Reduction of Dental Plaque Deposition in Humans by Oolong Tea Extract

Ooshima, Takashi; Minami, Takahiro; W, Aono; Tamura, Yukie; Hamada, Shigeyuki

doi:10.1159/000261636

Cited by 81 publications

(50 citation statements)

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“…Animal studies have demonstrated that various tea extracts prevented or reduced caries formation (46,48,49,55). Clinical trials have also shown that drinking tea (without added sugar) is associated with lower caries levels in humans (30,47,50). Our previous study in adult humans found that rinsing with black tea extract resulted in a significantly less-pronounced plaque pH fall and a lower plaque index than the water-rinse group (70).…”

mentioning

confidence: 99%

The Tea Catechin Epigallocatechin Gallate Suppresses Cariogenic Virulence Factors of Streptococcus mutans

Zhou

2011

Antimicrob Agents Chemother

272

227

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Streptococcus mutans, the primary etiologic agent of dental caries, possesses a series of virulence factors associated with its cariogenicity. Alternatives to traditional antimicrobial treatment, agents selectively inhibiting the virulence factors without necessarily suppressing the resident oral species, are promising. The anticariogenic properties of tea have been suggested in experimental animals and humans. Tea polyphenols, especially epigallocatechin gallate (EGCg), have been shown to inhibit the growth and glucosyltransferases activity of S. mutans. However, their effects on biofilm and cariogenic virulence factors of oral streptococci other than glucosyltransferases have not been well documented. In this study, we investigated the biological effect of EGCg on the virulence factors of S. mutans associated with its acidogenicity and acidurity. The antimicrobial effects of EGCg on S. mutans biofilm grown in chemically defined medium were also examined. EGCg inhibited growth of S. mutans planktonic cells at an MIC of 31.25 g/ml and a minimal bactericidal concentration (MBC) of 62.5 g/ml. EGCg also inhibited S. mutans biofilm formation at 15.6 g/ml (minimum concentration that showed at least 90% inhibition of biofilm formation) and reduced viability of the preformed biofilm at 625 g/ml (sessile MIC 80 ). EGCg at sub-MIC levels inhibited acidogenicity and acidurity of S. mutans cells. Analysis of the data obtained from real-time PCR showed that EGCg significantly suppressed the ldh, eno, atpD, and aguD genes of S. mutans UA159. Inhibition of the enzymatic activity of F 1 F o -ATPase and lactate dehydrogenase was also noted (50% inhibitory concentration between 15.6 and 31.25 g/ml). These findings suggest that EGCg is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity.

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confidence: 99%

The Tea Catechin Epigallocatechin Gallate Suppresses Cariogenic Virulence Factors of Streptococcus mutans

Zhou

2011

Antimicrob Agents Chemother

272

227

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“…Compounds present in both green and oolong teas have been studied on dental caries in a simple form and individually (6,7). Animals and humans given tea compounds in their drinking water develop fewer dental caries and less plaque formation than those drinking plain water (8)(9)(10)(11). Drinking green tea may also help prevent sore throats and colds, since it helps fight the bacteria harboring in the throat (12), another reason that encouraged us to work on Iranian green tea other than its healing effect on burn and wound, which was also in the area of our studies (13,14), was a traditional belief for its masking the bad breath.…”

Section: Moghbel a Et Al Evaluation The Effect Of Green Tea Extract mentioning

confidence: 99%

Evaluation of the Effect of Green Tea Extract on Mouth Bacterial Activity in the Presence of Propylene Glycol

Moghbel

Farjzadeh

Aghel

et al. 2012

Jundishapur J Nat Pharm Prod

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Background: Compounds present in green tea have proved to inhibit the growth and activity of bacteria associated with infections. Objectives: To assess the effects of green tea leaves extract in presence of propylene glycol on the aerobic mouth bacteria load. Materials and Methods: Saliva of 25 volunteer girl students aging 20-25 years were selected and evaluated by a mouthwash sample containing 1% tannin, as the most effective antibacterial complex in green tea. Comparative studies were also conducted between green tea mouthwashes containing 1% tannin and a similar sample with 10% propylene glycol added during extraction. This comparison was applied for a chlorhexidine 0.2% sample as a chemical mouthwash brand, too. Results: There was a meaningful difference between the green tea mouthwashes containing 10% propylene glycol and the simple green tea extract (P < 0.05). Significant difference was also seen between the herbal and chemical mouthwashes (P < 0.05). The extract 1% tannin containing 10% propylene glycol reduced the aerobic mouth bacterial load of the student salvia about 64 percent. The pH monotonousness in different days and temperatures approved the stability of tannin in liquid water medium. Conclusions: Using green tea extract as a herbal mouthwash is safe and harmless specially for children and pregnant women. This result led us to suppose that green tea may prevent plaque formation on teeth, coming over halitosis due to mouth infection, too. These effects need to be approved in an in vivo trial as a second study.

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“…S. mutans 로부터의 glucosyltransferase(Gtase)에 의해 합성되는 불용성 glucan 또한 치석을 형 성하여 산을 축적시킴으로서 치아 에나멜층의 국소적 탈미네랄 화를 야기 시킨다 (9 2) Glucosyltransferase(GTase)의 활성저해 S. mutans 균이 생성하는 GTase가 sucrose를 이용하여 점착성 을 지니며 불용성인 glucan을 합성, dental plaque를 형성하므로, 앞선 실험결과 S. mutans 균에 대해 항균활성이 높은 것으로 나 타난 표고버섯, 영지버섯 및 만가닥버섯만을 대상으로 이들 추출 물의 GTase 활성 저해 효과를 조사해 보았다 (Fig. 1) …”

Section: 서 론unclassified

Anti-cariogenic Activities of Mushroom Extracted with Various Solvent Systems

Park¹,

Lee²,

Choi³

2011

Korean Journal of Food Science and Technology

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Various mushroom extracts were examined for their anti-Streptococcus mutans and anti-glucosyltransferase (GTase) activities. Mushrooms were extracted with chloroform, methanol, acetone, ethyl acetate, and distilled water. The chloroform, methanol, and ethyl acetate extracts showed higher antimicrobial activity than that of the others. The inhibitory effects of the chloroform, methanol, and ethyl acetate extracts of Lyopyllum ulmarium, which have high anti-microbial and GTase activities, on the growth of S. mutans were examined and the optimal ratio of solvents was also evaluated to investigate the influence of solvents using a simplex centroid design. The anti-cariogenic effects of the L. ulmarium extract on S. mutans was influenced by the solvent, and the optimum anti-cariogenic activity of the extract was obtained with the ratio of chloroform:methanol:ethyl acetate=1:1:1 (v/v/v). These results suggest that solvent selection is an important factor to extract anti-cariogenic materials effectively from mushrooms. 재료 및 방법버섯 및 버섯추출물 제조 실험에 사용된 버섯은 국내 자생 버섯으로 양송이(Agaricus bisporus), 팽이(Flamm velutipes), 영지(Ganoderma lucidum), 노루 궁데이(Hericium erinaceum), 만가닥(Lyopyllum ulmarium), 검은비

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Reduction of Dental Plaque Deposition in Humans by Oolong Tea Extract

Cited by 81 publications

References 5 publications

The Tea Catechin Epigallocatechin Gallate Suppresses Cariogenic Virulence Factors of Streptococcus mutans

The Tea Catechin Epigallocatechin Gallate Suppresses Cariogenic Virulence Factors of Streptococcus mutans

Evaluation of the Effect of Green Tea Extract on Mouth Bacterial Activity in the Presence of Propylene Glycol

Anti-cariogenic Activities of Mushroom Extracted with Various Solvent Systems

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