Reduction of oxidative stress and ornithine decarboxylase expression in a human prostate cancer cell line PC-3 by a combined treatment with α-tocopherol and naringenin

Piera, Torricelli; Elia, Antonia Concetta; Magara, Gabriele; Feriotto, Giordana; Forni, C.; Borromeo, Ilaria; Martino, Angelo; Tabolacci, Claudio; Mischiati, Carlo; Beninati, Simone

doi:10.1007/s00726-020-02925-1

Cited by 6 publications

(6 citation statements)

References 52 publications

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“…It stopped the cell cycle and induced apoptosis in several human tumor cells [64,65], and also suppressed the invasiveness and metastatic potential of gastric cancer cells and hepatocellular carcinoma cells [66,67]. Naringenin had a pro-oxidant effect as reduced the glutathione reductase, glutathione S-transferase and glyoxalase activities in tumor cells, which in turn reduced the mechanisms of detoxification of hydrogen peroxide consenting the accumulation and the augment of lipid peroxidation with consequent cell membrane damage [68]. Interestingly, a recently concluded phase 1 clinical trial has highlighted the safety and pharmacokinetics of naringenin [69].…”

Section: Flavonoids and Oxidative Stressmentioning

confidence: 99%

“…Differentiation therapy aims to induce the differentiation of cancer cells; thus, reducing their proliferation [68]. Differentiation therapy compared to conventional chemotherapy has the advantage of being less toxic and, therefore, causing fewer side effects to the patient [98].…”

Section: Flavonoids and Cancer Cell Differentiationmentioning

confidence: 99%

“…Combined treatments with multiple molecules can improve the overall clinical efficacy of current anticancer drugs [68,106]. Due to multi-drug resistance and tumor recurrence, the development of new strategies to improve sensitivity to chemotherapy and minimize adverse side effects is still urgent.…”

Section: Flavonoids To Improve Sensitivity To Chemotherapymentioning

confidence: 99%

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Flavonoids: A Myth or a Reality for Cancer Therapy?

et al. 2021

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Nutraceuticals are biologically active molecules present in foods; they can have beneficial effects on health, but they are not available in large enough quantities to perform this function. Plant metabolites, such as polyphenols, are widely diffused in the plant kingdom, where they play fundamental roles in plant development and interactions with the environment. Among these, flavonoids are of particular interest as they have significant effects on human health. In vitro and/or in vivo studies described flavonoids as essential nutrients for preventing several diseases. They display broad and promising bioactivities to fight cancer, inflammation, bacterial infections, as well as to reduce the severity of neurodegenerative and cardiovascular diseases or diabetes. Therefore, it is not surprising that interest in flavonoids has sharply increased in recent years. More than 23,000 scientific publications on flavonoids have described the potential anticancer activity of these natural molecules in the last decade. Studies, in vitro and in vivo, show that flavonoids exhibit anticancer properties, and many epidemiological studies confirm that dietary intake of flavonoids leads to a reduced risk of cancer. This review provides a glimpse of the mechanisms of action of flavonoids on cancer cells.

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Section: Flavonoids and Oxidative Stressmentioning

confidence: 99%

Section: Flavonoids and Cancer Cell Differentiationmentioning

confidence: 99%

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Flavonoids: A Myth or a Reality for Cancer Therapy?

et al. 2021

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“…It also reduced gastric cancer and hepatocellular carcinoma cell invasiveness and metastasis [83,84]. The pro-oxidant action of naringenin was due to the suppression of glutathione-reductase, glutathione-S-transferase, and glyoxalase activities in tumor cells [85]. This, in turn, allowed for the buildup and the augmentation of lipid peroxidation, leading to cell membrane damage.…”

Section: Relationship Between Flavonoids and Oxidative Stressmentioning

confidence: 98%

Current Understanding of Flavonoids in Cancer Therapy and Prevention

et al. 2023

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Cancer is a major cause of death worldwide, with multiple pathophysiological manifestations. In particular, genetic abnormalities, inflammation, bad eating habits, radiation exposure, work stress, and toxin consumption have been linked to cancer disease development and progression. Recently, natural bioactive chemicals known as polyphenols found in plants were shown to have anticancer capabilities, destroying altered or malignant cells without harming normal cells. Flavonoids have demonstrated antioxidant, antiviral, anticancer, and anti-inflammatory effects. Flavonoid type, bioavailability, and possible method of action determine these biological actions. These low-cost pharmaceutical components have significant biological activities and are beneficial for several chronic disorders, including cancer. Recent research has focused primarily on isolating, synthesizing, and studying the effects of flavonoids on human health. Here we have attempted to summarize our current knowledge of flavonoids, focusing on their mode of action to better understand their effects on cancer.

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“…An oxidative burst may be important for the destruction of viral and pathogens components but may also exacerbate mortality in aquatic organisms [ 35 ]. The levels of antioxidant and detoxifying molecules, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR), glyoxalase I and II (GI and GII), lactate dehydrogenase (LDH) and total glutathione (GSH + 2GSSG), can be modulated as defense against oxidative pressure [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. While SOD, CAT and GPx can dismutate the harmful ROS superoxide anion (O 2 − ) and hydrogen peroxide (H 2 O 2 ) in water, GST and glyoxalases metabolize xenobiotics and potentially toxic compounds.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Antioxidant Defense in Farmed Rainbow Trout (Oncorhynchus mykiss) Fed with a Diet Supplemented by the Waste Derived from the Supercritical Fluid Extraction of Basil (Ocimum basilicum)

et al. 2022

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Phytotherapy is based on the use of plants to prevent or treat human and animal diseases. Recently, the use of essential oils and polyphenol-enriched extracts is also rapidly increasing in the aquaculture sector as a means of greater industrial and environmental sustainability. Previous studies assessed the antibacterial and antiparasitic effects of these bioactive compounds on fish. However, studies on the modulation of oxidative stress biomarkers are still scant to date. Thus, in this study, the modulation of antioxidant defense against oxidative stress exerted by fish diets supplemented with a basil supercritical extract (F1-BEO) was assessed in rainbow trout Oncorhynchus mykiss. The F1-BEO extracted with supercritical fluid extraction was added to the commercial feed flour (0.5, 1, 2, 3% w/w) and mixed with fish oil to obtain a suitable compound for pellet preparation. Fish were fed for 30 days. The levels of stress biomarkers such as superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glyoxalase I, glyoxalase II, lactate dehydrogenase, glutathione and malondialdehyde showed a boost in the antioxidant pathway in fish fed with a 0.5% F1-BEO-supplemented diet. Higher F1-BEO supplementation led to a failure of activity of several enzymes and the depletion of glutathione levels. Malondialdehyde concentration suggests a sufficient oxidative stress defense against lipid peroxidation in all experimental groups, except for a 3% F1-BEO-supplemented diet (liver 168.87 ± 38.79 nmol/mg prot; kidney 146.86 ± 23.28 nmol/mg prot), compared to control (liver 127.76 ± 18.15 nmol/mg prot; kidney 98.68 ± 15.65 nmol/mg prot). Our results suggest supplementing F1-BEO in fish diets up to 0.5% to avoid potential oxidative pressure in farmed trout.

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Reduction of oxidative stress and ornithine decarboxylase expression in a human prostate cancer cell line PC-3 by a combined treatment with α-tocopherol and naringenin

Cited by 6 publications

References 52 publications

Flavonoids: A Myth or a Reality for Cancer Therapy?

Flavonoids: A Myth or a Reality for Cancer Therapy?

Current Understanding of Flavonoids in Cancer Therapy and Prevention

Modulation of Antioxidant Defense in Farmed Rainbow Trout (Oncorhynchus mykiss) Fed with a Diet Supplemented by the Waste Derived from the Supercritical Fluid Extraction of Basil (Ocimum basilicum)

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