2022
DOI: 10.1016/j.biopha.2021.112525
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Reduction of oxidative stress blunts the NLRP3 inflammatory cascade in LPS stimulated human gingival fibroblasts and oral mucosal epithelial cells

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Cited by 18 publications
(8 citation statements)
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“…Notably, several studies have shown the inhibition of NLRP3 inflammasome activation and protection against LPS-induced damage in human gingival fibroblasts using agents such as the Vitamin D analog, Eldecalcitol (52), and the antioxidants, Flavocoxid (9) and Fisetin (53). Although those studies were similar in design, the current study provided a number of novel observations compared with the aforementioned studies.…”
Section: Discussionmentioning
confidence: 77%
See 1 more Smart Citation
“…Notably, several studies have shown the inhibition of NLRP3 inflammasome activation and protection against LPS-induced damage in human gingival fibroblasts using agents such as the Vitamin D analog, Eldecalcitol (52), and the antioxidants, Flavocoxid (9) and Fisetin (53). Although those studies were similar in design, the current study provided a number of novel observations compared with the aforementioned studies.…”
Section: Discussionmentioning
confidence: 77%
“…It has been reported that Porphyromonas gingivalis infection stimulates activation of the NLRP3 inflammasome and the production of IL-1β (8). Similarly, bacterial endotoxin lipopolysaccharide (LPS) has been shown to activate the NLRP3 inflammasome and stimulate the production of IL-1β in oral epithelial cells (9,10). Gingival epithelial cells (GECs) have been reported to have an important role as a component of innate host response to periodontal bacteria and significantly contribute to gingival health (11).…”
Section: Introductionmentioning
confidence: 99%
“…Following three washes with TBS-0.15% Tween buffer, membranes were analyzed by the enhanced chemiluminescence system (LumiGlo reserve; Seracare, Milford, MA, USA) and the protein signal were quantified by a scanning densitometry system (C-DiGit, Li-cor, Lincoln, NE, USA). Results were expressed as relative integrated intensity using β-actin (Cell Signaling, Danvers, MA, USA) as a control for the equal loading of samples [ 46 , 47 , 48 , 49 , 50 ].…”
Section: Methodsmentioning
confidence: 99%
“…Taking into account the pro-oxidant mechanisms involved in the pathogenesis of oral mucositis, it seems clear that new research models of oxidative stress-induced mucositis, in which the new therapeutic interventions can be tested in oral mucosal cells, are needed. Several attempts to characterize oxidative stress using in vitro models of oral mucosal inflammation have been conducted recently [ 22 , 30 , 31 , 32 , 33 , 34 ]. In particular, it is essential to establish a dose–response curve of the effects of ROS in oral keratinocytes.…”
Section: Introductionmentioning
confidence: 99%