Reduction of bacteriuria and pyuria using cranberry juice

Haverkorn, M. J.

doi:10.1001/jama.272.8.590a

Cited by 44 publications

(17 citation statements)

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“…[10][11][12][13][14][15][16][17] The results from some, but not all, of these trials suggest that cranberry may reduce the incidence of bacteriuria and UTI, particularly in healthy women with acute, uncomplicated cystitis. 6 In 2003, the National Center for Complementary and Alternative Medicine provided a standardized, well-characterized cranberry juice cocktail and matching placebo juice for conduct of studies that evaluated potential health benefits of cranberry products.…”

mentioning

confidence: 99%

Recurrent Urinary Tract Infection and Urinary Escherichia coli in Women Ingesting Cranberry Juice Daily: A Randomized Controlled Trial

Stapleton

Dziura

Hooton

et al. 2012

Mayo Clinic Proceedings

114

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Objective: To compare the time to urinary tract infection (UTI) and the rates of asymptomatic bacteriuria and urinary P-fimbriated Escherichia coli during a 6-month period in women ingesting cranberry vs placebo juice daily. Patients and Methods: Premenopausal women with a history of recent UTI were enrolled from November 16, 2005, through December 31, 2008, at 2 centers and randomized to 1 of 3 arms: 4 oz of cranberry juice daily, 8 oz of cranberry juice daily, or placebo juice. Time to UTI (symptoms plus pyuria) was the main outcome. Asymptomatic bacteriuria, adherence, and adverse effects were assessed at monthly visits. Results: A total of 176 participants were randomized (120 to cranberry juice and 56 to placebo) and followed up for a median of 168 days. The cumulative rate of UTI was 0.29 in the cranberry juice group and 0.37 in the placebo group (Pϭ.82). The adjusted hazard ratio for UTI in the cranberry juice group vs the placebo group was 0.68 (95% confidence interval, 0.33-1.39; Pϭ.29). The proportion of women with P-fimbriated urinary E coli isolates during the intervention phase was 10 of 23 (43.5%) in the cranberry juice group and 8 of 10 (80.0%) in the placebo group (Pϭ.07). The mean dose adherence was 91.8% and 90.3% in the cranberry juice group vs the placebo group. Minor adverse effects were reported by 24.2% of those in the cranberry juice group and 12.5% in the placebo group (Pϭ.07). Conclusion: Cranberry juice did not significantly reduce UTI risk compared with placebo. The potential protective effect we observed is consistent with previous studies and warrants confirmation in larger, well-powered studies of women with recurrent UTI. The concurrent reduction in urinary P-fimbriated E coli strains supports the biological plausibility of cranberry activity.

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confidence: 99%

Recurrent Urinary Tract Infection and Urinary Escherichia coli in Women Ingesting Cranberry Juice Daily: A Randomized Controlled Trial

Stapleton

Dziura

Hooton

et al. 2012

Mayo Clinic Proceedings

114

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“…He showed that the cranberry prophylaxis resulted in a decrease in antibiotic use compared to placebo group and a statistically significant decrease in symptomatic UTI episodes (15). Haverkorn et al also showed that 15 mL cranberry juice twice daily for one month resulted in decreased rates of bacteriuria (16). In a randomized, double-blind, placebo controlled trial including 153 elderly women revealed that usage of cranberry has resulted in significantly less bacteriuria with pyuria (17).…”

Section: Discussionmentioning

confidence: 60%

The role of an herbal agent in treatment for Escherichia coli induced bacterial cyctitis in rats

Tüken

Temiz

Yürük

et al. 2017

Arch Ital Urol Androl

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Objectives: The aim of this study is to evaluate the effects of the herbal agent in the prevention and treatment of bacterial cystitis in a rat model. Material and Methods: A total of twenty-eight male SpragueDawley rats were divided into four groups. Group-1 constituted the control group (operated and normal saline injected into the bladder, received only drinking water for 7 days); Group-2 constituted the no-treatment group (operated, E.coli J96 strain injected into the bladder, received only drinking water for 7 days); Group-3 constituted the short-term treatment (operated, E.coli J96 strain injected into the bladder, received the herbal agent added into drinking water for 7 days) and Group-4 constituted the long-term treatment (operated, E. coli J96 strain injected into the bladder, received herbal agent added into drinking water for 14 days). At the end of the pre-defined treatment periods of duration, the rats were sacrificed, urine samples collected from the bladder for culture and bladders were harvested for histopathological evaluation. Urine culture results and histopathological findings were comparatively evaluated between the groups. Results: Urine cultures were positive for implanted E. coli strains in 0%, 85.7%, 42.8% and 0% of rats in Group 1, Group 2, Group 3 and Group 4, respectively (p = 0.001). Although histopathological evaluation revealed increased vascular dilation in the bladder specimens obtained from Group 2 and Group 3 (p = 0.028) no significant difference was noticed in level of inflammation (p = 0.610), edema (p = 0.754) and thickness of uroepithelium (p = 0.138). Conclusion: While long term (14 days) treatment with an herbal agent added into the drinking water resulted in complete clearance of urine from E. coli; shorter application of the agent revealed partial clearance. Further clinical studies are needed to support our results.KEY WORDS: Antibiotics; Bacterial cystitis; Herbal agent. use, related antimicrobial resistance and the spread of bacterial resistant strains make the problem more serious than ever. Like other infectious diseases, the early and proper treatment of cystitis decreases the incidence of disease related morbidity and this situation necessitates the initiation of an empirical antimicrobial treatment in the majority of cases (2). On the other hand, with this approach, the antimicrobial resistance patterns of the hospital and the country are generally ignored by the responsible physicians. Administration of an inappropriate empirical antimicrobial therapy may eventually result in the accelerated rates of antimicrobial resistance (3). Moreover, these agents are also being used for the antimicrobial prophylaxis in the prevention of urinary tract infections particularly in patients with anatomical abnormalities or increased tendency for serious urinary tract infections. However, the long term prophylactic use of antimicrobial agents has the potential risk of not only the drug resistance but also the development of drug related adverse events. Taking all these facts a...

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“…Även dos och metod för administration som juice eller tabletter var oklar. Flera studier hade ett stort bortfall (12)(13)(14)(15) vilket tolkades bero på att tranbärsjuicekonsumtion är svår att tolerera under längre perioder p g a av den beska smaken. Cochranereview:n (5) gav inget entydigt svar.…”

Section: Tidigare Forskningunclassified

“…Detta kan innebära stora skillnader hos såväl vårdtagarnas hälsostatus som utbildningsgrad hos personalen vilket kan ha påverkat resultatet, och gör att studien bedömts ha medelhög vetenskaplig kvalitet. I Cochranereview:n av Jepson & Craig (5) återfinns tre studier (13,15,17) som innefattar äldre människor och inte heller i dessa studier kan det påvisas att tranbär ger något preventivt skydd mot symptomatisk UVI. Det finns således ett otillräckligt vetenskapligt underlag effekten av tranbär och förekomst av UVI hos äldre människor.…”

Section: Diskussionunclassified

Tranbär, ett alternativ till antibiotika? En litteraturstudie om tranbär som prevention mot urinvägsinfektion

Windefors¹,

Seibold²,

Garmy

2010

Nordic Journal of Nursing Research

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Reduction of bacteriuria and pyuria using cranberry juice

Cited by 44 publications

References 0 publications

Recurrent Urinary Tract Infection and Urinary Escherichia coli in Women Ingesting Cranberry Juice Daily: A Randomized Controlled Trial

Recurrent Urinary Tract Infection and Urinary Escherichia coli in Women Ingesting Cranberry Juice Daily: A Randomized Controlled Trial

The role of an herbal agent in treatment for Escherichia coli induced bacterial cyctitis in rats

Tranbär, ett alternativ till antibiotika? En litteraturstudie om tranbär som prevention mot urinvägsinfektion

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