Reduction of measurement uncertainty by experimental design in high-order (double, triple, and quadruple) isotope dilution mass spectrometry: application to GC-MS measurement of bromide

Pagliano, Enea; Mester, Zoltán; Meija, Juris

doi:10.1007/s00216-013-6724-5

Cited by 67 publications

(50 citation statements)

References 16 publications

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“…One such design is E 1,4 which corresponds to {R 1 , R 2 , R 3 } ≈ {1, 2, 1 2 }. Similar conclusions were obtained in our earlier work on ID 4 MS where good performance was observed when the three calibration blends were selected such that {R 1 , R 2 , R 3 } ≈ {1, 2, 1 2 } and the sample blend was selected such that R 4 = 1 [9,14].…”

Section: Mssupporting

confidence: 84%

Reducing the matrix effects in chemical analysis: fusion of isotope dilution and standard addition methods

Meija

2016

Metrologia

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The combination of isotope dilution and mass spectrometry has become an ubiquitous tool of chemical analysis. Often perceived as one of the most accurate methods of chemical analysis, it is not without shortcomings. Current isotope dilution equations are not capable of fully addressing one of the key problems encountered in chemical analysis: the possible effect of sample matrix on measured isotope ratios. The method of standard addition does compensate for the effect of sample matrix by making sure that all measured solutions have identical composition. While it is impossible to attain such condition in traditional isotope dilution, we present equations which allow for matrix-matching between all measured solutions by fusion of isotope dilution and standard addition methods.

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Section: Mssupporting

confidence: 84%

Reducing the matrix effects in chemical analysis: fusion of isotope dilution and standard addition methods

Meija

2016

Metrologia

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“…is known as quadruple isotope dilution (ID 4 MS) [1][2][3] and it involves only the gravimetric data regarding the four blends along with their isotopic composition. Note that the variables w B , R B , and R A have been eliminated in Eq.…”

Section: Solutionmentioning

confidence: 99%

Solution to the isotope dilution challenge

Pagliano

2015

Anal Bioanal Chem

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The award entitles the winning groups to select a Springer book of their choice up to a value of €100,-.Our Congratulations! SolutionOver the years, isotope dilution mass spectrometry (IDMS) has witnessed many reformulations. One of the earliest expressions for this quantitation model was given by the single isotope dilution (ID 1 MS). In ID 1 MS, the mass fraction of an analyte A is obtained from mass spectrometric analysis of a mixture (blend) of sample and an isotopically-enriched form of the analyte (B) which acts as an internal standard:This model requires that the mass fraction of the isotopic standard (w B ), the isotopic composition of natural (R A ) and enriched (R B ) material, and their respective molar masses (M A and M B ) are known beforehand. It is possible, however, to design an experiment in order to bypass the prior knowledge of these quantities. For example, in addition to the blend of sample and isotopic standard (AB), one can prepare and measure three additional blends of a primary standard (with natural isotopic composition) and isotopic standard. These blends are denoted A*B-1, A*B-2, A*B-3, and the following system of four equations now describes the experiment, assuming R A =R A* and M A =M A* :Equation 2 can be solved for w A to yield:whereThis article is the solution to the Analytical Challenge to be found at http://dx

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“…Calibration plots were obtained by plotting the observed isotope ratio of 81 Br to 79 Br versus the variable w A (m A /m A ) where w A is the mass fraction of bromide in the natural standard, m A is the mass of the natural standard aliquot, and m B is the mass of the isotopic internal standard (bromine-79 labeled bromide) added to the sample aliquot. More detailed account of this method are not pertinent to this manuscript and these can be consulted elsewhere, if necessary [11,18]. Supporting Information provides all measurement results employed in this manuscript.…”

Section: Methodsmentioning

confidence: 99%

“…In particular, the isotope dilution equation [11] inverts with respect to R AB into a first-order Padé function,…”

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Calibration graphs in isotope dilution mass spectrometry

Mester

Meija

2015

Analytica Chimica Acta

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Access and use of this website and the material on it are subject to the Terms and Conditions set forth at Calibration graphs in isotope dilution mass spectrometry Pagliano, Enea; Mester, Zoltán; Meija, Juris http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=fr L'accès à ce site Web et l'utilisation de son contenu sont assujettis aux conditions présentées dans le site LISEZ CES CONDITIONS ATTENTIVEMENT AVANT D'UTILISER CE SITE WEB. NRC Publications Record / Notice d'Archives des publications de CNRC:http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=21276802&lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=21276802&lang=fr READ THESE TERMS AND CONDITIONS CAREFULLY BEFORE USING THIS WEBSITE.http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions? Contact the NRC Publications Archive team atPublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://doi.org/10.1016/j.aca.2015.09.020Analytica Chimica Acta, 896, pp. 63-67, 2015-10-08 Calibration graphs in isotope dilution mass spectrometry Enea Pagliano, Zoltan Mester and Juris Meija Measurement Science and Standards, National Research Council Canada, 1200 Montreal Road, Ottawa ON K1A 0R6, Canada E-mail: juris.meija@nrc-cnrc.gc.ca Abstract. Isotope-based quantitation is routinely employed in chemical measurements. Whereas most analysts seek for methods with linear theoretical response functions, a unique feature that distinguishes isotope dilution from many other analytical methods is the inherent possibility for a nonlinear theoretical response curve. Most implementations of isotope dilution calibration today either eliminate the nonlinearity by employing internal standards with markedly different molecular weight or they employ empirical polynomial fits. Here we show that the exact curvature of any isotope dilution curve can be obtained from threeparameter rational function, y = f (q) = (a 0 + a 1 q)/(1 + a 2 q), known as the Padé[1,1] approximant. The use of this function allows eliminating an unnecessary source of error in isotope dilution analysis when faced with nonlinea...

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Reduction of measurement uncertainty by experimental design in high-order (double, triple, and quadruple) isotope dilution mass spectrometry: application to GC-MS measurement of bromide

Cited by 67 publications

References 16 publications

Reducing the matrix effects in chemical analysis: fusion of isotope dilution and standard addition methods

Reducing the matrix effects in chemical analysis: fusion of isotope dilution and standard addition methods

Solution to the isotope dilution challenge

Calibration graphs in isotope dilution mass spectrometry

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