Reduction of cardiovascular risk in subjects with high lipoprotein (a) levels

Malaguarnera, Giulia; Latteri, Saverio; Catania, Vito Emanuele; Malaguarnera, Michele

doi:10.21037/jtd.2017.08.67

Cited by 7 publications

(5 citation statements)

References 46 publications

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“…The pathogenesis of MHE has been associated with impairment in cerebral energy metabolism with alteration in glucose utilization, glycolysis, and mitochondrial dysfunction. It is thought that impaired mitochondrial function and the down-regulation of the expression of key anti-oxidation enxzymes contribute to an increase in oxidative damage to membrane lipids [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol in Patients with Minimal Hepatic Encephalopathy

et al. 2018

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Background: Minimal Hepatic Encephalopathy (MHE) is characterized by an impairment of social interaction, emotional behavior, sleep disorders, physical and mental symptoms, and diminished Quality of Life (QoL). The aim of our study is evaluating the potential liver health promoting a perspective of Resveratrol (RV) activities and evaluate whether RV treatment may improve health related quality of life (HRQL) and reduce depression and anxiety in patients with MHE. Methods: We evaluated depression using the Beck Depression Inventory test, anxiety with State-trait anxiety inventory test, quality of life through SF-36 test, and ammonia serum levels in 70 MHE patients that were randomized into two groups. Results: In the comparison between RV group and placebo group we observed a decrease in Back Depression Inventory (BDI) (p < 0.001), in State-trait anxiety inventory (STAI) (p < 0.001), and improve in physical function (p < 0.001), in role physical (p < 0.05), in body pain (p < 0.05), in general health (p < 0.001), in vitality (p < 0.05), and in social function (p < 0.001). Conclusions: Resveratrol showed efficacy in the treatment of depression, anxiety, and ammonia serum levels, and improved the quality of life Of MHE patients.

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Section: Discussionmentioning

confidence: 99%

Resveratrol in Patients with Minimal Hepatic Encephalopathy

et al. 2018

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“…Having a cholesterol molecule in its structure increases atherogenesis [31]. Since it carries oxidized phospholipids, which are more atherogenic, it has been shown to be pro-inflammatory [33,34,35,36].…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification

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Özçeli̇k

Yıldız

et al. 2019

JCDD

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Calcific aortic valve disease (CAVD) is a multifactorial condition. Both environmental andgenetic factors play an important role in its etiology. CAVD exhibits a broad spectrum, varying frommild valve thickening to severe valve calcification and stenosis. Progression of the disease consistsof chronic inflammation, lipoprotein deposition, and active leaflet calcification. It is a process similarto coronary artery disease. In this study, we investigated Lp(a) levels and gene polymorphismsassociated with calcific aortic stenosis from blood samples after echocardiography in the evaluationof 75 patients diagnosed with CAVD and 77 controls. Blood tests were run in our laboratory to ruleout certain risk factors before echocardiography examination. A significant association amongsmoking, elevated LDL level and creatinine, low albumin levels, Lp(a) level, rs10455872, andrs3798220 polymorphisms may be considered genetic risk factors for the development of calcificaortic stenosis.

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“…In addition, Ca 19-9 can be used to screen the disease process in patients with gastrointestinal tract cancers who had no elevation of CEA levels. Ca 19-9 can be used to diagnose pancreatic, gastric, and colorectal cancer [ 43 , 44 , 45 , 46 ]. Another study has been conducted on four immunochemistry markers simultaneously, including epithelial membrane antigen (EMA), cluster of differentiation 10 (CD10), B-cell lymphoma 2 (Bcl-2), and CEA, to distinguish between BCC and SCC.…”

Section: Discussionmentioning

confidence: 99%

Carcinoembryonic Antigen Serum Levels in Nonmelanoma Skin Cancer

et al. 2018

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Background: Carcinoembryonic antigen (CEA) is a glycoprotein, which is present in the foetal colon, some benign conditions and different malignancies, particularly in colon adenocarcinoma. We focused this study on non-melanoma skin cancer (NMSC). NMSC is a common malignancy and it is an important source of morbidity and death in the world. In this study we evaluated whether CEA level increases in NMSC. Patients and Methods: A total of 566 patients with non-melanoma skin cancer (NMSC) were enrolled; 286 patients with NMSC showed CEA levels above normal values, and 280 showed CEA levels below normal values. Patients with high levels of CEA underwent abdominal ultrasound, gastro endoscopy, colonoscopy, and abdominal CT scans. Results: We studied 566 patients, 286 were positive to CEA and 280 were negative. Of the 286 patients positive to CEA, 132 had basal cell carcinoma (64 patients had an associated cancer) and 154 had squamous cell carcinoma (75 patients were affected by cancer). Of the 280 patients negative to CEA, 130 had basal cell carcinoma (12 were associated with cancer), and 150 had squamous cell carcinoma (18 were associated with cancer). The mean age of the 566 case control subjects were 65–81 years. Of the 10 subjects that were the positive control for CEA, two had cancer. Of the 556 subjects that were the negative control for CEA, three had cancer. Conclusions: In patients that present high serum levels of CEA, we give attention to adenocarcinoma tumour first. The pattern of association may be attributable to bias because the group with NMSC were frequently evaluated than those with no history of NMSC. Our results showed that out of 286 patients that were CEA-positive, 139 had cancer, and of the 280 that were CEA-negative, 30 had cancer. Therefore, 20% of patients do not follow the trend. Other markers should be investigated.

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Reduction of cardiovascular risk in subjects with high lipoprotein (a) levels

Cited by 7 publications

References 46 publications

Resveratrol in Patients with Minimal Hepatic Encephalopathy

Resveratrol in Patients with Minimal Hepatic Encephalopathy

Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification

Carcinoembryonic Antigen Serum Levels in Nonmelanoma Skin Cancer

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