Reduction of ischemic myocardial necrosis by lidocaine administration

Myocardial protective effect of lidocaine hydrochloride on the ischemic myocardium was evaluated by serum (MB-CK) and cardiac function in 48 patients; 24 patients in control (C) and 24 patients in lidocaine-treated group (L), who underwent aorto-coronary bypass surgery. Lidocaine hydrochloride, 1 mg/min was administered by continuous drip infusion from initiation of anesthesia, and throughout the operation and postoperative period for 24 hours. There were no significant differences between two groups with regard to duration of cardioplegia and cardiopulmonary bypass, hypothermic level and the number of grafts implanted. Serum MB-CK at 18-24 hours following cardioplegia was 39.5 +/- 15.2 I.U. (C) and 14.2 +/- 4.0 I.U. (L), (p less than 0.05). Cardiac index and stroke volume index were significantly increased in the lidocaine-treated group at 24 hours following aorto-coronary bypass surgery, as compared to the control group. Lidocaine thus appears to be beneficial in aorto-coronary bypass surgery to prevent ischemic changes in the myocardium.

show abstract

Myocardial protection by lidocaine hydrochloride in aorto-coronary bypass surgery

Sunamori

Okamura

Amano

et al. 1982

The Japanese Journal of Surgery

View full text Add to dashboard Cite

show abstract

Myocardial preservation using lidocaine blood cardioplegia

Fiore

Naunheim

Taub

et al. 1990

The Annals of Thoracic Surgery

View full text Add to dashboard Cite

Protective effect of lidocaine in reperfused ischemic myocardium - Evaluation by hemodynamic and biochemical study.

Okamura¹,

Sunamori²,

Suzuki³

1982

Jpn Circ J

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Reduction of ischemic myocardial necrosis by lidocaine administration

Cited by 4 publications

References 0 publications

Myocardial protection by lidocaine hydrochloride in aorto-coronary bypass surgery

Myocardial protection by lidocaine hydrochloride in aorto-coronary bypass surgery

Myocardial preservation using lidocaine blood cardioplegia

Protective effect of lidocaine in reperfused ischemic myocardium - Evaluation by hemodynamic and biochemical study.

Contact Info

Product

Resources

About