Reduction of disinfectant bactericidal activities in clinically isolated Acinetobacter species in the presence of organic material

Kawamura-Sato, Kumiko; Wachino, Jun-ichi; Kondo, Takaaki; Ito, Hideo; Arakawa, Yoshichika

doi:10.1093/jac/dkm498

Cited by 69 publications

(40 citation statements)

References 22 publications

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“…The concentrations detected in this study were lower than those. Additionally, the effect of disinfectants on bacteria was considerably reduced in the presence of organic matter (22), suggesting the actual active concentration in the environment to be lower than the analysis suggests. Most sampling sites in this study showed quite high organic matter concentrations, 3.81-235 mg-C L −1 (Table S1).…”

Section: Discussionmentioning

confidence: 82%

Fluoroquinolone (FQ) Contamination Does Not Correlate with Occurrence of FQ-Resistant Bacteria in Aquatic Environments of Vietnam and Thailand

et al. 2011

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Fluoroquinolone antibiotics (FQs) have been used worldwide for chemotherapy, animal husbandry, and aquaculture, and the occurrence of FQ-resistant (FQs r ) bacteria in natural environments has been reported. Plasmid-mediated transferable quinolone resistance (PMQR) genes are suspected to originate from the chromosomes of water-dwelling bacteria. However, the occurrence of and the potential reservoir of FQs r bacteria and PMQR genes in aquatic environments have not been elucidated. In this study, we detected FQs r bacteria and PMQR genes in aquatic environments in Thailand and Vietnam, and measured FQ contamination. Levels of contamination were greater Thailand (avg. 5130, max 46100 ng L −1 ) than in Vietnam (avg. 235, max 1130 ng L −1 ); however, the occurrence of FQs r bacteria was higher in Vietnam (~15%) than in Thailand (~7.0%), suggesting that contamination by FQs is not directly linked to the development of FQs r bacteria. Diverse taxonomic groups of FQs r -bacteria were identified, and one of the PMQR genes, qnrB, was detected from bacteria of environmental origin, not enteric bacteria. This suggests that the environmental bacteria are a potential reservoir of antibiotic resistance determinants even at un-contaminated sites.

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Section: Discussionmentioning

confidence: 82%

Fluoroquinolone (FQ) Contamination Does Not Correlate with Occurrence of FQ-Resistant Bacteria in Aquatic Environments of Vietnam and Thailand

et al. 2011

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“…Of particular concern is the emergence of A. baumannii strains resistant to all commonly used antibiotics, including colistin (13,30), polymyxin B (27), or tigecycline (25). Furthermore, A. baumannii displays an extraordinary tolerance to desiccation and disinfectants, which contributes to its long-term persistence in the hospital environment and the occurrence of outbreaks of infection (1,5,18,21).…”

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confidence: 99%

Evaluation of the Trimeric Autotransporter Ata as a Vaccine Candidate against Acinetobacter baumannii Infections

et al. 2012

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Acinetobacter baumannii is a multidrug-resistant (MDR) nosocomial pathogen for which immunotherapeutic alternatives are needed. We previously identified a surface autotransporter of A. baumannii, Ata, that bound to various extracellular matrix/basal membrane proteins and was required for full virulence, biofilm formation, and the adhesion of A. baumannii to collagen type IV. We show here that Ata binding to collagen type IV was inhibited by antibodies to Ata. In addition, in the presence of complement and polymorphonuclear cells (PMNs), antibodies to Ata were highly opsonic against A. baumannii ATCC 17978 and showed low to moderate killing activity against four heterologous A. baumannii strains, whereas in the absence of PMNs, antibody to Ata efficiently promoted complement-dependent bactericidal killing of all of the tested A. baumannii isolates. Using a pneumonia model of infection in both immunocompetent and immunocompromised mice, we found that, compared to normal rabbit sera, antisera to Ata significantly reduced the levels of A. baumannii ATCC 17978 and two MDR strains in the lungs of infected mice. The ability of Ata to engender anti-adhesive, bactericidal, opsonophagocytic, and protective antibodies validates its potential use as an antigenic target against MDR A. baumannii infections.

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“…4 The bactericidal effects of agents against A. baumannii are considerably reduced in the presence of organic material. 5 These principles of decreased effectiveness if contact times are short or organic material is present may have contributed to the lack of effect of our prior cleaning regimen. Alternatively, the oxidizing disinfectant that we used may have had enhanced killing activity against A. baumannii.…”

Section: Discussionmentioning

confidence: 99%

Control of an Outbreak of Carbapenem-ResistantAcinetobacter baumanniiin Australia after Introduction of Environmental Cleaning with a Commercial Oxidizing Disinfectant

Doidge¹,

Allworth²,

Woods³

et al. 2010

Infect. Control Hosp. Epidemiol.

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Reduction of disinfectant bactericidal activities in clinically isolated Acinetobacter species in the presence of organic material

Cited by 69 publications

References 22 publications

Fluoroquinolone (FQ) Contamination Does Not Correlate with Occurrence of FQ-Resistant Bacteria in Aquatic Environments of Vietnam and Thailand

Fluoroquinolone (FQ) Contamination Does Not Correlate with Occurrence of FQ-Resistant Bacteria in Aquatic Environments of Vietnam and Thailand

Evaluation of the Trimeric Autotransporter Ata as a Vaccine Candidate against Acinetobacter baumannii Infections

Control of an Outbreak of Carbapenem-ResistantAcinetobacter baumanniiin Australia after Introduction of Environmental Cleaning with a Commercial Oxidizing Disinfectant

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