Reduction of neutral lipid reservoirs, bioconversion and untargeted metabolomics reveal distinct roles for vitamin K isoforms on lipid metabolism

Silva, Natália Gonçalves; Preto, Marco; Vasconcelos, Vitor; Urbatzka, Ralph

doi:10.1039/d3fo02915h

Food Funct.

2024

DOI: 10.1039/d3fo02915h

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Reduction of neutral lipid reservoirs, bioconversion and untargeted metabolomics reveal distinct roles for vitamin K isoforms on lipid metabolism

Natália Gonçalves Silva,

Marco Preto,

Vitor Vasconcelos

et al.

Abstract: Vitamin K isoforms are known as co-factors for the synthesis of blood-clotting proteins, but several other bioactivities were reported. In this work, we isolated a vitamin K1-analogue (OH-PhQ) from the...

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Cited by 2 publications

References 48 publications

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Metabolite profiling and bioactivity assessment of cyanobacteria from the Azores reveals unique producers of cytotoxic and lipid reducing compounds

Luz,

Gonçalves,

Vasconcelos

et al. 2024

Algal Research

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Metabolite profiling and bioactivity assessment of cyanobacteria from the Azores reveals unique producers of cytotoxic and lipid reducing compounds

Luz,

Gonçalves,

Vasconcelos

et al. 2024

Algal Research

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Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules

Liu,

Li,

Wang

et al. 2024

Marine Drugs

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Marine natural products are increasingly utilized in nutrition, cosmetics, and medicine, garnering significant attention from researchers globally. With the expansion of marine resource exploration in recent years, the demand for marine natural products has risen, necessitating rapid and cost-effective activity evaluations using model organisms. Zebrafish, a valuable vertebrate model, has become an efficient tool for screening and identifying safe, active molecules from marine natural products. This review, based on nearly 10 years of literature, summarizes the current status and progress of zebrafish models in evaluating marine natural product bioactivity. It also highlights their potential in exploring marine resources with health benefits, offering a reference for the future development and utilization of marine biological resources.

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Reduction of neutral lipid reservoirs, bioconversion and untargeted metabolomics reveal distinct roles for vitamin K isoforms on lipid metabolism

Abstract: Vitamin K isoforms are known as co-factors for the synthesis of blood-clotting proteins, but several other bioactivities were reported. In this work, we isolated a vitamin K1-analogue (OH-PhQ) from the...

Cited by 2 publications

References 48 publications

Metabolite profiling and bioactivity assessment of cyanobacteria from the Azores reveals unique producers of cytotoxic and lipid reducing compounds

Metabolite profiling and bioactivity assessment of cyanobacteria from the Azores reveals unique producers of cytotoxic and lipid reducing compounds

Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules

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