Reduction of Myocardial Ischemia-Reperfusion Injury by Mechanical Tissue Resuscitation Using Sub-Atmospheric Pressure

Argenta, Louis C.; Morykwas, Michael J.; Mays, J B S Jennifer; Thompson, Andrew; Hammon, John W.; Jordan, James

doi:10.1111/j.1540-8191.2009.00972.x

Cited by 9 publications

(19 citation statements)

References 18 publications

(30 reference statements)

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“…MTR administered immediately upon reperfusion has previously been shown to reduce myocardial edema, infarct size, and apoptosis . Here, MTR reduced infarct size by nearly 50% even though treatment was delayed for 90 minutes (half of the total reperfusion period).…”

Section: Discussionmentioning

confidence: 73%

“…Hemodynamics and arterial blood gases were recorded at baseline, middle, and end of ischemia (mid‐ and end‐isc), as well as at 30 (R30), 60 (R60), 120 (R120), and 180 (R180) minutes of reperfusion. MTR‐treatment was applied 90 minutes after reperfusion and was accomplished using a polyvinyl–alcohol sponge, nitrile sheet, and a vacuum tube attached to a computer‐controlled vacuum pump as previously described . Evicel glue (Ethicon, Somerville, NJ, USA) was used to seal the edges of the nitrile to the myocardium creating an airtight patch.…”

Section: Methodsmentioning

confidence: 99%

“…Infarct size was determined by gravimetric analysis as previously described . Briefly, the coronary ligatures were permanently tightened and a blue dye was used to negatively stain the area at risk (AAR).…”

Section: Methodsmentioning

confidence: 99%

“…Regional myocardial blood flow was assessed at baseline, end of ischemia, R30, and R180 using neutron‐activated microspheres as previously described . Microspheres were injected centrally into the left atrium and reference blood samples were collected from the femoral artery.…”

Section: Methodsmentioning

confidence: 99%

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Mechanical Tissue Resuscitation (MTR): A Nonpharmacological Approach to Treatment of Acute Myocardial Infarction

et al. 2015

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Section: Discussionmentioning

confidence: 73%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Mechanical Tissue Resuscitation (MTR): A Nonpharmacological Approach to Treatment of Acute Myocardial Infarction

et al. 2015

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“…A study using a rat cremaster model supports the contention that this phenomenon is real and is remedied at the microscopic level by early use of negative pressure wound therapy by enhancing the resolution of interstitial edema and clearance of albumin from the third space [31]. Relevant to these mechanisms, animal studies have shown successful use of negative pressure wound therapy in favorably preserving tissue in the setting of myocardial infarction or brain tissue loss after closed head trauma [3,4,34]. Given the evidence provided in these settings, one may attribute some of the diminution in infection and improvements in tissue healing attributable to negative pressure wound therapy to avoidance of secondary necrosis.…”

Section: Corroborations From Basic Science and Other Disciplinesmentioning

confidence: 86%

Negative Pressure Wound Therapy in Grade IIIB Tibial Fractures: Fewer Infections and Fewer Flap Procedures?

Schlatterer

Hirschfeld

Webb

2015

Clinical Orthopaedics &Amp; Related Research

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Background Grade IIIB open tibia fractures are devastating injuries. Some clinicians advocate wound closure or stable muscle flap coverage within 72 hours to limit complications such as infection. Negative pressure wound therapy was approved by the FDA in 1997 and has become an adjunct for many surgeons in treating these fractures. Opinions vary regarding the extent to which negative pressure wound therapy contributes to limb salvage. Evidence-based practice guidelines are limited for use of negative pressure wound therapy in Grade IIIB tibia fractures. This systematic literature review of negative pressure wound therapy in Grade IIIB tibia fractures may substantiate current use and guide future studies. Questions/purposes We sought to answer the following:(1) Does the use of negative pressure would therapy compared with gauze dressings lead to fewer infections? (2) Does it allow flap procedures to be performed safely beyond 72 hours without increased infection rates? (3) Is it associated with fewer local or free flap procedures? Methods We conducted a systematic review of six large databases (through September 1, 2013) for studies reporting use of negative pressure wound therapy in Grade IIIB open tibia fractures, including information regarding infection rates and soft tissue reconstruction. The systematic review identified one randomized controlled trial and 12 retrospective studies: four studies compared infection rates between negative pressure wound therapy and gauze dressings, 10 addressed infection rates with extended use, and six reported on flap coverage rates in relation to negative pressure wound therapy use beyond 72 hours. None of the 13 studies was eliminated owing to lack of study quality.

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Exploring the integration of local and scientific knowledge in early warning systems for disaster risk reduction: a review

Hermans

Trogrlić

Homberg³

et al. 2022

Nat Hazards

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The occurrence and intensity of some natural hazards (e.g. hydro-meteorological) increase due to climate change, with growing exposure and socio-economic vulnerability, leading to mounting risks. In response, Disaster Risk Reduction policy and practice emphasize people-centred Early Warning Systems (EWS). Global policies stress the need for including local knowledge and increasing the literature on integrating local and scientific knowledge for EWS. In this paper, we present a review to understand and outline how local and scientific knowledge integration is framed in EWS, namely: (1) existing integration approaches, (2) where in the EWS integration happens, (3) outcomes, (4) challenges, and (5) enablers. The objective is to critically evaluate integration and highlight critical questions about assumptions, goals, outcomes, and processes. In particular, we unpack the impact of power and knowledges as plural. We find a spectrum of integration between knowledges in EWS, mainly with dichotomy at the start: focus on people or technology. The most popular integration approaches are participatory methods such as ‘GIS mapping’ (technology) and methods that focus on ‘triangulation’ (people). We find that critical analysis of power relations and social interaction is either missed or framed as a challenge within integration processes. Knowledge is often seen as binary, embedded in the concept of ‘integration’. It is important to know what different knowledges can and cannot do in different contexts and acknowledge the hybrid reality of knowledge used for EWS. We argue that how we approach different knowledges in EWS has fundamental implications for the approaches to integration and its meaning. To this end, attention to the social processes, power dynamics, and context is crucial.

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Reduction of Myocardial Ischemia-Reperfusion Injury by Mechanical Tissue Resuscitation Using Sub-Atmospheric Pressure

Cited by 9 publications

References 18 publications

Mechanical Tissue Resuscitation (MTR): A Nonpharmacological Approach to Treatment of Acute Myocardial Infarction

Mechanical Tissue Resuscitation (MTR): A Nonpharmacological Approach to Treatment of Acute Myocardial Infarction

Negative Pressure Wound Therapy in Grade IIIB Tibial Fractures: Fewer Infections and Fewer Flap Procedures?

Exploring the integration of local and scientific knowledge in early warning systems for disaster risk reduction: a review

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