Reduction of Fertility in Female Mice Iso-Immunized With a Sub-Cellular Sperm Fraction

Bell, Eric B.; McLaren, Anne

doi:10.1530/jrf.0.0220345

Cited by 46 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the number of eggs fertilized than McLaren and Bell found on the number of liveborn offspring (McLaren, 1964(McLaren, , 1966Bell, 1969;Bell & McLaren, 1970). However, none of the female mice in Edwards experiments received fewer than 30 \ m=x\106 spermatozoa.…”

mentioning

confidence: 82%

“…All of the work by McLaren and Bell (McLaren, 1964, 1966;Bell, 1969;Bell & McLaren, 1970) (McLaren, 1964(McLaren, , 1966Bell, 1969;Bell & McLaren, 1970). However, none of the female mice in Edwards experiments received fewer than 30 \ m=x\106 spermatozoa.…”

mentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

See 2 more Smart Citations

Decreased Fertility in Female Mice Immunized With a Carrier Followed by Small Numbers of Spermatozoa

Erickson¹

1973

Reproduction

View full text Add to dashboard Cite

It has been conclusively shown that immunization of female mice with spermatozoa can significantly decrease their fertility (McLaren, 1964(McLaren, , 1966Edwards, 1964;Bell, 1969;Bell & McLaren, 1970). All of the work by McLaren and Bell (McLaren, 1964, 1966;Bell, 1969;Bell & McLaren, 1970) (McLaren, 1964(McLaren, , 1966Bell, 1969;Bell & McLaren, 1970). However, none of the female mice in Edwards experiments received fewer than 30 \ m=x\106 spermatozoa. This paper reports significant decreases in the fertility of female mice immunized with 15 IO6 spermatozoa by utilization of the carrier effect ('coopera tivi ty').Random-bred Swiss Webster mice were mated before sensitization and only fertile pairs were used in the experiment. A patch, 5 to 6 cm2, was shaved on the belly of the females and 0-05 ml of 0-5% l-fluoro-2-4-dinitrobenzene (FDNB) in a mixture of acetone and olive oil was applied three times at 10-day intervals by painting on the skin. This quantity and dosage schedule had been found to give maximal delayed hypersensitivity to dinitrophenol (DNP) in the CBA strain of mice (Taylor & Iverson, 1971

show abstract

mentioning

confidence: 82%

mentioning

confidence: 99%

See 1 more Smart Citation

Decreased Fertility in Female Mice Immunized With a Carrier Followed by Small Numbers of Spermatozoa

Erickson¹

1973

Reproduction

View full text Add to dashboard Cite

show abstract

“…Injection of females with homologous spermatozoa or testis homogenates reduces fertility in rabbits (Behrman &Nakayama, 1965;Menge, 1968;Bell, 1969a), guinea-pigs (Isojima, Graham & Graham, 1959 ; Katsh, 1959 ; Behrman, Otani, Porter & Nakayama, 1963) and mice (Edwards, 1964 ;McLaren, 1964McLaren, ,1966Bell, 1969b;Bell & McLaren, 1970;Erickson, 1973). In contrast to the numerous studies of the antigenic properties of testis and spermatozoa, relatively few studies have been made on the antigenic composition of ovaries and eggs (Shivers, 1974).…”

Section: Introductionmentioning

confidence: 99%

Reproduction in rats and mice isoimmunized with homogenates of ovary or testis with epididymis, or sperm suspensions

Tsunoda¹,

Chang²

1976

Reproduction

View full text Add to dashboard Cite

“…

…”

mentioning

confidence: 99%

An Antiglobulin Test for the Detection of Surface Antigens of Mouse Spermatozoa

Erickson¹

1972

Reproduction

View full text Add to dashboard Cite

(Bell & McLaren, 1970). Serum from mice immunized with whole spermatozoa (Group Sp) or the supernatant fraction of disrupted spermatozoa (Group Sup+ Sup -A) were pooled and designated Pool S and T-34, respectively. A rabbit anti-mouse-y-globulin was prepared by immunization of rabbits with the purified y-globulin from non-immune CBA mice prepared by ammonium sulphate fractionation and DEAE cellulose ion-exchange chromatography (Fahey, 1967). The resultant rabbit anti-mouse-y-globulin serum was carefully purified before labelling by an immunoadsorbent column. The easily purified mouse y-globulin (IgG 2a) myeloma protein, MOPC 5563, was covalently linked to cyanogen-bromide-activated Sepharose (Axen, Porath & Ernback, 1967). The rabbit anti-mouse-y-globulin serum was passed over a column of the immunoadsorbent and non-bound protein removed by continued washing with borate buffer. The specific rabbit anti-mouse-y-globulin was then eluted with 0-1 M-acetic acid. The specificity of this reagent was tested by immunoelectro-* Present address :

show abstract

Reduction of Fertility in Female Mice Iso-Immunized With a Sub-Cellular Sperm Fraction

Abstract: Summary. Mouse

Cited by 46 publications

References 20 publications

Decreased Fertility in Female Mice Immunized With a Carrier Followed by Small Numbers of Spermatozoa

Decreased Fertility in Female Mice Immunized With a Carrier Followed by Small Numbers of Spermatozoa

Reproduction in rats and mice isoimmunized with homogenates of ovary or testis with epididymis, or sperm suspensions

An Antiglobulin Test for the Detection of Surface Antigens of Mouse Spermatozoa

Contact Info

Product

Resources

About