2024
DOI: 10.1002/ctm2.70048
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Reduction of myeloid‐derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment

Xiaoqiang Wang,
Shoubao Ma,
Przemyslaw Twardowski
et al.

Abstract: BackgroundIn a previously reported Phase I trial, we observed therapy‐associated declines in circulating myeloid‐derived suppressor cells (MDSCs) with the administration of white button mushroom (WBM) tablets in prostate cancer (PCa) patients. These observations led us to hypothesise that WBM could mitigate PCa progression by suppressing MDSCs.MethodsWe performed bidirectional translational research to examine the immunomodulatory effects of WBM consumption in both syngeneic murine PCa models and patients with… Show more

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