Reduction of Organoselenium and Tellurium Halides and Oxides with Thiourea Dioxide

Lang, Ernesto S.; Comasseto, J. V.

doi:10.1080/00397918808057837

Cited by 34 publications

(6 citation statements)

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“…Thiourea dioxide (TDO, aminoiminomethanesulfinic acid) is widely used for reducing organosulfur, organoselenium, organotellurium, and organofluorine compounds. − It is also used as a component of the initiation systems for polymerization reactions . In biochemistry TDO is used in chemical modification studies to identify functionally important amino acids in Escherichia coli CTP synthetase .…”

Section: Introductionmentioning

confidence: 99%

A Possible Mechanism for Thiourea-Based Toxicities: Kinetics and Mechanism of Decomposition of Thiourea Dioxides in Alkaline Solutions

2001

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The decomposition kinetics of a series of thiourea dioxides has been studied in alkaline media. In aerobic conditions the decomposition is characterized by an induction period, which is followed by the formation of dithionite, S 2 O 4 2-. The rates of consumption of the thiourea dioxide and the formation of dithionite follow zero-order kinetics. No dithionite is formed in anaerobic conditions, although the thiourea dioxides can still rapidly decompose in the absence of oxygen to give sulfite and a urea as the decomposition products. No dithionite is formed until all the dioxygen in solution has been consumed, and hence the induction time is determined by the initial oxygen concentration in solution. A comprehensive mechanism that can adequately explain the decomposition is proposed in which the initial step is the cleavage of the C-S bond to give a urea residue and the sulfoxylate ion, SO 2 2-. The sulfoxylate ion is next rapidly oxidized by oxygen to give the anion radical, SO 2 -, which is the precursor to the formation of dithionite via a rapid equilibrium. In aerobic environments the sufoxylate ion can produce the highly tissue-damaging series of reactive oxygen species superoxide, peroxide, and hydroxyl radical. These species could be responsible for the inherent toxicities associated with thioureas.

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Section: Introductionmentioning

confidence: 99%

A Possible Mechanism for Thiourea-Based Toxicities: Kinetics and Mechanism of Decomposition of Thiourea Dioxides in Alkaline Solutions

2001

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“…In addition, in this study, we found that the great Brazilian authors' contribution occurs mainly in the area of "organoselenium" acting in the organic synthesis, pharmacology or toxicology lines. Here, we would like to highlight the great importance of the organoselenium research of Brazil, once Brazil is in the first position of published documents and the first organoselenium Brazilian document was recently published (see Lang & Comasseto et al, (1988)). In addition, we can say that the presence of Brazil in the research is "youthful", once the first masters and PhDs courses of this country started 65 years ago (Bianchetti & Fávero 2005;Cirani et al, 2015;Nobre & Freitas, 2017).…”

Section: Positionmentioning

confidence: 99%

The evolution of Selenium and Mercury research from 1700 to 2017 based on bibliometric analysis

Nogara

Schmitz

Costa³

et al. 2020

RSD

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Selenium and Mercury are two chemical elements studied in several fields of knowledge due to their chemical properties and interactions. The aim of this study was to analyze the evolution of research activity from 1700 to 2017 on the global trend of these elements, we carried out a bibliometric analysis using the Scopus database. For each keyword accessed (“selenium”, “selenide”, “selenite”, “selenate”, “organoselenium”, “mercury”, “inorganic mercury”, “mercury vapor” and “methylmercury”), we analyzed the publication output, and the top 5 geographic distribution of publications and contributing authors, as well as the top 5 Scopus subject categories where the documents are indexed. The results demonstrated an increase in the number of publication over time for all the keywords. Research about Selenium and its inorganic and organic chemical forms, and Mercury and its inorganic and organic chemical forms were described in approximately 117,000 and 164,000 documents, respectively. United States was the country with the highest number of published documents in all the keywords analyzed. Chemistry, Medicine and Environmental Science were the subject categories with the highest number of documents. Researchers from the United States, China, Japan, Slovenia, and Brazil were in the ranking of the most productive authors. To our knowledge, this is the first bibliometric study on Selenium and Mercury and can be useful to identify potential research groups for scientific collaborations.

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“…Seemingly, there is an interaction between nitrogen-containing products of radical and ionic aimsa decomposition at [OH Ϫ ] у 0.2 : carbodiimide, urea and cyanamide. The formation of these compounds was observed in alkaline solutions of aimsa 30 and some of them may be formed from the nitrogen-containing radical, produced in reaction (5).…”

Section: ϫmentioning

confidence: 99%

Investigation of the redox interaction between iron(III) 5,10,15,20-tetrakis( p-sulfonatophenyl)porphyrinate and aminoiminomethanesulfinic acid in aqueous solution

Lepentsiotis¹,

Eldik²,

Stulov³

et al. 1998

J. Chem. Soc., Dalton Trans.

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Reduction of Organoselenium and Tellurium Halides and Oxides with Thiourea Dioxide

Cited by 34 publications

References 1 publication

A Possible Mechanism for Thiourea-Based Toxicities: Kinetics and Mechanism of Decomposition of Thiourea Dioxides in Alkaline Solutions

A Possible Mechanism for Thiourea-Based Toxicities: Kinetics and Mechanism of Decomposition of Thiourea Dioxides in Alkaline Solutions

The evolution of Selenium and Mercury research from 1700 to 2017 based on bibliometric analysis

Investigation of the redox interaction between iron(III) 5,10,15,20-tetrakis( p-sulfonatophenyl)porphyrinate and aminoiminomethanesulfinic acid in aqueous solution

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