvement in glycemic control. The E4orf1 gene of Ad36 was identified as responsible for better glycemic control. Overall, 25 years have considerably advanced knowledge about the role of infection in obesity. Potential translational benefits include the development of vaccines to prevent Ad36-induced obesity and drug development based on the E4orf1 protein to improve glycemic control.

show abstract

Section: Resultsmentioning

confidence: 99%

Twenty‐five years of research about adipogenic adenoviruses: A systematic review

2018

View full text Add to dashboard Cite

show abstract

“…Mulberry leaf has been used to treat fever and inflammation for thousands of years, and its extract also has anti-inflammatory effects. A study showed that MLE inhibited the expression of inflammatory cytokines IL-I, IL-6, and TNF- α [ 107 ] and C-reactive protein (CRP) and MLE reduced the production of iNOS [ 108 ]. The decrease in inflammatory factors is indicative of reduced chronic inflammation and results in the improvement of insulin resistance.…”

Section: Herbal Monomersmentioning

confidence: 99%

New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis

Gao

et al. 2017

Journal of Immunology Research

View full text Add to dashboard Cite

Diabetes, especially type 2, has been rapidly increasing all over the world. Although many drugs have been developed and used to treat diabetes, side effects and long-term efficacy are of great challenge. Therefore, natural health product and dietary supplements have been of increasing interest alternatively. In this regard, Chinese herbs and herbal products have been considered a rich resource of product development. Although increasing evidence has been produced from various scientific studies, the mechanisms of action are lacking. Here, we have proposed that many herbal monomers and formulae improve glucose homeostasis and diabetes through the BMID axis; B represents gut microbiota, M means mucosal immunity, I represents inflammation, and D represents diabetes. Chinese herbs have been traditionally used to treat diabetes, with minimal side and toxic effects. Here, we reviewed monomers such as berberine, ginsenoside, M. charantia extract, and curcumin and herbal formulae such as Gegen Qinlian Decoction, Danggui Liuhuang Decoction, and Huanglian Wendan Decoction. This review was intended to provide new perspectives and strategies for future diabetes research and product.

show abstract

“…Resveratrol and grape extract from Portuguese white‐winemaking by‐products inhibited recombinant adenovirus (Ad5GFP) infection in human 293 cells through inhibition of viral DNA replication . In an adenovirus serotype 36‐induced obesity mouse model, pretreatment with resveratrol‐containing mulberry extract also reduced the expression of viral early gene E1A . Pre‐incubation of feline calicivirus (FCV‐F9), murine norovirus (MNV‐1), or hepatitis A virus (strain HM175) with resveratrol or resveratrol‐containing grape seed extract reduced viral titers .…”

Section: Resveratrol and Virusesmentioning

confidence: 99%

Resveratrol, sirtuins, and viruses

Yang

Zhang

et al. 2015

Reviews in Medical Virology

View full text Add to dashboard Cite

Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. Over the past several decades, a great deal of research has identified diverse biological roles associated with resveratrol, including anti-oxidant, anti-proliferation, anti-inflammation, anti-cancer, anti-fungal, and antiviral activities. Such biological activities of resveratrol are likely mediated through multiple cellular targets or pathways, such as sirtuins, a family of NAD(+)-dependent deacetylases. In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. A working model about the effects of resveratrol on virus infection is proposed to stimulate further researches on this exciting topic.

show abstract

Reduction of adenovirus 36‐induced obesity and inflammation by mulberry extract

Cited by 16 publications

References 14 publications

Twenty‐five years of research about adipogenic adenoviruses: A systematic review

Twenty‐five years of research about adipogenic adenoviruses: A systematic review

New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis

Resveratrol, sirtuins, and viruses

Contact Info

Product

Resources

About