Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide

Szerlauth, Adél; Madácsy, Tamara; Samu, Gergely Ferenc; Bíró, Péter; Erdélyi, Miklós; Varga, Gábor; Xu, Zhi Ping; Maléth, József; Szilágyi, István

doi:10.1039/d3cc05762c

Chem. Commun.

2024

DOI: 10.1039/d3cc05762c

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Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide

Adél Szerlauth,

Tamara Madácsy,

Gergely Ferenc Samu

et al.

Abstract: Biocompatible Cu(II)-doped layered double hydroxide (CMA) nanoparticles were developed to combat reactive oxygen species. The 2-dimensional nanozymes showed both superoxide dismutase and catalase-like activity in chemical assays, while proved as...

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Cited by 3 publications

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Coamplified Nanozyme Cocktails for Cascade Reaction-Driven Antioxidant Treatments

Halmagyi,

Voros,

Saringer

et al. 2024

ACS Appl. Mater. Interfaces

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Antioxidant nanozymes are powerful tools to combat oxidative stress, which can be further improved by applying nanozyme mixtures of multiple enzymatic function. Here, cocktails of Prussian blue (PB) nanocubes and copper(II) exchanged ZSM-5 zeolites (CuZ) with enhanced reactive oxygen species (ROS) scavenging activity were developed. Surface functionalization of the particles was performed using polymers to obtain stable colloids, i.e., resistant to aggregation, under a wide range of experimental conditions. The nanozyme cocktails possessed advanced antioxidant properties with multiple enzyme-like functions, catalyzing the decomposition of ROS in cascade reactions. The activity of the mixture far exceeded that of the individual particles, particularly in the peroxidase assay, where an improvement of more than an order of magnitude was observed, pointing to coamplification of the enzymatic activity. In addition, it was revealed that the copper(II) site in the CuZ plays an important role in the decomposition of both superoxide radicals and hydrogen peroxide, as it directly catalyzes the former reaction and acts as cocatalyst in the latter process by boosting the peroxidase activity of the PB nanozyme. The results give important insights into the design of synergistic particle mixtures for the broad-spectrum scavenging of ROS to develop efficient tools for antioxidant treatments in both medical therapies and industrial manufacturing processes.

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Coamplified Nanozyme Cocktails for Cascade Reaction-Driven Antioxidant Treatments

Halmagyi,

Voros,

Saringer

et al. 2024

ACS Appl. Mater. Interfaces

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show abstract

Papain functionalized Prussian blue nanozyme colloids of triple enzymatic function

Voros,

Halmagyi,

Saringer

et al. 2024

Chem. Commun.

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Engineering inorganic nanozyme architectures for decomposition of reactive oxygen species

Halmagyi,

Noureen,

Szerlauth

et al. 2024

Dalton Trans.

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Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide

Abstract: Biocompatible Cu(II)-doped layered double hydroxide (CMA) nanoparticles were developed to combat reactive oxygen species. The 2-dimensional nanozymes showed both superoxide dismutase and catalase-like activity in chemical assays, while proved as...

Cited by 3 publications

References 29 publications

Coamplified Nanozyme Cocktails for Cascade Reaction-Driven Antioxidant Treatments

Coamplified Nanozyme Cocktails for Cascade Reaction-Driven Antioxidant Treatments

Papain functionalized Prussian blue nanozyme colloids of triple enzymatic function

Engineering inorganic nanozyme architectures for decomposition of reactive oxygen species

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