Reduction of mitochondrial DNA copy number in peripheral blood is related to polycyclic aromatic hydrocarbons exposure in coke oven workers: Bayesian kernel machine regression

Zhao, Xinyu; Yang, Aimin; Fu, Ye; Zhang, Bin; Li, Xuejing; Pan, Baolong; Li, Qiang; Dong, Jun; Nie, Jing; Yang, Jin

doi:10.1016/j.envpol.2020.114026

Cited by 20 publications

(7 citation statements)

References 56 publications

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“…Higher mtDNAcn was previously detected in the peripheral blood of workers chronically exposed to PAHs 33 . In contrast, other authors observed decreased mtDNAcn in peripheral blood in association with exposure to PAHs 34 , 35 . Increased blood mtDNAcn was also found associated with traffic-related air pollution 36 , 37 and exposure to benzene 38 .…”

Section: Discussionmentioning

confidence: 63%

Association between sperm mitochondrial DNA copy number and deletion rate and industrial air pollution dynamics

Vozdová

Kubı́čková

Kopecka

et al. 2022

Sci Rep

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The effects of air pollution on men’s reproductive health can be monitored by evaluating semen quality and sperm DNA damage. We used real-time PCR to analyse the effects of air pollution on sperm mitochondrial DNA copy number (mtDNAcn) and deletion (mtDNAdel) rates in semen samples collected from 54 men in two seasons with different levels of industrial and traffic air pollution. MtDNAdel rates were significantly higher following the high exposure period and were positively correlated with mtDNAcn. However, we did not find any difference in mtDNAcn between the two seasons. MtDNAcn was positively correlated with the DNA fragmentation index and the rates of sperm with chromatin condensation defects, previously assessed by sperm chromatin structure assay, and negatively correlated with sperm concentration, progressive motility, viability, and normal morphology. This indicates that mtDNAcn is more closely associated with male fertility than mtDNAdel rates. In contrast, mtDNAdel might be a more sensitive biomarker of air pollution exposure in urban industrial environments.

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Section: Discussionmentioning

confidence: 63%

Association between sperm mitochondrial DNA copy number and deletion rate and industrial air pollution dynamics

Vozdová

Kubı́čková

Kopecka

et al. 2022

Sci Rep

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“…40,41 Due to its sensitivity and specificity, urinary 1-OHP is usually used as a biomarker to evaluate high PAH exposure. 42 We found that urinary 1-OHP negatively associated with the levels of GATA3 or T-bet. This finding suggested that PM might lead to immune impairment.…”

Section: Discussionmentioning

confidence: 66%

“…PAHs, a type of toxic constituents in PM, are known to be potential carcinogens and the main cause of lung cancer in the PM-exposed population, the underlying mechanism may include immune impairments. , Due to its sensitivity and specificity, urinary 1-OHP is usually used as a biomarker to evaluate high PAH exposure . We found that urinary 1-OHP negatively associated with the levels of GATA3 or T-bet .…”

Section: Discussionmentioning

confidence: 74%

Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

Meng

Wang

et al. 2022

Environ. Sci. Technol.

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Compared with the T-cell potential of particulate matter (PM) in animal studies, comprehensive evaluation on the impairments of T-cell response and exposure−response from PM and its components in human population is limited. There were 768 participants in this study. We measured environmental PM and its polycyclic aromatic hydrocarbons (PAHs) and metals and urinary metabolite levels of PAHs and metals among population. T lymphocyte and its subpopulation (CD4 + T cells and CD8 + T cells) and the expressions of T-bet, GATA3, RORγt, and FoxP3 were measured. We explored the exposure−response of PM compositions by principal component analysis and mode of action by mediation analysis. There was a significant decreasing trend for T lymphocytes and the levels of T-bet and GATA3 with increased PM levels. Generally, there was a negative correlation between PM, urinary 1-hydroxypyrene, urinary metals, and the levels of T-bet and GATA3 expression. Additionally, CD4 + T lymphocytes were found to mediate the associations of PM 2.5 with T-bet expression. PM and its bound PAHs and metals could induce immune impairments by altering the T lymphocytes and genes of T-bet and GATA3.

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“…Thirdly, a new flexible statistical method, the BKMR model is utilized to quantify and visualize the cumulative effects and dose-response relationships of serum metal mixtures in continuous variables. This approach reduces measurement bias and overcomes limitations associated with traditional analytical methods ( 32 ). However, this study also has some limitations.…”

Section: Discussionmentioning

confidence: 99%

Comparative mathematical modeling of causal association between metal exposure and development of chronic kidney disease

Wu,

Hou,

Qin

et al. 2024

Front. Endocrinol.

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BackgroundPrevious studies have identified several genetic and environmental risk factors for chronic kidney disease (CKD). However, little is known about the relationship between serum metals and CKD risk.MethodsWe investigated associations between serum metals levels and CKD risk among 100 medical examiners and 443 CKD patients in the medical center of the First Hospital Affiliated to China Medical University. Serum metal concentrations were measured using inductively coupled plasma mass spectrometry (ICP-MS). We analyzed factors influencing CKD, including abnormalities in Creatine and Cystatin C, using univariate and multiple analysis such as Lasso and Logistic regression. Metal levels among CKD patients at different stages were also explored. The study utilized machine learning and Bayesian Kernel Machine Regression (BKMR) to assess associations and predict CKD risk based on serum metals. A chained mediation model was applied to investigate how interventions with different heavy metals influence renal function indicators (creatinine and cystatin C) and their impact on diagnosing and treating renal impairment.ResultsSerum potassium (K), sodium (Na), and calcium (Ca) showed positive trends with CKD, while selenium (Se) and molybdenum (Mo) showed negative trends. Metal mixtures had a significant negative effect on CKD when concentrations were all from 30th to 45th percentiles compared to the median, but the opposite was observed for the 55th to 60th percentiles. For example, a change in serum K concentration from the 25th to the 75th percentile was associated with a significant increase in CKD risk of 5.15(1.77,8.53), 13.62(8.91,18.33) and 31.81(14.03,49.58) when other metals were fixed at the 25th, 50th and 75th percentiles, respectively.ConclusionsCumulative metal exposures, especially double-exposure to serum K and Se may impact CKD risk. Machine learning methods validated the external relevance of the metal factors. Our study highlights the importance of employing diverse methodologies to evaluate health effects of metal mixtures.

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Reduction of mitochondrial DNA copy number in peripheral blood is related to polycyclic aromatic hydrocarbons exposure in coke oven workers: Bayesian kernel machine regression

Cited by 20 publications

References 56 publications

Association between sperm mitochondrial DNA copy number and deletion rate and industrial air pollution dynamics

Association between sperm mitochondrial DNA copy number and deletion rate and industrial air pollution dynamics

Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

Comparative mathematical modeling of causal association between metal exposure and development of chronic kidney disease

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