Reduction of neural scarring after peripheral nerve suture: An experimental study about collagen membrane and autologous vein wrapping

Mathieu, L.; Adam, Christian; Legagneux, Josette; Bruneval, P; Masméjean, E.

doi:10.1016/j.main.2012.10.167

Cited by 26 publications

(18 citation statements)

References 19 publications

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“…Mathieu et al concluded that the collagen membrane was effective in reducing neural scar formation after peripheral nerve sutures. 10 Kim et al demonstrated that inner epineural connective tissue formation was decreased with the use of a collagen nerve wrap during primary repair of peripheral nerve transection in a rat sciatic nerve model. 11 However, no functional or electrophysiological evaluation was performed in both studies.…”

Section: Discussionmentioning

confidence: 99%

“…Bioabsorbable nerve conduits have been commonly applied to bridge the short segmental nerve defects, and may be used to protect scarred or repaired nerves as a nerve wrap. Recently, several studies demonstrated that use of nerve wraps after primary nerve repair can decrease epineural or intraneural scar tissue formation by morphometric and histologic analysis . However, they did not perform any functional evaluation of the nerve regeneration which is more important in clinical settings.…”

mentioning

confidence: 99%

“…Recently, several studies demonstrated that use of nerve wraps after primary nerve repair can decrease epineural or intraneural scar tissue formation by morphometric and histologic analysis. [10][11][12] However, they did not perform any functional evaluation of the nerve regeneration which is more important in clinical settings. This technique is nevertheless used clinically to decrease scar formation and to protect the primary nerve repair without scientific evidences.…”

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confidence: 99%

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Does the addition of a nerve wrap to a motor nerve repair affect motor outcomes?

et al. 2014

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The purpose of this study was to evaluate the effect of wrapping bioabsorbable nerve conduit around primary suture repair on motor nerve regeneration in a rat model. Forty rats were randomly divided into two experimental groups according to the type of repair of the rat sciatic nerve: group I had primary suture repair; group II had primary suture repair and bioabsorbable collagen nerve conduit (NeuraGen® 1.5 mm, Integra LifeSciences Corp., Plainsboro, NJ) wrapped around the repair. At 12 weeks, no significant differences in the percentage of recovery between the two groups were observed with respect to compound muscle action potentials, isometric muscle force, and muscle weight (P = 0.816, P = 0.698, P = 0.861, respectively). Histomorphometric analysis as compared to the non-operative sites was also not significantly different between the two groups in terms of number of myelinated axons, myelinated fiber area, and nerve fiber density (P = 0.368, P = 0.968, P = 0.071, respectively). Perineural scar tissue formation was greater in primary suture repair group (0.36 ± 0.15) than in primary repair plus conduit wrapping group (0.17 ± 0.08). This difference was statistically significant (P < 0.001). Wrapping bioabsorbable nerve conduit around primary nerve repair can decrease perineural scar tissue formation. Although the scar-decreasing effect of bioabsorbable nerve wrap does not translate into better motor nerve recovery in this study, it might have an effect on the functional outcome in humans where scar formation is much more evident than in rats.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Does the addition of a nerve wrap to a motor nerve repair affect motor outcomes?

et al. 2014

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“…Mathieu et al 67 wrapped rodent sciatic nerve repairs with vein or collagen and found that both decreased perineurial scarring though nerve healing did not seem to be altered compared with a nonwrapped repair. PCL sheeting is commercially available as a scar barrier, although we were unable to identify a single laboratory or clinical study to endorse this application.…”

Section: Off-the-shelf Optionsmentioning

confidence: 99%

Different nerve grafting and wrapping options in upper extremity surgery

Isaacs

McMurtry

2014

Current Orthopaedic Practice

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Scar tissue can interfere with axonal regeneration and ultimate nerve function. Resection of scar tissue, however, results either in a nerve defect (if the scar tissue is intraneural) or the potential for recurrent extraneural scarring. Both biologic and off-the-shelf options exist for bridging short nerve gaps though understanding their limitations will improve the chances of successful application. Similarly, an appreciation of the available biologic and off-the-shelf nerve wrapping options can facilitate choosing the most appropriate adhesion barrier.

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“…Nerve wrapping is sometimes conducted to prevent tissue adhesion/scarring of the nerve repair site . Nerve wraps work by inhibiting immune cell migration and preventing scar tissue formation at the repair site, however, the current clinically available nerve wraps lack added functionality to enhance nerve regeneration …”

Section: Introductionmentioning

confidence: 99%

Local FK506 delivery at the direct nerve repair site improves nerve regeneration

et al. 2019

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Introduction The objective of this study is to assess the efficacy of local tacrolimus (FK506) delivery to improve outcomes in the setting of nerve transection injury. Methods FK506 embedded poly(lactide‐co‐caprolactone) films capable of extended, localized release of FK506 were developed. FK506 rate of release testing and bioactivity assay was performed. Mouse sciatic nerve transection and direct repair model was used to evaluate the effect extended, local delivery of FK506 had on nerve regeneration outcomes. Results Linear release of FK506 was observed for 30 days and released FK506 matched control levels of neurite extension in the dorsal root ganglion assay. Groups treated with local FK506 had greater gastrocnemius muscle weight, foot electromyogram, and number of axons distal of the repair site than non‐FK506 groups. Discussion Results of this study indicate that extended, localized delivery of FK506 to nerve injuries can improve nerve regeneration outcomes in a mouse sciatic nerve transection and repair.

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Reduction of neural scarring after peripheral nerve suture: An experimental study about collagen membrane and autologous vein wrapping

Cited by 26 publications

References 19 publications

Does the addition of a nerve wrap to a motor nerve repair affect motor outcomes?

Does the addition of a nerve wrap to a motor nerve repair affect motor outcomes?

Different nerve grafting and wrapping options in upper extremity surgery

Local FK506 delivery at the direct nerve repair site improves nerve regeneration

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