Reduction of Cisplatin Ototoxicity by Fosfomycin in Animal Model

Ohtani, Iwao; Ohtsuki, Kohsei; Aikawa, Tohru; Anzai, Tomohiro; O‐Uchi, Jin; Saito, Takehisa

doi:10.1159/000275777

Cited by 20 publications

(11 citation statements)

References 7 publications

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“…Higher doses of cisplatin in the rat have been associated with significant mortality. [24][25][26] Three milliliters of sterile 0.9 percent saline were administered immediately after each cisplatin injection to counteract the nephrotoxicity of the drug. 22,24 Rats received rat chow and water ad libitum and were housed four to a plastic cage that contained wood chips.…”

Section: Methodsmentioning

confidence: 99%

Utility of Decompressive Surgery in the Prophylaxis and Treatment of Cisplatin Neuropathy in Adult Rats

Tassler¹,

Dellon²,

Lesser³

et al. 2000

J reconstr Microsurg

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Cisplatin produces a dose-dependent and dose-limiting peripheral neuropathy in patients. This study tested the hypothesis that this clinical neuropathy results from the chronic compression of peripheral nerves rendered susceptible to injury because of cisplatin-induced microtubular dysfunction. A quantitative model of cisplatin neurotoxicity was developed by administering cisplatin to rats and measuring the neuropathy by hindlimb walking track assay. The study aims were: (1) to characterize neuropathy induced by cisplatin in the adult rat; (2) to evaluate the role of decompressive surgery in the prevention of cisplatin neuropathy; and (3) to determine whether decompressive surgery was an effective treatment for established neuropathy. The assay demonstrated an increased print length in animals after 8 weeks of cisplatin (p < 0.01). This neuropathy progressed for 6 weeks after cisplatin was stopped, and reversed slowly over 3 months. These abnormalities were prevented by early tarsal tunnel decompression. Decompressive surgery was also beneficial, if performed early in the course of the neuropathy; abnormalities reversed in 5 weeks and remained normal for the remainder of the study. Control animals had progressive abnormalities which slowly resolved over a period of 18 weeks after discontinuing cisplatin. However, decompressive surgery performed after the neuropathy was established did not alter the neuropathic walking-track pattern. These studies provide insight into the etiology and possible therapeutic approaches to cisplatin neuropathy. Although further studies are required, they suggest that, in selected patients, decompressive surgery may have a role in the prevention or early treatment of cisplatin-induced neuropathy. Patients with underlying clinical or subclinical compressive neuropathies could be at high risk for the development of cisplatin neuropathy, and quantitative monitoring of neuropathies may be useful.

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Section: Methodsmentioning

confidence: 99%

Utility of Decompressive Surgery in the Prophylaxis and Treatment of Cisplatin Neuropathy in Adult Rats

Tassler¹,

Dellon²,

Lesser³

et al. 2000

J reconstr Microsurg

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“…There are also many reports of the protective action of fosfomycin against drug-induced nephrotoxicity (Inouye and others 1982, Fujita and others 1983, Ohtani and others 1984, Yogi and others 1989, Shibuya and others 1990, Wada and others 1995, Gobernado 2003). However, there have been no reports of nephrotoxicity associated with fosfomycin administration in human beings or animals.…”

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confidence: 99%

Acute renal insufficiency in cats after fosfomycin administration

Fukata

Imai²,

Shibata³

2008

Veterinary Record

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“…[1][2][3][4][5][6] However, it has not been studied immuno-electron microscopically. 19 7 -13 Studies of keratin localization in the determined.…”

mentioning

confidence: 99%

Immuno-Electron Microscopic Study of Keratin Distribution in the Cochlea Using Monoclonal Antibody

Shi¹,

Kobari²,

Ohtani³

et al. 1990

Ann Otol Rhinol Laryngol

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Keratin distribution in the cochlea has been studied immuno-electron microscopically by both pre-embedding and postembedding methods. Keratin immunoreactivity in the guinea pig cochlea was clearly demonstrated in Hensen's cells, the reticular lamina surrounding both outer and inner hair cells, outer and inner pillar cells, Claudius' cells, inner and external sulcus cells, interdental cells of the spiral limbus, Reissner's membrane, border cells, inner phalangeal cells, Deiters' cells, and spiral prominence cells. Keratin expression at the ultrastructural level showed a nonfilamentous keratin system in the cytoplasm of cochlear supporting cells.

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Reduction of Cisplatin Ototoxicity by Fosfomycin in Animal Model

Cited by 20 publications

References 7 publications

Utility of Decompressive Surgery in the Prophylaxis and Treatment of Cisplatin Neuropathy in Adult Rats

Utility of Decompressive Surgery in the Prophylaxis and Treatment of Cisplatin Neuropathy in Adult Rats

Acute renal insufficiency in cats after fosfomycin administration

Immuno-Electron Microscopic Study of Keratin Distribution in the Cochlea Using Monoclonal Antibody

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