Reduction of ICAM-1 and LFA-1-positive leukocytes in the perivascular space of arteries under mycophenolate mofetil therapy reduces rat heart transplant vasculopathy

Richter, Markus; Zahn, Steffen; Richter, H; Mohr, Friedrich W.; Olbrich, H. G.

doi:10.1016/j.healun.2003.09.003

Cited by 11 publications

(4 citation statements)

References 39 publications

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“…At the end of the large, multiarmed study of Richter et al, the MMF group showed the mildest coronary vessel disease in their transplanted hearts 27 . MMF also reduced the migration of host LFA‐1 + leukocytes into the myocardium and perivascular spaces of graft arteries, and decreased endothelial expression of the cell adhesion molecule ICAM‐1 28 . This same dose of MMF reduced immunoreactivity for CD4, CD8, CD11a, and CD18 in the perivascular space around intracardiac and epicardiac arteries of rat heart allografts, indicative of reduced leukocyte infiltration 27 …”

Section: Preclinical Studies In Animalsmentioning

confidence: 99%

Mycophenolate Mofetil and Atherosclerosis

Gibson

Hayden

2007

Annals of the New York Academy of Sciences

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The immunosuppressive agent mycophenolate mofetil (MMF) has beneficial effects in cardiac transplant patients beyond the suppression of tissue rejection. Patients with regimens containing MMF experience diminished intimal thickening and cardiac allograft vasculopathy compared to patients treated with azathioprine. Studies have shown that diet-induced atherosclerosis (a related vasculopathy) is a chronic inflammatory process, and so MMF has also been used to reduce atherosclerosis in a rabbit model of hyperlipidemia. These data hold out the intriguing possibility that MMF might be a viable primary or secondary preventive agent in people at significant risk for atherosclerosis.

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Section: Preclinical Studies In Animalsmentioning

confidence: 99%

Mycophenolate Mofetil and Atherosclerosis

Gibson

Hayden

2007

Annals of the New York Academy of Sciences

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“…In a rat heterotopic heart transplantation model, a significant reduction in ICAM-1 expression was observed in mycophenolate mofetil (MMF)-treated animals. 43 In addition, LFA-1 infiltration and TIH were reduced when compared with a group treated with cyclosporine and tacrolimus (FK 506).…”

mentioning

confidence: 98%

Anti–LFA-1 Monotherapy Prevents Neointimal Formation in a Murine Model of Transplant Intimal Hyperplasia

Soleimani¹,

Wieczorek

Katopodis

et al. 2007

The Journal of Heart and Lung Transplantation

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“…The discordance between rejection and graft survival was credited to an independent protective effect of MPA. This independent protective effect has been demonstrated previously in animal models of both renal and cardiac transplantation and has been attributed to reduction in leukocyte infiltration and resultant graft vasculopathy . It is unknown if this is a dose‐related effect; however, the animal models cited used weight‐based dosing equivalent to 3000 mg per day or greater.…”

Section: Discussionmentioning

confidence: 64%