Reduction of food intake and body weight by chronic intraventricular insulin infusion

Brief, Deborah J.; Davis, John D.

doi:10.1016/0361-9230(84)90174-6

Cited by 203 publications

(99 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In summer, when the marmot is actively feeding, it responds to exogenously infused insulin like that reported in baboons (26) and rats (7,14). The dose of insulin chosen (20 mU/ marmot/day) is comparable on a units/kg/day basis to what is effective in rats (7,14).…”

Section: Discussionmentioning

confidence: 82%

“…The lag of several days for the insulin effect to become apparent is consistent with an initial recovery period (from the stress of the pump implantation) followed by a period of insulin action. Previous studies in which insulin was infused intraventricularly into rats (7,14) and baboons (26) also reported a lag of several days before food intake was reduced. It is noteworthy that the decrease in food intake that occurred was sufficient to account for the relatively small decrease in body weight.…”

Section: Discussionmentioning

confidence: 91%

“…Consistent with this hypothesis, administration of exogenous insulin directly into the CNS causes a dose-dependent reduction of food intake and body mass in baboons (26) and rats (1,7,14). Likewise, administration of insulin antibodies into the CNS causes an increase of food intake (20) and body mass (18) of rats.…”

mentioning

confidence: 79%

“…Unfortunately, food intake measurements could not be obtained following the termination of the experiment, but casual observations suggested that it had returned to normal. Both rats (7,14) and baboons (26) demonstrate hyperphagia and rebound of lost weight following termination of intraventricular insulin.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period

Florant

Singer

Scheurink

et al. 1991

Physiology & Behavior

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period

Florant

Singer

Scheurink

et al. 1991

Physiology & Behavior

View full text Add to dashboard Cite

“…Most knowledge regarding insulin receptor signalling comes from studies in classical insulin target tissues such as fat, muscle and the liver, where insulin is essential for regulating energy functions such as glucose and lipid metabolism. Unlike its peripheral counterpart, the central insulin receptor is involved in anorexigenic responses, fertility and reproduction, memory formation, and neuronal survival, and is considered to have no direct effect on neuronal glucose metabolism [14][15][16][17][18][19][20].…”

Section: Receptor Is Regulated By Tyrosine Phosphorylationmentioning

confidence: 99%

H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria

Помыткин¹

2012

View full text Add to dashboard Cite

This review is focused on the mechanistic aspects of the insulin-induced H 2 O 2 signalling pathway in neurons and the molecules affecting it, which act as risk factors for developing central insulin resistance. Insulin-induced H 2 O 2 promotes insulin receptor activation and the mitochondria act as the insulin-sensitive H 2 O 2 source, providing a direct molecular link between mitochondrial dysfunction and irregular insulin receptor activation. In this view, the accumulation of dysfunctional mitochondria during chronological ageing and Alzheimer's disease (AD) is a risk factor that may contribute to the development of dysfunctional cerebral insulin receptor signalling and insulin resistance. Due to the high significance of insulin-induced H 2 O 2 for insulin receptor activation, oxidative stress-induced upregulation of antioxidant enzymes, e.g., in AD brains, may represent another risk factor contributing to the development of insulin resistance. As insulin-induced H 2 O 2 signalling requires fully functional mitochondria, pharmacological strategies based on activating mitochondria biogenesis in the brain are central to the treatment of diseases associated with dysfunctional insulin receptor signalling in this organ.

show abstract

Hunger and Energy Homeostasis

Woods

Seeley

2002

Stevens' Handbook of Experimental Psychology

View full text Add to dashboard Cite

Food intake is a complex behavior so integral to our everyday experience that its complex and redundant biological underpinnings are often ignored or misunderstood. The biological control of ingestive behavior is multifold. First, there are a number of biological systems that operate within a single meal to bring that individual bout of ingestion to an end. While the initiation of meals appears to be influenced primarily by learned environmental cues, satiety signals, including those from the stomach, the intestine, and the liver, provide information to the CNS concerning the number of calories that have been consumed to terminate ingestion. Second, adult mammals also maintain relatively constant levels of stored calories in the form of adipose tissue. This is accomplished via a number of circulating adiposity signals that provide information to the CNS about changes in the amount of adipose in the body. Changes in these adiposity signals that reflect depletions of stored calories result in a complex neuroendocrine response that acts to conserve ongoing calorie usage and push the organism to ingest additional calories. Ultimately these adiposity signals act to alter food intake by adjusting the efficacy of satiety signals to influence food intake within a single bout of ingestion.

show abstract

Reduction of food intake and body weight by chronic intraventricular insulin infusion

Cited by 203 publications

References 27 publications

Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period

Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period

H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria

Hunger and Energy Homeostasis

Contact Info

Product

Resources

About