Reduction of murine mammary tumor metastasis by conjugated linoleic acid

Hubbard, Neil E.; Lim, Debora; Summers, Lauri; Erickson, Kent L.

doi:10.1016/s0304-3835(99)00379-1

Cited by 71 publications

(32 citation statements)

References 26 publications

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“…Isomer t10, c12-18:2 a powerful inhibitor of the synthesis of fat in milk and responsible for the redistribution of fat in muscle, contributing to reduce the fat mass and increase the lean mass (Mourão et al, 2005;Dugan et al, 1997;Chardigny et al, 2003;Gaullier et al, 2005;Degrace et al, 2003). Isomer c9, t11-18:2 has demonstrated antitumoral properties, reducing the incidence of breast cancer (Mourão et al, 2005;Dugan et al, 1997;Chardigny et al, 2003;Gaullier et al, 2005;Degrace et al, 2003;Ou et al, 2007;Lavillonnière et al, 2003;Belury et al, 1996;Hubbard et al, 2000;Molkentin, 1999;Chardigny et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid Content of Bovine Milkfat From Raw Milk to Yoghurt

Júnior¹,

Pedrão²,

Dias³

et al. 2012

American Journal of Applied Sciences

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Problem statement:The present study aimed to study the evolution of fatty acid content, focusing on rumenic acid content, from raw milk to yoghurt processed from this milk. Approach: Milk samples were collected in a dairy plant in the northwest of Paraná State weekly in January 2011 (Brazilian summer). It processed one truck load of 26,000 L of refrigerated type-C (whole standardized milk with a minimum of 3% fat) milk per day, mostly from the city of Lobato, Paraná, produced mainly by Gir (Bos indicus) cattle raised on stargrass (Cynodon nlenfuensis var. nlenfuensis) pasture. Results: Saturated Fatty Acid (SFA) were the most abundant, particularly palmitic (16:0), stearic (18:0) and myristic (14:0). Among the Monounsaturated Fatty Acid (MUFA), Polyunsaturated Fatty Acid (PUFA) and trans fatty acid, oleic acid (18:1n-9), linoleic acid (18:2n-6), elaidic acid (t9-18:1) and c9, t11-18:2 (rumenic acid) predominated. It was detected significant differences (p<0.05) in the quantification of isomer c9, t11-18:2 of Conjugated Linoleic Acid (CLA).

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Section: Introductionmentioning

confidence: 99%

Fatty Acid Content of Bovine Milkfat From Raw Milk to Yoghurt

Júnior¹,

Pedrão²,

Dias³

et al. 2012

American Journal of Applied Sciences

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“…Numerous studies using various animal models support the hypothesis that both synthetic and naturally enriched sources of CLA added to the diet inhibit mammary tumour initiation [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34], promotion and progression [35][36][37][38][39][40][41] in rodents ( Table 2). A range of 0.1% to 1% w/w of CLA, independent of the level and type of fat in the diet, has shown to be effective, with no further benefits beyond 1% w/w [19,24].…”

Section: Animal Studies Of Cla and Mammary Cancermentioning

confidence: 97%

The Role of Conjugated Linoleic Acid in Breast Cancer Growth and Development

Amarù¹,

Biondo²,

Field³

2010

TONUTRAJ

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Conjugated linoleic acid (CLA) consists of a group of naturally occurring and synthetic positional and geometric (cis-trans) stereoisomers of the polyunsaturated fatty acid linoleic acid. The cis-9,trans-11 (c9,t11) CLA isomer (the most prevalent form found in ruminant-derived foods) and the trans-10,cis-12 (t10,c12) CLA isomer (present in commercial preparations) are the two most widely studied CLA isomers in breast cancer. Studies using both animal and cell culture models indicate that these CLA isomers, when added to the diet or included in the cell culture medium, inhibit mammary tumour initiation, promotion and progression in rodents, and alter tumour cell viability in vitro. The mechanism of CLA's anticancer effect is not well understood, but may involve interference with the cell cycle, induction of apoptosis, modulation of gene expression via the activation of peroxisome proliferator-activated receptors, lipid peroxidation, modulation of the tumour microenvironment, changes to the structure and/or function of the cell membrane, and interference with growth factor receptor signaling. A greater understanding of the mechanism of action of CLA will support the development of clinical trials to evaluate the potential effectiveness of CLA in the treatment of breast cancer.

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“…An inhibitory effect of CLA has been reported at different stages: initiation, promotion and tumourgrowth [30], and metastasis formation [31]. Prepubescent female rats supplemented with CLA before carcinogen induction [dimethylbenz(a)anthracen (DMBA) or N-methyl nitroso urea (NMU)] developed significantly fewer mammary tumours than the control rats (47%) [27], suggesting that the presence of CLA within mammary tissues made them less sensitive to initiation by a carcinogenic agent.…”

Section: Cla and Mammary Tumorigenesismentioning

confidence: 98%

Trans fatty acids and cancers: AFSSA recommendations

Gerber¹,

Razanamahefa²,

Bougnoux³

2007

Euro J Lipid Sci & Tech

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The results of epidemiological studies were too few and inconsistent to enable a conclusion to be drawn as to whether dietary trans fatty acids (TFA) including conjugated linoleic acids (CLA) were beneficial or detrimental to the various sites of cancer studied. The effect of CLA isomers has only been studied in animal models, and mainly on mammary tumours. CLA -particularly the 9c,11t CLA -exerted an inhibitory effect on the initiation and development of these tumours, whereas a similar effect has not been observed in humans, whose intake level is much lower than the threshold required for an antitumour effect to be detectable in rodents. The aforementioned effect has been obtained in animal models at prolonged and high intakes, from 0.5 to 2% of the total energy intake, which corresponds approximately to 5-10 g/day in humans. The underlying mechanisms have not been identified and are probably indirect and multiple.

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Reduction of murine mammary tumor metastasis by conjugated linoleic acid

Cited by 71 publications

References 26 publications

Fatty Acid Content of Bovine Milkfat From Raw Milk to Yoghurt

Fatty Acid Content of Bovine Milkfat From Raw Milk to Yoghurt

The Role of Conjugated Linoleic Acid in Breast Cancer Growth and Development

Trans fatty acids and cancers: AFSSA recommendations

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