Reduction of blood pressure by aronia berries through inhibition of angiotensin-converting enzyme activity in the spontaneously hypertensive rat kidney

Yamane, Toshimi; Kozuka, Miyuki; Imai, Momoko; Yamamoto, Yoshio; Ohkubo, Iwao; Sakamoto, Tatsuji; Nakagaki, Takenori; Nakano, Yoshihisa

doi:10.31989/ffhd.v7i4.354

Cited by 12 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in line with the data that both Aronia berries and Aronia polyphenol extracts reduce quite effectively both SBP and DBP in spontaneously hypertensive rats [19]. The proposed mechanism might be through inhibition of the kidney renin-angiotensin system [20]. Others also found that A. melanocarpa extract decreases blood pressure in experimental model of hypertension [21,22].…”

Section: Discussionsupporting

confidence: 83%

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Jakovljević

Milić²,

Bradić

et al. 2018

IJMS

View full text Add to dashboard Cite

The aim of our study was to examine the effects of different dietary strategies, high-fat (HFd) or standard diet (Sd) alone or in combination with standardized oral supplementation (0.45 mL/kg/day) of Aronia melanocarpa extract (SAE) in rats with metabolic syndrome (MetS). SAE is an official product of pharmaceutical company Pharmanova (Belgrade, Serbia); however, the procedure for extraction was done by EU-Chem company (Belgrade, Serbia). Rats were divided randomly into six groups: control with Sd, control with Sd and SAE, MetS with HFd, MetS with HFd and SAE, MetS with Sd and MetS with Sd and SAE during 4 weeks. At the end of the 4-week protocol, cardiac function and liver morphology were assessed, while in the blood samples glucose, insulin, iron levels and systemic redox state were determined. Our results demonstrated that SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Moreover, SAE improved glucose tolerance, attenuated pathological liver alterations and oxidative stress present in MetS. Obtained beneficial effects of SAE were more prominent in combination with changing dietary habits. Promising potential of SAE supplementation alone or in combination with different dietary protocols in triggering cardioprotection should be further examined in future.

show abstract

Section: Discussionsupporting

confidence: 83%

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Jakovljević

Milić²,

Bradić

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…In studies conducted in spontaneously hypertensive rats a diet with 10% of lyophilised chokeberry reduced their blood pressure after three days [ 103 ] ( Table 2 ). However, a statistically significant reduction of the SBP occurred after 28 days.…”

Section: Influence Of Chokeberry On Hypertensionmentioning

confidence: 99%

The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases

Kasprzak-Drozd

Oniszczuk

Soja

et al. 2021

IJMS

View full text Add to dashboard Cite

Epidemiological studies have emphasized the association between a diet rich in fruits and vegetables and a lower frequency of occurrence of inflammatory-related disorders. Black chokeberry (Aronia melanocarpa L.) is a valuable source of biologically active compounds that have been widely investigated for their role in health promotion and cardiovascular disease prevention. Many in vitro and in vivo studies have demonstrated that consumption of these fruits is associated with significant improvements in hypertension, LDL oxidation, lipid peroxidation, total plasma antioxidant capacity and dyslipidemia. The mechanisms for these beneficial effects include upregulation of endothelial nitric oxide synthase, decreased oxidative stress, and inhibition of inflammatory gene expression. Collected findings support the recommendation of such berries as an essential fruit group in a heart-healthy diet. The aim of this review was to summarize the reports on the impact of black chokeberry fruits and extracts against several cardiovascular diseases, e.g., hyperlipidemia, hypercholesterolemia, hypertension, as well as to provide an analysis of the antioxidant and anti-inflammatory effect of these fruits in the abovementioned disorders.

show abstract

“…Yamane et al (2017) administered a diet containing 10% freeze‐dried Aronia berries to spontaneously hypertensive rats for 28 days and found that blood pressure decreased in rats, as well as catalytic activity of ACE. They pointed out that the presence of cyanidin, cyanidin 3‐O‐glycoside, and quercetin 3‐O‐glycoside present in Aronia berries were effective in this regard.…”

Section: The Role Of Berries In Modulation Of Hypertensionmentioning

confidence: 99%

Insights to potential antihypertensive activity of berry fruits

Yousefi

Shadnoush

Khorshidian

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

Hypertension is one of the main risk factors for cardiovascular disease and causes widespread morbidity and mortality worldwide. Although several antihypertensive drugs have been proposed for management of high blood pressure, changing lifestyle, including diet, has attracted interest recently. In this sense, consumption of fruits and vegetables, which are rich in vitamins, minerals, and phytochemicals, has been assigned as an efficient therapeutics. Berry fruits contain various bioactive compounds with potential health implications such as antioxidant, antimicrobial, anticancer, and anti‐inflammatory properties. The main mechanisms responsible for antihypertensive activity mainly arise from the activity of flavonoids, minerals, and vitamins, as well as fibers. The objective of this review is to provide a summary of studies regarding the effect of berry fruits on the hypertensive animals and humans. The mechanisms involved in reducing blood pressure by each group of compounds have been highlighted. It can be concluded that berries' bioactive compounds are efficient in mitigation of hypertension through improvement of vascular function, angiotensin‐converting enzyme's (ACE) inhibitory activity, increasing endothelial nitric oxide synthase (eNOS) activity, and nitric oxide (NO) production, besides anti‐oxidative and anti‐inflammatory activities. These fruits can be considered as potential sources of invaluable compounds for development of antihypertensive foods and pharmaceuticals.

show abstract

Reduction of blood pressure by aronia berries through inhibition of angiotensin-converting enzyme activity in the spontaneously hypertensive rat kidney

Cited by 12 publications

References 0 publications

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases

Insights to potential antihypertensive activity of berry fruits

Contact Info

Product

Resources

About